Development and Synthesis of DNA-Encoded Benzimidazole Library von Ding, Yun, Chai, Jing, Centrella, Paolo A, Gondo, Chenaimwoyo, DeLorey, Jennifer L, Clark, Matthew A

Volltext

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library von Cuozzo, John W., Centrella, Paolo A., Gikunju, Diana, Habeshian, Sevan, Hupp, Christopher D., Keefe, Anthony D., Sigel, Eric A., Soutter, Holly H., Thomson, Heather A., Zhang, Ying, Clark, Matthew A.

Volltext

Design, synthesis and selection of DNA-encoded small-molecule libraries von Clark, Matthew A, Acharya, Raksha A, Arico-Muendel, Christopher C, Belyanskaya, Svetlana L, Benjamin, Dennis R, Carlson, Neil R, Centrella, Paolo A, Chiu, Cynthia H, Creaser, Steffen P, Cuozzo, John W, Davie, Christopher P, Ding, Yun, Franklin, G Joseph, Franzen, Kurt D, Gefter, Malcolm L, Hale, Steven P, Hansen, Nils J V, Israel, David I, Jiang, Jinwei, Kavarana, Malcolm J, Kelley, Michael S, Kollmann, Christopher S, Li, Fan, Lind, Kenneth, Mataruse, Sibongile, Medeiros, Patricia F, Messer, Jeffrey A, Myers, Paul, O'Keefe, Heather, Oliff, Matthew C, Rise, Cecil E, Satz, Alexander L, Skinner, Steven R, Svendsen, Jennifer L, Tang, Lujia, van Vloten, Kurt, Wagner, Richard W, Yao, Gang, Zhao, Baoguang, Morgan, Barry A

Volltext

Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT) von Ding, Yun, Belyanskaya, Svetlana, DeLorey, Jennifer L., Messer, Jeffrey A., Joseph Franklin, G., Centrella, Paolo A., Morgan, Barry A., Clark, Matthew A., Skinner, Steven R., Dodson, Jason W., Li, Peng, Marino, Joseph P., Israel, David I.

Volltext

Design and Synthesis of Biaryl DNA-Encoded Libraries von Ding, Yun, Franklin, G. Joseph, DeLorey, Jennifer L, Centrella, Paolo A, Mataruse, Sibongile, Clark, Matthew A, Skinner, Steven R, Belyanskaya, Svetlana

Volltext

Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV‑2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronaviru... von Wang, Xu, Gotchev, Dimitar, Fan, Kristi Yi, Vega, Marvin M., Mani, Nagraj, McGovern-Gooch, Kayleigh, Cuconati, Andrea, Tercero, Breanna, Wang, Xiaohe, Carpino, Philip, Maskos, Klaus, Centrella, Paolo A., Schmitt, Andreas, Preuss, Franziska, Prasad, Archna, Chen, Chia-yi, Clark, Matthew A., Guilinger, John P., Johnstone, Shawn, von König, Konstanze, Keefe, Anthony D., Liu, Jenny, Turcotte, Stéphane, Zhang, Ying, Konz Makino, Debora L., Lam, Angela M., Cole, Andrew G., Sofia, Michael J.

Volltext

Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavir... von Wang, Xu, Gotchev, Dimitar, Fan, Kristi Yi, Vega, Marvin M, Mani, Nagraj, McGovern-Gooch, Kayleigh, Cuconati, Andrea, Tercero, Breanna, Wang, Xiaohe, Carpino, Philip, Maskos, Klaus, Centrella, Paolo A, Schmitt, Andreas, Preuss, Franziska, Prasad, Archna, Chen, Chia-Yi, Clark, Matthew A, Guilinger, John P, Johnstone, Shawn, von König, Konstanze, Keefe, Anthony D, Liu, Jenny, Turcotte, Stéphane, Zhang, Ying, Konz Makino, Debora L, Lam, Angela M, Cole, Andrew G, Sofia, Michael J

Volltext

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning von Ahmad, Shabbir, Xu, Jin, Feng, Jianwen A., Hutchinson, Ashley, Zeng, Hong, Ghiabi, Pegah, Dong, Aiping, Centrella, Paolo A., Clark, Matthew A., Guié, Marie-Aude, Guilinger, John P., Keefe, Anthony D., Zhang, Ying, Cerruti, Thomas, Cuozzo, John W., von Rechenberg, Moritz, Bolotokova, Albina, Li, Yanjun, Loppnau, Peter, Seitova, Alma, Li, Yen-Yen, Santhakumar, Vijayaratnam, Brown, Peter J., Ackloo, Suzanne, Halabelian, Levon

Volltext

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Re... von Wu, Zining, Graybill, Todd L, Zeng, Xin, Platchek, Michael, Zhang, Jean, Bodmer, Vera Q, Wisnoski, David D, Deng, Jianghe, Coppo, Frank T, Yao, Gang, Tamburino, Alex, Scavello, Genaro, Franklin, G. Joseph, Mataruse, Sibongile, Bedard, Katie L, Ding, Yun, Chai, Jing, Summerfield, Jennifer, Centrella, Paolo A, Messer, Jeffrey A, Pope, Andrew J, Israel, David I

Volltext

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry von Guilinger, John P., Archna, Archna, Augustin, Martin, Bergmann, Andreas, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Däther, Maike, Guié, Marie-Aude, Habeshian, Sevan, Kiefersauer, Reiner, Krapp, Stephan, Lammens, Alfred, Lercher, Lukas, Liu, Julie, Liu, Yanbin, Maskos, Klaus, Mrosek, Michael, Pflügler, Klaus, Siegert, Markus, Thomson, Heather A., Tian, Xia, Zhang, Ying, Konz Makino, Debora L., Keefe, Anthony D.

Volltext

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins von Ackloo, Suzanne, Li, Fengling, Szewczyk, Magda, Seitova, Almagul, Loppnau, Peter, Zeng, Hong, Xu, Jin, Ahmad, Shabbir, Arnautova, Yelena A, Baghaie, A J, Beldar, Serap, Bolotokova, Albina, Centrella, Paolo A, Chau, Irene, Clark, Matthew A, Cuozzo, John W, Dehghani-Tafti, Saba, Disch, Jeremy S, Dong, Aiping, Dumas, Antoine, Feng, Jianwen A, Ghiabi, Pegah, Gibson, Elisa, Gilmer, Justin, Goldman, Brian, Green, Stuart R, Guié, Marie-Aude, Guilinger, John P, Harms, Nathan, Herasymenko, Oleksandra, Houliston, Scott, Hutchinson, Ashley, Kearnes, Steven, Keefe, Anthony D, Kimani, Serah W, Kramer, Trevor, Kutera, Maria, Kwak, Haejin A, Lento, Cristina, Li, Yanjun, Liu, Jenny, Loup, Joachim, Machado, Raquel A C, Mulhern, Christopher J, Perveen, Sumera, Righetto, Germanna L, Riley, Patrick, Shrestha, Suman, Sigel, Eric A, Silva, Madhushika, Sintchak, Michael D, Slakman, Belinda L, Taylor, Rhys D, Thompson, James, Torng, Wen, Underkoffler, Carl, von Rechenberg, Moritz, Walsh, Ryan T, Watson, Ian, Wilson, Derek J, Wolf, Esther, Yadav, Manisha, Yazdi, Aliakbar K, Zhang, Junyi, Zhang, Ying, Santhakumar, Vijayaratnam, Edwards, Aled M, Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Brown, Peter J, Halabelian, Levon, Arrowsmith, Cheryl H

Volltext

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculos... von Encinas, Lourdes, O’Keefe, Heather, Neu, Margarete, Remuiñán, Modesto J, Patel, Amish M, Guardia, Ana, Davie, Christopher P, Pérez-Macías, Natalia, Yang, Hongfang, Convery, Maire A, Messer, Jeff A, Pérez-Herrán, Esther, Centrella, Paolo A, Álvarez-Gómez, Daniel, Clark, Matthew A, Huss, Sophie, O’Donovan, Gary K, Ortega-Muro, Fátima, McDowell, William, Castañeda, Pablo, Arico-Muendel, Christopher C, Pajk, Stane, Rullás, Joaquín, Angulo-Barturen, Iñigo, Álvarez-Ruíz, Emilio, Mendoza-Losana, Alfonso, Ballell Pages, Lluís, Castro-Pichel, Julia, Evindar, Ghotas

Volltext

Development of Potent Mcl‑1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen von Hekking, Koen F. W., Maroto, Sergio, van Kekem, Kees, Haasjes, Frank S., Slootweg, Jack C., Oude Alink, Patrick G. B., Dirks, Ron, Sardana, Malvika, Bolster, Marjon G., Kuijpers, Brian, Smith, Dennis, Doodeman, Robin, Scheepstra, Marcel, Zech, Birgit, Mulvihill, Mark, Renzetti, Louis M., Babiss, Lee, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Guié, Marie-Aude, Sigel, Eric, Habeshian, Sevan, Hupp, Christopher D., Liu, Julie, Thomson, Heather A., Zhang, Ying, Keefe, Anthony D., Müller, Gerhard, Gremmen, Stijn

Volltext

Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa von Ryan, M. Dominic, Parkes, Alastair L, Corbett, David, Dickie, Anthony P, Southey, Michelle, Andersen, Ole A, Stein, Daniel B, Barbeau, Olivier R, Sanzone, Angelo, Thommes, Pia, Barker, John, Cain, Ricky, Compper, Christel, Dejob, Magali, Dorali, Alain, Etheridge, Donnya, Evans, Sian, Faulkner, Adele, Gadouleau, Elise, Gorman, Timothy, Haase, Denes, Holbrow-Wilshaw, Maisie, Krulle, Thomas, Li, Xianfu, Lumley, Christopher, Mertins, Barbara, Napier, Spencer, Odedra, Rajesh, Papadopoulos, Kostas, Roumpelakis, Vasileios, Spear, Kate, Trimby, Emily, Williams, Jennifer, Zahn, Michael, Keefe, Anthony D, Zhang, Ying, Soutter, Holly T, Centrella, Paolo A, Clark, Matthew A, Cuozzo, John W, Dumelin, Christoph E, Deng, Boer, Hunt, Avery, Sigel, Eric A, Troast, Dawn M, DeJonge, Boudewijn L. M

Volltext

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action von Fernández-Montalván, Amaury E, Berger, Markus, Kuropka, Benno, Koo, Seong Joo, Badock, Volker, Weiske, Joerg, Puetter, Vera, Holton, Simon J, Stöckigt, Detlef, ter Laak, Antonius, Centrella, Paolo A, Clark, Matthew A, Dumelin, Christoph E, Sigel, Eric A, Soutter, Holly H, Troast, Dawn M, Zhang, Ying, Cuozzo, John W, Keefe, Anthony D, Roche, Didier, Rodeschini, Vincent, Chaikuad, Apirat, Díaz-Sáez, Laura, Bennett, James M, Fedorov, Oleg, Huber, Kilian V. M, Hübner, Jan, Weinmann, Hilmar, Hartung, Ingo V, Gorjánácz, Mátyás

Volltext

Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds von Ramos, Ashley L., Goedken, Eric R., Frank, Kristine E., Argiriadi, Maria A., Bazzaz, Sana, Bian, Zhiguo, Brown, Jesse T. C., Centrella, Paolo A., Chen, Hui-Ju, Disch, Jeremy S., Donner, Pamela L., Duignan, David B., Gikunju, Diana, Greszler, Stephen N., Guié, Marie-Aude, Habeshian, Sevan, Hartl, Hajnalka E., Hein, Christopher D., Hutchins, Charles W., Jetson, Rachael, Keefe, Anthony D., Khan, Hasan, Li, Huan-Qiu, Olszewski, Allison, Ortiz Cardona, Benjamin J., Osuma, Augustine, Panchal, Sanjay C., Phelan, Ryan, Qiu, Wei, Shotwell, J. Brad, Shrestha, Anurupa, Srikumaran, Myron, Su, Zhi, Sun, Chaohong, Upadhyay, Anup K., Wood, Michael D., Wu, Haihong, Zhang, Ruijie, Zhang, Ying, Zhao, Gang, Zhu, Haizhong, Webster, Matthew P.

Volltext

Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT) von Deng, Hongfeng, O’Keefe, Heather, Davie, Christopher P, Lind, Kenneth E, Acharya, Raksha A, Franklin, G. Joseph, Larkin, Jonathan, Matico, Rosalie, Neeb, Michael, Thompson, Monique M, Lohr, Thomas, Gross, Jeffrey W, Centrella, Paolo A, O’Donovan, Gary K, Bedard, Katie L. (Sargent), van Vloten, Kurt, Mataruse, Sibongile, Skinner, Steven R, Belyanskaya, Svetlana L, Carpenter, Tiffany Y, Shearer, Todd W, Clark, Matthew A, Cuozzo, John W, Arico-Muendel, Christopher C, Morgan, Barry A

Volltext

Antiparasitic activities of novel, orally available fumagillin analogs von Arico-Muendel, Christopher, Centrella, Paolo A., Contonio, Brooke D., Morgan, Barry A., O’Donovan, Gary, Paradise, Christopher L., Skinner, Steven R., Sluboski, Barbara, Svendsen, Jennifer L., White, Kerry F., Debnath, Anjan, Gut, Jiri, Wilson, Nathan, McKerrow, James H., DeRisi, Joseph L., Rosenthal, Philip J., Chiang, Peter K.

Volltext

Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl‑1 from a DNA-Encoded Chemical Library Screen von Lucas, Simon C. C., Blackwell, J. Henry, Börjesson, Ulf, Hargreaves, David, Milbradt, Alexander G., Ahmed, Samiyah, Bostock, Mark J., Guerot, Carine, Gohlke, Andrea, Kinzel, Olaf, Lamb, Michelle L., Selmi, Nidhal, Stubbs, Christopher J., Su, Nancy, Su, Qibin, Luo, Haiou, Xiong, Ting, Zuo, Xiaoqian, Bazzaz, Sana, Bienstock, Corey, Centrella, Paolo A., Denton, Kyle E., Gikunju, Diana, Guié, Marie-Aude, Guilinger, John P., Hupp, Christopher, Keefe, Anthony D., Satoh, Takashi, Zhang, Ying, Rivers, Emma L.

Volltext

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl‑1 Inhibitors von Johannes, Jeffrey W., Bates, Stephanie, Beigie, Carl, Belmonte, Matthew A., Breen, John, Cao, Shenggen, Centrella, Paolo A., Clark, Matthew A., Cuozzo, John W., Dumelin, Christoph E., Ferguson, Andrew D., Habeshian, Sevan, Hargreaves, David, Joubran, Camil, Kazmirski, Steven, Keefe, Anthony D., Lamb, Michelle L., Lan, Haiye, Li, Yunxia, Ma, Hao, Mlynarski, Scott, Packer, Martin J., Rawlins, Philip B., Robbins, Daniel W., Shen, Haidong, Sigel, Eric A., Soutter, Holly H., Su, Nancy, Troast, Dawn M., Wang, Haiyun, Wickson, Kate F., Wu, Chengyan, Zhang, Ying, Zhao, Qiuying, Zheng, Xiaolan, Hird, Alexander W.

Volltext