A Protocol for Improved Precision and Increased Confidence in Nanoparticle Tracking Analysis Concentration Measurements between 50 and 120 nm in Biological Fluids von Parsons, Martin E M, McParland, Damien, Szklanna, Paulina B, Guang, Matthew Ho Zhi, O'Connell, Karen, O'Connor, Hugh D, McGuigan, Christopher, Ní Áinle, Fionnuala, McCann, Amanda, Maguire, Patricia B

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Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults von Parsons, Martin E. M., Szklanna, Paulina B., Guerrero, Jose A., Wynne, Kieran, Dervin, Feidhlim, O'Connell, Karen, Allen, Seamus, Egan, Karl, Bennett, Cavan, McGuigan, Christopher, Gheveart, Cedric, Ní Áinle, Fionnuala, Maguire, Patricia B.

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Front Cover: Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults von Parsons, Martin E. M., Szklanna, Paulina B., Guerrero, Jose A., Wynne, Kieran, Dervin, Feidhlim, O'Connell, Karen, Allen, Seamus, Egan, Karl, Bennett, Cavan, McGuigan, Christopher, Gheveart, Cedric, Ní Áinle, Fionnuala, Maguire, Patricia B.

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Thrombin generation correlates with disease duration in multiple sclerosis (MS): Novel insights into the MS-associated prothrombotic state von Parsons, Martin EM, O’Connell, Karen, Allen, Seamus, Egan, Karl, Szklanna, Paulina B, McGuigan, Christopher, Ní Áinle, Fionnuala, Maguire, Patricia B

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Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke von Ma, Henry, Campbell, Bruce C.V, Parsons, Mark W, Churilov, Leonid, Levi, Christopher R, Hsu, Chung, Kleinig, Timothy J, Wijeratne, Tissa, Curtze, Sami, Dewey, Helen M, Miteff, Ferdinand, Tsai, Chon-Haw, Lee, Jiunn-Tay, Phan, Thanh G, Mahant, Neil, Sun, Mu-Chien, Krause, Martin, Sturm, Jonathan, Grimley, Rohan, Chen, Chih-Hung, Hu, Chaur-Jong, Wong, Andrew A, Field, Deborah, Sun, Yu, Barber, P. Alan, Sabet, Arman, Jannes, Jim, Jeng, Jiann-Shing, Clissold, Benjamin, Markus, Romesh, Lin, Ching-Huang, Lien, Li-Ming, Bladin, Christopher F, Christensen, Søren, Yassi, Nawaf, Sharma, Gagan, Bivard, Andrew, Desmond, Patricia M, Yan, Bernard, Mitchell, Peter J, Thijs, Vincent, Carey, Leeanne, Meretoja, Atte, Davis, Stephen M, Donnan, Geoffrey A

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Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke von Anderson, Craig S, Robinson, Thompson, Lindley, Richard I, Arima, Hisatomi, Lavados, Pablo M, Lee, Tsong-Hai, Broderick, Joseph P, Chen, Xiaoying, Chen, Guofang, Sharma, Vijay K, Kim, Jong S, Thang, Nguyen H, Cao, Yongjun, Parsons, Mark W, Levi, Christopher, Huang, Yining, Olavarría, Verónica V, Demchuk, Andrew M, Bath, Philip M, Donnan, Geoffrey A, Martins, Sheila, Pontes-Neto, Octavio M, Silva, Federico, Ricci, Stefano, Roffe, Christine, Pandian, Jeyaraj, Billot, Laurent, Woodward, Mark, Li, Qiang, Wang, Xia, Wang, Jiguang, Chalmers, John

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Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data von Campbell, Bruce C V, Leys, Didier, Molina, Carlos, Curtze, Sami, De Silva, Deidre A, Bladin, Christopher F, Pfaff, Johannes A R, Sharma, Gagan, Desmond, Patricia M, Toni, Danilo, Thijs, Vincent, Churilov, Leonid, Yan, Bernard, Mitchell, Peter J., Sharma, Gagan, Desmond, Patricia M., Oxley, Thomas, Rodrigues, Edrich, Williams, Cameron, Ng, Jo-Lyn, Tu, Hans T-H., McCoy, Rachael, Patel, S., Harvey, J., Cheong, E., Waters, Michael, Wijeratne, Tissa, Bladin, Christopher F., Loh, Poh Sien, Coote, Skye, Moore, A., Ross, Z., Miteff, Ferdinand, Ang, Timothy, Garcia-Esperon, Carlos, Krause, Martin, Day, Susan, Young, Dennis, Wong, Andrew A., Muller, Claire, Vallat, W., Bailey, Peter, Sabet, Arman, Mishra, Sachin, Tan, Meng, George, K., Tatlisumak, Turgut, Sibolt, G., Tiainen, M., Koivu, M., Eirola, S., Lin, C.M., Ho, S.C., Tsai, C.H., Lu, C.H., Kung, W.L., Jiang, S.K., Kuan, C.W., Tsai, H.T., Lu, C.J., Ysai, C.L., Jeng, J.S., Tang, S.C., Chung, T.C., Hu, C.J., Chan, L., Yeh, H.L., Peng, G.S., Cheng, C.A., Hsu, C.H., Sung, Y.F., Blacker, David, Chen, C-I., Cowley, Elise, Kolbe, John, Macdonnell, Richard, Attia, John, Cadilhac, Dominique, Anderson, Craig, Howells, David, Barber, A., Bendszus, Martin, Hacke, Werner, Ringleb, Peter, Toni, Danilo, Ehrenkrona, Christina, Cove, Lynda, Niederkorn, Kurt, Mikulik, Robert, Mas, Jean-Louis, Berrouschot, Jörg, Sobesky, Jan, Kessler, Christof, Poli, Sven, Althaus-Knaurer, Katharina, Rodriguez, Alain L., Muir, Keith, Fink, John N., McNeil, John, Williams, M.

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A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury von Stapleton, Renee D, Martin, Thomas R, Weiss, Noel S, Crowley, Joseph J, Gundel, Stephanie J, Nathens, Avery B, Akhtar, Saadia R, Ruzinski, John T, Caldwell, Ellen, Curtis, J. Randall, Heyland, Daren K, Watkins, Timothy R, Parsons, Polly E, Martin, Julie M, Wurfel, Mark M, Hallstrand, Teal S, Sims, Kathryn A, Neff, Margaret J

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The effect of foetal bovine serum supplementation upon the lactate dehydrogenase cytotoxicity assay: Important considerations for in vitro toxicity analysis von Thomas, Martin G., Marwood, Roxanne M., Parsons, Anna E., Parsons, Richard B.

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The evolutionary status of Cataclysmic Variables: eclipse modelling of 15 systems von McAllister, M, Littlefair, S P, Parsons, S G, Dhillon, V S, Marsh, T R, Gänsicke, B T, Breedt, E, Copperwheat, C, Green, M J, Knigge, C, Sahman, D I, Dyer, Martin J, Kerry, P, Ashley, R P, Irawati, P, Rattanasoon, S

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Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations von Sidders, Ashelyn E, Kedziora, Katarzyna M, Arts, Melina, Daniel, Jan-Martin, de Benedetti, Stefania, Beam, Jenna E, Bui, Duyen T, Parsons, Joshua B, Schneider, Tanja, Rowe, Sarah E, Conlon, Brian P

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A continental-scale tool for acoustic identification of European bats von Walters, Charlotte L., Freeman, Robin, Collen, Alanna, Dietz, Christian, Fenton, M. Brock, Jones, Gareth, Obrist, Martin K., Puechmaille, Sébastien J., Sattler, Thomas, Siemers, Björn M., Parsons, Stuart, Jones, Kate E.

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Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection von Campbell, Bruce C.V, Mitchell, Peter J, Kleinig, Timothy J, Dewey, Helen M, Churilov, Leonid, Yassi, Nawaf, Yan, Bernard, Dowling, Richard J, Parsons, Mark W, Oxley, Thomas J, Wu, Teddy Y, Brooks, Mark, Simpson, Marion A, Miteff, Ferdinand, Levi, Christopher R, Krause, Martin, Harrington, Timothy J, Faulder, Kenneth C, Steinfort, Brendan S, Priglinger, Miriam, Ang, Timothy, Scroop, Rebecca, Barber, P. Alan, McGuinness, Ben, Wijeratne, Tissa, Phan, Thanh G, Chong, Winston, Chandra, Ronil V, Bladin, Christopher F, Badve, Monica, Rice, Henry, de Villiers, Laetitia, Ma, Henry, Desmond, Patricia M, Donnan, Geoffrey A, Davis, Stephen M

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ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis von Towler, Paul, Staker, Bart, Prasad, Sridhar G., Menon, Saurabh, Tang, Jin, Parsons, Thomas, Ryan, Dominic, Fisher, Martin, Williams, David, Dales, Natalie A., Patane, Michael A., Pantoliano, Michael W.

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Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability von Martín-Villar, E, Borda-d'Agua, B, Carrasco-Ramirez, P, Renart, J, Parsons, M, Quintanilla, M, Jones, G E

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Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms von Lubitz, Steven A, Parsons, Owen E, Anderson, Christopher D, Benjamin, Emelia J, Malik, Rainer, Weng, Lu-Chen, Dichgans, Martin, Sudlow, Cathie L, Rothwell, Peter M, Rosand, Jonathan, Ellinor, Patrick T, Markus, Hugh S, Traylor, Matthew

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Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expression von Li Mow Chee, Frederic, Beernaert, Bruno, Griffith, Billie G. C., Loftus, Alexander E. P., Kumar, Yatendra, Wills, Jimi C., Lee, Martin, Valli, Jessica, Wheeler, Ann P., Armstrong, J. Douglas, Parsons, Maddy, Leigh, Irene M., Proby, Charlotte M., von Kriegsheim, Alex, Bickmore, Wendy A., Frame, Margaret C., Byron, Adam

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Does a functional activity programme improve function, quality of life, and falls for residents in long term care? Cluster randomised controlled trial von Kerse, Ngaire, Peri, Kathy, Robinson, Elizabeth, Wilkinson, Tim, Randow, Martin von, Kiata, Liz, Parsons, John, Latham, Nancy, Parsons, Matthew, Willingale, Jane, Brown, Paul, Arroll, Bruce

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Thrombectomy versus Medical Management in Mild Strokes due to Large Vessel Occlusion: Exploratory Analysis from the EXTEND‐IA Trials and a Pooled International Cohort von Sarraj, Amrou, Albers, Gregory W., Blasco, Jordi, Arenillas, Juan F., Ribo, Marc, Hassan, Ameer E., Ossa, Natalia Pérez, Wu, Teddy Yuan‐Hao, Cardona Portela, Pere, Abraham, Michael G., Chen, Michael, Maali, Laith, Kleinig, Timothy J., Cordato, Dennis, Wallace, Adam Nathan, Schaafsma, Joanna D., Sangha, Navdeep, Gibson, Daniel P., Blackburn, Spiros L., De Lera Alfonso, Mercedes, Pujara, Deep, Shaker, Faris, McCullough‐Hicks, Margy E., Moreno Negrete, Javier Luis, Renu, Arturo, Beharry, James, Cappelen‐Smith, Cecilia, Rodríguez‐Esparragoza, Luis, Olivé‐Gadea, Marta, Requena, Manuel, Almaghrabi, Tareq, Mendes Pereira, Vitor, Sitton, Clark, Martin‐Schild, Sheryl, Song, Sarah, Ma, Henry, Churilov, Leonid, Mitchell, Peter J., Parsons, Mark W., Furlan, Anthony, Grotta, James C., Donnan, Geoffrey A., Davis, Stephen M., Campbell, Bruce C. V.

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Genetic correlates of phenotypic heterogeneity in autism von Warrier, Varun, Zhang, Xinhe, Reed, Patrick, Havdahl, Alexandra, Moore, Tyler M., Cliquet, Freddy, Leblond, Claire S., Rolland, Thomas, Rosengren, Anders, Rowitch, David H., Hurles, Matthew E., Geschwind, Daniel H., Børglum, Anders D., Robinson, Elise B., Grove, Jakob, Martin, Hilary C., Bourgeron, Thomas, Baron-Cohen, Simon

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