Probabilistic fine-mapping of transcriptome-wide association studies von Mancuso, Nicholas, Freund, Malika K., Johnson, Ruth, Shi, Huwenbo, Kichaev, Gleb, Gusev, Alexander, Pasaniuc, Bogdan

Volltext

Leveraging Polygenic Functional Enrichment to Improve GWAS Power von Kichaev, Gleb, Bhatia, Gaurav, Loh, Po-Ru, Gazal, Steven, Burch, Kathryn, Freund, Malika K., Schoech, Armin, Pasaniuc, Bogdan, Price, Alkes L.

Volltext

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms von Walker, Rebecca L., Ramaswami, Gokul, Hartl, Christopher, Mancuso, Nicholas, Gandal, Michael J., de la Torre-Ubieta, Luis, Pasaniuc, Bogdan, Stein, Jason L., Geschwind, Daniel H.

Volltext

Colocalization of GWAS and eQTL Signals Detects Target Genes von Hormozdiari, Farhad, van de Bunt, Martijn, Segrè, Ayellet V., Li, Xiao, Joo, Jong Wha J., Bilow, Michael, Sul, Jae Hoon, Sankararaman, Sriram, Pasaniuc, Bogdan, Eskin, Eleazar

Volltext

Efficient variance components analysis across millions of genomes von Pazokitoroudi, Ali, Wu, Yue, Burch, Kathryn S., Hou, Kangcheng, Zhou, Aaron, Pasaniuc, Bogdan, Sankararaman, Sriram

Volltext

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification von Ding, Yi, Hou, Kangcheng, Burch, Kathryn S., Lapinska, Sandra, Privé, Florian, Vilhjálmsson, Bjarni, Sankararaman, Sriram, Pasaniuc, Bogdan

Volltext

A Bayesian framework for multiple trait colocalization from summary association statistics von Giambartolomei, Claudia, Zhenli Liu, Jimmy, Zhang, Wen, Hauberg, Mads, Shi, Huwenbo, Boocock, James, Pickrell, Joe, Jaffe, Andrew E, Pasaniuc, Bogdan, Roussos, Panos

Volltext

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization von Pathak, Gita A., Singh, Kritika, Miller-Fleming, Tyne W., Wendt, Frank R., Ehsan, Nava, Hou, Kangcheng, Johnson, Ruth, Lu, Zeyun, Gopalan, Shyamalika, Yengo, Loic, Mohammadi, Pejman, Pasaniuc, Bogdan, Polimanti, Renato, Davis, Lea K., Mancuso, Nicholas

Volltext

Optimized design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis von Mandric, Igor, Schwarz, Tommer, Majumdar, Arunabha, Hou, Kangcheng, Briscoe, Leah, Perez, Richard, Subramaniam, Meena, Hafemeister, Christoph, Satija, Rahul, Ye, Chun Jimmie, Pasaniuc, Bogdan, Halperin, Eran

Volltext

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies von Feng, Helian, Mancuso, Nicholas, Gusev, Alexander, Majumdar, Arunabha, Major, Megan, Pasaniuc, Bogdan, Kraft, Peter

Volltext

Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits von Zaitlen, Noah, Kraft, Peter, Patterson, Nick, Pasaniuc, Bogdan, Bhatia, Gaurav, Pollack, Samuela, Price, Alkes L

Volltext

Integrating functional data to prioritize causal variants in statistical fine-mapping studies von Kichaev, Gleb, Yang, Wen-Yun, Lindstrom, Sara, Hormozdiari, Farhad, Eskin, Eleazar, Price, Alkes L, Kraft, Peter, Pasaniuc, Bogdan

Volltext

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights von Gusev, Alexander, Mancuso, Nicholas, Won, Hyejung, Kousi, Maria, Finucane, Hilary K., Reshef, Yakir, Song, Lingyun, Safi, Alexias, McCarroll, Steven, Neale, Benjamin M., Ophoff, Roel A., O’Donovan, Michael C., Crawford, Gregory E., Geschwind, Daniel H., Katsanis, Nicholas, Sullivan, Patrick F., Pasaniuc, Bogdan, Price, Alkes L.

Volltext

Improved methods for multi-trait fine mapping of pleiotropic risk loci von Kichaev, Gleb, Roytman, Megan, Johnson, Ruth, Eskin, Eleazar, Lindström, Sara, Kraft, Peter, Pasaniuc, Bogdan

Volltext

Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma von Choi, Jiyeon, Zhang, Tongwu, Vu, Andrew, Ablain, Julien, Makowski, Matthew M., Colli, Leandro M., Xu, Mai, Hennessey, Rebecca C., Yin, Jinhu, Rothschild, Harriet, Gräwe, Cathrin, Kovacs, Michael A., Funderburk, Karen M., Brossard, Myriam, Taylor, John, Pasaniuc, Bogdan, Chari, Raj, Chanock, Stephen J., Hoggart, Clive J., Demenais, Florence, Barrett, Jennifer H., Law, Matthew H., Iles, Mark M., Yu, Kai, Vermeulen, Michiel, Zon, Leonard I., Brown, Kevin M.

Volltext

Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD von Gandal, Michael J., Haney, Jillian R., Wamsley, Brie, Yap, Chloe X., Parhami, Sepideh, Emani, Prashant S., Chang, Nathan, Chen, George T., Hoftman, Gil D., de Alba, Diego, Ramaswami, Gokul, Hartl, Christopher L., Bhattacharya, Arjun, Luo, Chongyuan, Jin, Ting, Wang, Daifeng, Kawaguchi, Riki, Quintero, Diana, Ou, Jing, Wu, Ye Emily, Parikshak, Neelroop N., Swarup, Vivek, Belgard, T. Grant, Gerstein, Mark, Pasaniuc, Bogdan, Geschwind, Daniel H.

Volltext

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data von Shi, Huwenbo, Kichaev, Gleb, Pasaniuc, Bogdan

Volltext

Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data von Shi, Huwenbo, Burch, Kathryn S., Johnson, Ruth, Freund, Malika K., Kichaev, Gleb, Mancuso, Nicholas, Manuel, Astrid M., Dong, Natalie, Pasaniuc, Bogdan

Volltext

Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits von Johnson, Ruth, Burch, Kathryn S, Hou, Kangcheng, Paciuc, Mario, Pasaniuc, Bogdan, Sankararaman, Sriram

Volltext

A summary-statistics-based approach to examine the role of serotonin transporter promoter tandem repeat polymorphism in psychiatric phenotypes von Majumdar, Arunabha, Patel, Preksha, Pasaniuc, Bogdan, Ophoff, Roel A

Volltext