PTEN Loss Confers BRAF Inhibitor Resistance to Melanoma Cells through the Suppression of BIM Expression von PARAISO, Kim H. T, YUN XIANG, RIBAS, Antoni, DALLA PALMA, Maurizia, NATHANSON, Katherine L, KOOMEN, John M, MESSINA, Jane L, SMALLEY, Keiran S. M, REBECCA, Vito W, ABEL, Ethan V, CHEN, Y. Ann, MUNKO, A. Cecilia, WOOD, Elizabeth, FEDORENKO, Inna V, SONDAK, Vernon K, ANDERSON, Alexander R. A

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Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma von Fedorenko, Inna V., Paraiso, Kim H.T., Smalley, Keiran S.M.

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Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy von Paraiso, K H T, Fedorenko, I V, Cantini, L P, Munko, A C, Hall, M, Sondak, V K, Messina, J L, Flaherty, K T, Smalley, K S M

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The HSP90 Inhibitor XL888 Overcomes BRAF Inhibitor Resistance Mediated through Diverse Mechanisms von PARAISO, Kim H. T, HAARBERG, H. Eirik, JOHN, Jobin K, SARNAIK, Amod A, KOOMEN, John M, SMALLEY, Keiran S. M, WOOD, Elizabeth, REBECCA, Vito W, CHEN, Y. Ann, YUN XIANG, RIBAS, Antoni, LO, Roger S, WEBER, Jeffrey S, SONDAK, Vernon K

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SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells von Brooks, Robert, Fuhler, Gwenny M, Iyer, Sonia, Smith, Michelle J, Park, Mi-Young, Paraiso, Kim H. T, Engelman, Robert W, Kerr, William G

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Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells von Beck, Daniela, Niessner, Heike, Smalley, Keiran S M, Flaherty, Keith, Paraiso, Kim H T, Busch, Christian, Sinnberg, Tobias, Vasseur, Sophie, Iovanna, Juan Lucio, Drießen, Stefan, Stork, Björn, Wesselborg, Sebastian, Schaller, Martin, Biedermann, Tilo, Bauer, Jürgen, Lasithiotakis, Konstantinos, Weide, Benjamin, Eberle, Jürgen, Schittek, Birgit, Schadendorf, Dirk, Garbe, Claus, Kulms, Dagmar, Meier, Friedegund

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Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma von Rebecca, Vito W., Alicea, Gretchen M., Paraiso, Kim H. T., Lawrence, Harshani, Gibney, Geoffrey T., Smalley, Keiran S. M.

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Evaluating Melanoma Drug Response and Therapeutic Escape with Quantitative Proteomics von Rebecca, Vito W., Wood, Elizabeth, Fedorenko, Inna V., Paraiso, Kim H.T., Haarberg, H. Eirik, Chen, Yi, Xiang, Yun, Sarnaik, Amod, Gibney, Geoffrey T., Sondak, Vernon K., Koomen, John M., Smalley, Keiran S.M.

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Induced SHIP Deficiency Expands Myeloid Regulatory Cells and Abrogates Graft-versus-Host Disease von Paraiso, Kim H. T, Ghansah, Tomar, Costello, Amy, Engelman, Robert W, Kerr, William G

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Fibroblast-mediated drug resistance in cancer von Paraiso, Kim H.T., Smalley, Keiran S.M.

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GSK3β Inhibition Blocks Melanoma Cell/Host Interactions by Downregulating N-Cadherin Expression and Decreasing FAK Phosphorylation von John, Jobin K., Paraiso, Kim H.T., Rebecca, Vito W., Cantini, Liliana P., Abel, Ethan V., Pagano, Nicholas, Meggers, Eric, Mathew, Rahel, Krepler, Clemens, Izumi, Victoria, Fang, Bin, Koomen, John M., Messina, Jane L., Herlyn, Meenhard, Smalley, Keiran S.M.

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Inappropriate Recruitment and Activity by the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP1) Is Responsible for Receptor Dominance in the SHIP-Deficient NK Cell von Wahle, Joseph A, Paraiso, Kim H. T, Kendig, Robert D, Lawrence, Harshani R, Chen, Liwei, Wu, Jerry, Kerr, William G

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Expansion of Myeloid Suppressor Cells in SHIP-Deficient Mice Represses Allogeneic T Cell Responses von Ghansah, Tomar, Paraiso, Kim H. T, Highfill, Steven, Desponts, Caroline, May, Sarah, McIntosh, Joseph K, Wang, Jia-Wang, Ninos, John, Brayer, Jason, Cheng, Fengdong, Sotomayor, Eduardo, Kerr, William G

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Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis von Nogueira, C, Kim, K-H, Sung, H, Paraiso, K H T, Dannenberg, J-H, Bosenberg, M, Chin, L, Kim, M

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Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP von Collazo, Michelle M., Paraiso, Kim H. T., Park, Mi‐Young, Hazen, Amy L., Kerr, William G.

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Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma models von Smyth, Tomoko, Paraiso, Kim H T, Hearn, Keisha, Rodriguez-Lopez, Ana M, Munck, Joanne M, Haarberg, H Eirik, Sondak, Vernon K, Thompson, Neil T, Azab, Mohammad, Lyons, John F, Smalley, Keiran S M, Wallis, Nicola G

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SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation von Desponts, Caroline, Hazen, Amy L., Paraiso, Kim H.T., Kerr, William G.

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Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges von Song, Kai, Minami, Jenna K, Huang, Arthur, Dehkordi, Siavash R, Lomeli, Shirley H, Luebeck, Jens, Goodman, Mark H, Moriceau, Gatien, Krijgsman, Oscar, Dharanipragada, Prashanthi, Ridgley, Trevor, Crosson, William P, Salazar, Jesus, Pazol, Eli, Karin, Gabriel, Jayaraman, Rachana, Balanis, Nikolas G, Alhani, Salwan, Sheu, Kyle, Ten Hoeve, Johanna, Palermo, Amelia, Motika, Stephen E, Senaratne, T Niroshi, Paraiso, Kim H, Hergenrother, Paul J, Rao, P Nagesh, Multani, Asha S, Peeper, Daniel S, Bafna, Vineet, Lo, Roger S, Graeber, Thomas G

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Ligand-independent EPHA2 signaling drives the adoption of a targeted therapy-mediated metastatic melanoma phenotype von Paraiso, Kim H T, Das Thakur, Meghna, Fang, Bin, Koomen, John M, Fedorenko, Inna V, John, Jobin K, Tsao, Hensin, Flaherty, Keith T, Sondak, Vernon K, Messina, Jane L, Pasquale, Elena B, Villagra, Alejandro, Rao, Uma N, Kirkwood, John M, Meier, Friedegund, Sloot, Sarah, Gibney, Geoffrey T, Stuart, Darrin, Tawbi, Hussein, Smalley, Keiran S M

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Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies von Kudchadkar, Ragini, Paraiso, Kim H T, Smalley, Keiran S M

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