Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework von Cook, David, Brown, Dearg, Alexander, Robert, March, Ruth, Morgan, Paul, Satterthwaite, Gemma, Pangalos, Menelas N.

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Impact of a five-dimensional framework on R&D productivity at AstraZeneca von Morgan, Paul, Brown, Dean G., Lennard, Simon, Anderton, Mark J., Barrett, J. Carl, Eriksson, Ulf, Fidock, Mark, Hamrén, Bengt, Johnson, Anthony, March, Ruth E., Matcham, James, Mettetal, Jerome, Nicholls, David J., Platz, Stefan, Rees, Steve, Snowden, Michael A., Pangalos, Menelas N.

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Implementation of digital health technology in clinical trials: the 6R framework von Durán, Cristina Ortega, Bonam, Matthew, Björk, Elisabeth, Hughes, Rod, Ghiorghiu, Serban, Massacesi, Cristian, Campbell, Alicyn, Hutchison, Emmette, Pangalos, Menelas N., Galbraith, Susan

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Methamphetamine-Evoked Depression of GABAB Receptor Signaling in GABA Neurons of the VTA von Padgett, Claire L., Lalive, Arnaud L., Tan, Kelly R., Terunuma, Miho, Munoz, Michaelanne B., Pangalos, Menelas N., Martínez-Hernández, José, Watanabe, Masahiko, Moss, Stephen J., Luján, Rafael, Lüscher, Christian, Slesinger, Paul A.

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Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice von Gao, Ying, Vasilyev, Dmitry V, Goncalves, Maria Beatriz, Howell, Fiona V, Hobbs, Carl, Reisenberg, Melina, Shen, Ru, Zhang, Mei-Yi, Strassle, Brian W, Lu, Peimin, Mark, Lilly, Piesla, Michael J, Deng, Kangwen, Kouranova, Evguenia V, Ring, Robert H, Whiteside, Garth T, Bates, Brian, Walsh, Frank S, Williams, Gareth, Pangalos, Menelas N, Samad, Tarek A, Doherty, Patrick

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Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease von Jacobsen, J. Steven, Wu, Chi-Cheng, Redwine, Jeffrey M., Comery, Thomas A., Arias, Robert, Bowlby, Mark, Martone, Robert, Morrison, John H., Pangalos, Menelas N., Reinhart, Peter H., Bloom, Floyd E.

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Rapamycin alleviates toxicity of different aggregate-prone proteins von Berger, Zdenek, Ravikumar, Brinda, Menzies, Fiona M., Oroz, Lourdes Garcia, Underwood, Benjamin R., Pangalos, Menelas N., Schmitt, Ina, Wullner, Ullrich, Evert, Bernd O., O'Kane, Cahir J., Rubinsztein, David C.

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Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels von Riddell, David R, Zhou, Hua, Atchison, Kevin, Warwick, Helen K, Atkinson, Peter J, Jefferson, Julius, Xu, Lin, Aschmies, Suzan, Kirksey, Yolanda, Hu, Yun, Wagner, Erik, Parratt, Adrienne, Xu, Jane, Li, Zhuting, Zaleska, Margaret M, Jacobsen, J. Steve, Pangalos, Menelas N, Reinhart, Peter H

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Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system von Chanda, Pranab K, Gao, Ying, Mark, Lilly, Btesh, Joan, Strassle, Brian W, Lu, Peimin, Piesla, Michael J, Zhang, Mei-Yi, Bingham, Brendan, Uveges, Albert, Kowal, Dianne, Garbe, David, Kouranova, Evguenia V, Ring, Robert H, Bates, Brian, Pangalos, Menelas N, Kennedy, Jeffrey D, Whiteside, Garth T, Samad, Tarek A

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Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors von Terunuma, Miho, Vargas, Karina J., Wilkins, Megan E., Ramírez, Omar A., Jaureguiberry-Bravo, Matías, Pangalos, Menelas N., Smart, Trevor G., Moss, Stephen J., Couve, Andrés

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Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons von Robbins, Jacqueline P, Perfect, Leo, Ribe, Elena M, Maresca, Marcello, Dangla-Valls, Adrià, Foster, Evangeline M, Killick, Richard, Nowosiad, Paulina, Reid, Matthew J, Polit, Lucia Dutan, Nevado, Alejo J, Ebner, Daniel, Bohlooly-Y, Mohammad, Buckley, Noel, Pangalos, Menelas N, Price, Jack, Lovestone, Simon

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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility von Douthwaite, Julie A., Brown, Christopher A., Ferdinand, John R., Sharma, Rahul, Elliott, Jane, Taylor, Molly A., Malintan, Nancy T., Duvoisin, Hannah, Hill, Thomas, Delpuech, Oona, Orton, Alexandra L., Pitt, Haidee, Kuenzi, Fred, Fish, Simon, Nicholls, David J., Cuthbert, Anna, Richards, Ian, Ratcliffe, Giles, Upadhyay, Abhishek, Marklew, Abigail, Hewitt, Craig, Ross-Thriepland, Douglas, Brankin, Christopher, Chodorge, Matthieu, Browne, Gareth, Mander, Palwinder K., DeWildt, Ruud M., Weaver, Shane, Smee, Penny A., van Kempen, Joost, Bartlett, Jon G., Allen, Paula M., Koppe, Emma L., Ashby, Charlotte A., Phipps, Julian D., Mehta, Nalini, Brierley, David J., Tew, David G., Leveridge, Melanie V., Baddeley, Stuart M., Goodfellow, Ian G., Green, Clive, Abell, Chris, Neely, Andy, Waddell, Ian, Rees, Steve, Maxwell, Patrick H., Pangalos, Menelas N., Howes, Rob, Clark, Roger

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Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19 von Levin, Myron J., Ustianowski, Andrew, De Wit, Stéphane, Launay, Odile, Avila, Miles, Templeton, Alison, Yuan, Yuan, Seegobin, Seth, Ellery, Adam, Levinson, Dennis J., Ambery, Philip, Arends, Rosalinda H., Beavon, Rohini, Dey, Kanika, Garbes, Pedro, Kelly, Elizabeth J., Koh, Gavin C.K.W., Near, Karen A., Padilla, Kelly W., Psachoulia, Konstantina, Sharbaugh, Audrey, Streicher, Katie, Pangalos, Menelas N., Esser, Mark T.

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Phospho-Dependent Functional Modulation of GABAB Receptors by the Metabolic Sensor AMP-Dependent Protein Kinase von Kuramoto, Nobuyuki, Wilkins, Megan E., Fairfax, Benjamin P., Revilla-Sanchez, Raquel, Terunuma, Miho, Tamaki, Keisuke, Iemata, Mika, Warren, Noel, Couve, Andrés, Calver, Andrew, Horvath, Zsolt, Freeman, Katie, Carling, David, Huang, Lan, Gonzales, Cathleen, Cooper, Edward, Smart, Trevor G., Pangalos, Menelas N., Moss, Stephen J.

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Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine von Falsey, Ann R, Sobieszczyk, Magdalena E, Hirsch, Ian, Sproule, Stephanie, Robb, Merlin L, Corey, Lawrence, Neuzil, Kathleen M, Hahn, William, Hunt, Julie, Mulligan, Mark J, McEvoy, Charlene, DeJesus, Edwin, Hassman, Michael, Little, Susan J, Pahud, Barbara A, Durbin, Anna, Pickrell, Paul, Daar, Eric S, Bush, Larry, Solis, Joel, Carr, Quito Osuna, Oyedele, Temitope, Buchbinder, Susan, Cowden, Jessica, Vargas, Sergio L, Guerreros Benavides, Alfredo, Call, Robert, Keefer, Michael C, Kirkpatrick, Beth D, Pullman, John, Tong, Tina, Brewinski Isaacs, Margaret, Benkeser, David, Janes, Holly E, Nason, Martha C, Green, Justin A, Kelly, Elizabeth J, Maaske, Jill, Mueller, Nancy, Shoemaker, Kathryn, Takas, Therese, Marshall, Richard P, Pangalos, Menelas N, Villafana, Tonya, Gonzalez-Lopez, Antonio

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Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors von Malamas, Michael S, Ni, Yike, Erdei, James, Stange, Hans, Schindler, Rudolf, Lankau, Hans-Joachim, Grunwald, Christian, Fan, Kristi Yi, Parris, Kevin, Langen, Barbara, Egerland, Ute, Hage, Thorsten, Marquis, Karen L, Grauer, Steve, Brennan, Julie, Navarra, Rachel, Graf, Radka, Harrison, Boyd L, Robichaud, Albert, Kronbach, Thomas, Pangalos, Menelas N, Hoefgen, Norbert, Brandon, Nicholas J

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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade von Jacobsen, J. Steven, Comery, Thomas A, Martone, Robert L, Elokdah, Hassan, Crandall, David L, Oganesian, Aram, Aschmies, Suzan, Kirksey, Yolanda, Gonzales, Cathleen, Xu, Jane, Zhou, Hua, Atchison, Kevin, Wagner, Erik, Zaleska, Margaret M, Das, Indranil, Arias, Robert L, Bard, Jonathan, Riddell, David, Gardell, Stephen J, Abou-Gharbia, Magid, Robichaud, Albert, Magolda, Ronald, Vlasuk, George P, Bjornsson, Thorir, Reinhart, Peter H, Pangalos, Menelas N

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Rare variant contribution to human disease in 281,104 UK Biobank exomes von Wang, Quanli, Dhindsa, Ryan S., Carss, Keren, Harper, Andrew R., Nag, Abhishek, Tachmazidou, Ioanna, Vitsios, Dimitrios, Deevi, Sri V. V., Mackay, Alex, Muthas, Daniel, Hühn, Michael, Monkley, Susan, Olsson, Henric, Wasilewski, Sebastian, Smith, Katherine R., March, Ruth, Platt, Adam, Haefliger, Carolina, Petrovski, Slavé

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The development of stroke therapeutics: Promising mechanisms and translational challenges von Zaleska, Margaret M., Mercado, Mary Lynn T., Chavez, Juan, Feuerstein, Giora Z., Pangalos, Menelas N., Wood, Andrew

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Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist von Dunlop, John, Watts, Stephanie W, Barrett, James E, Coupet, Joseph, Harrison, Boyd, Mazandarani, Hossein, Nawoschik, Stanley, Pangalos, Menelas N, Ramamoorthy, Siva, Schechter, Lee, Smith, Deborah, Stack, Gary, Zhang, Jean, Zhang, Guoming, Rosenzweig-Lipson, Sharon

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