Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition von Boudreau, Aaron, Purkey, Hans E, Hitz, Anna, Robarge, Kirk, Peterson, David, Labadie, Sharada, Kwong, Mandy, Hong, Rebecca, Gao, Min, Del Nagro, Christopher, Pusapati, Raju, Ma, Shuguang, Salphati, Laurent, Pang, Jodie, Zhou, Aihe, Lai, Tommy, Li, Yingjie, Chen, Zhongguo, Wei, Binqing, Yen, Ivana, Sideris, Steve, McCleland, Mark, Firestein, Ron, Corson, Laura, Vanderbilt, Alex, Williams, Simon, Daemen, Anneleen, Belvin, Marcia, Eigenbrot, Charles, Jackson, Peter K, Malek, Shiva, Hatzivassiliou, Georgia, Sampath, Deepak, Evangelista, Marie, O'Brien, Thomas

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Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics von An, Le, De Bruyn, Tom, Pang, Jodie, Ubhayakar, Savita, Salphati, Laurent, Zhang, Xing, Liu, Liling, Li, Ruina, Chan, Bryan, Dey, Anwesha, Levy, Elizabeth S

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Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition von Cepa, Steven, Potter, David, Wong, Lisa, Schutt, Leah, Tarrant, Jacqueline, Pang, Jodie, Zhang, Xiaolin, Andaya, Roxanne, Salphati, Laurent, Ran, Yingqing, An, Le, Morgan, Ryan, Maher, Jonathan

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A New Approach for Preparing Stable High-Concentration Peptide Nanoparticle Formulations von Hu, Chloe, Zang, Nanzhi, Tam, Yu Tong, Dizon, Desmond, Lee, Kaylee, Pang, Jodie, Torres, Elizabeth, Cui, Yusi, Yen, Chun-Wan, Leung, Dennis H

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Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer von Sutherlin, Daniel P, Sampath, Deepak, Berry, Megan, Castanedo, Georgette, Chang, Zhigang, Chuckowree, Irina, Dotson, Jenna, Folkes, Adrian, Friedman, Lori, Goldsmith, Richard, Heffron, Tim, Lee, Leslie, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Olivero, Alan, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wiesmann, Christian, Wong, Susan, Zhu, Bing-Yan

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The impact of plasma protein binding on the tissue distribution of warfarin - investigation in nagase analbuminemic rats (NAR) von Pang, Jodie, Chen, John, Cunico, Katherine, Imperio, Jose, Chang, Jae, Ly, Justin

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Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model von Dallas, Shannon, Salphati, Laurent, Gomez-Zepeda, David, Wanek, Thomas, Chen, Liangfu, Chu, Xiaoyan, Kunta, Jeevan, Mezler, Mario, Menet, Marie-Claude, Chasseigneaux, Stephanie, Declèves, Xavier, Langer, Oliver, Pierre, Esaie, DiLoreto, Karen, Hoft, Carolin, Laplanche, Loic, Pang, Jodie, Pereira, Tony, Andonian, Clara, Simic, Damir, Rode, Anja, Yabut, Jocelyn, Zhang, Xiaolin, Scheer, Nico

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Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins von Salphati, Laurent, Chu, Xiaoyan, Chen, Liangfu, Prasad, Bhagwat, Dallas, Shannon, Evers, Raymond, Mamaril-Fishman, Donna, Geier, Ethan G, Kehler, Jonathan, Kunta, Jeevan, Mezler, Mario, Laplanche, Loic, Pang, Jodie, Rode, Anja, Soars, Matthew G, Unadkat, Jashvant D, van Waterschoot, Robert A B, Yabut, Jocelyn, Schinkel, Alfred H, Scheer, Nico

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Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor von Heffron, Timothy P., Berry, Megan, Castanedo, Georgette, Chang, Christine, Chuckowree, Irina, Dotson, Jennafer, Folkes, Adrian, Gunzner, Janet, Lesnick, John D., Lewis, Cristina, Mathieu, Simon, Nonomiya, Jim, Olivero, Alan, Pang, Jodie, Peterson, David, Salphati, Laurent, Sampath, Deepak, Sideris, Steve, Sutherlin, Daniel P., Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wong, Susan, Zhu, Bing-yan

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Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics von Pang, Jodie, Baumgardner, Matthew, Braun, Marie-Gabrielle, Cheong, Jonathan, Edgar, Kyle, Friedman, Lori, Hanan, Emily, Jaochico, Allan, Ma, Shuguang, Plise, Emile, Schmidt, Stephen, Liu, Ning, Song, Kyung, Staben, Steve, Salphati, Laurent

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Structure-based design of thienobenzoxepin inhibitors of PI3-kinase von Staben, Steven T, Siu, Michael, Goldsmith, Richard, Olivero, Alan G, Do, Steven, Burdick, Daniel J, Heffron, Timothy P, Dotson, Jenna, Sutherlin, Daniel P, Zhu, Bing-Yan, Tsui, Vickie, Le, Hoa, Lee, Leslie, Lesnick, John, Lewis, Cristina, Murray, Jeremy M, Nonomiya, Jim, Pang, Jodie, Prior, Wei Wei, Salphati, Laurent, Rouge, Lionel, Sampath, Deepak, Sideris, Steve, Wiesmann, Christian, Wu, Ping

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Absorption, metabolism, and excretion of taselisib (GDC-0032), a PI3K inhibitor, in rats, dogs, and humans von Ma, Shuguang, Salphati, Laurent, Srikumar, Srikumar, Takahashi, Ryan, Ding, Xiao, Pang, Jodie, Wang, Bing, Remarchuk, Travis, Hsu, Jerry, Hop, Cornelis (Marcel), Ware, Joseph A., Khojasteh, S. Cyrus

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Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β -Sparing PI3K Inhibitor in Rats, Dogs, and Humans von Ma, Shuguang, Cho, Sungjoon, Sahasranaman, Srikumar, Zhao, Weiping, Pang, Jodie, Ding, Xiao, Dean, Brian, Wang, Bin, Hsu, Jerry Y, Ware, Joseph, Salphati, Laurent

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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα von Hanan, Emily J., Braun, Marie-Gabrielle, Heald, Robert A., MacLeod, Calum, Chan, Connie, Clausen, Saundra, Edgar, Kyle A., Eigenbrot, Charles, Elliott, Richard, Endres, Nicholas, Friedman, Lori S., Gogol, Emily, Gu, Xiao-Hui, Thibodeau, Rebecca Hong, Jackson, Philip S., Kiefer, James R., Knight, Jamie D., Nannini, Michelle, Narukulla, Raman, Pace, Amanda, Pang, Jodie, Purkey, Hans E., Salphati, Laurent, Sampath, Deepak, Schmidt, Stephen, Sideris, Steve, Song, Kyung, Sujatha-Bhaskar, Swathi, Ultsch, Mark, Wallweber, Heidi, Xin, Jianfeng, Yeap, SiewKuen, Young, Amy, Zhong, Yu, Staben, Steven T.

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GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway von Wallin, Jeffrey J, Edgar, Kyle A, Guan, Jane, Berry, Megan, Prior, Wei Wei, Lee, Leslie, Lesnick, John D, Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Olivero, Alan G, Sutherlin, Daniel P, O'Brien, Carol, Spoerke, Jill M, Patel, Sonal, Lensun, Letitia, Kassees, Robert, Ross, Leanne, Lackner, Mark R, Sampath, Deepak, Belvin, Marcia, Friedman, Lori S

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An Investigation of Oral Exposure Variability and Formulation Strategy: A Case Study of PI3Kδ Inhibitor and Physiologically Based Pharmacokinetic Modeling in Beagle Dogs von Chiang, Po-Chang, Pang, Jodie, Liu, Jia, Salphati, Laurent

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Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatme... von Sutherlin, Daniel P, Bao, Linda, Berry, Megan, Castanedo, Georgette, Chuckowree, Irina, Dotson, Jenna, Folks, Adrian, Friedman, Lori, Goldsmith, Richard, Gunzner, Janet, Heffron, Timothy, Lesnick, John, Lewis, Cristina, Mathieu, Simon, Murray, Jeremy, Nonomiya, Jim, Pang, Jodie, Pegg, Niel, Prior, Wei Wei, Rouge, Lionel, Salphati, Laurent, Sampath, Deepak, Tian, Qingping, Tsui, Vickie, Wan, Nan Chi, Wang, Shumei, Wei, BinQing, Wiesmann, Christian, Wu, Ping, Zhu, Bing-Yan, Olivero, Alan

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Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma von Bronner, Sarah M., Merrick, Karl A., Murray, Jeremy, Salphati, Laurent, Moffat, John G., Pang, Jodie, Sneeringer, Christopher J., Dompe, Nicholas, Cyr, Patrick, Purkey, Hans, Boenig, Gladys de Leon, Li, Jun, Kolesnikov, Aleksandr, Larouche-Gauthier, Robin, Lai, Kwong Wah, Shen, Xiaoli, Aubert-Nicol, Samuel, Chen, Yi-Chen, Cheong, Jonathan, Crawford, James J., Hafner, Marc, Haghshenas, Pouyan, Jakalian, Araz, Leclerc, Jean-Philippe, Lim, Ngiap-Kie, O'Brien, Tom, Plise, Emile G., Shalan, Hadil, Sturino, Claudio, Wai, John, Xiao, Yang, Yin, Jianping, Zhao, Liang, Gould, Stephen, Olivero, Alan, Heffron, Timothy P.

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Discovery of 2‑{3-[2-(1-Isopropyl-3-methyl‑1H‑1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2‑d][1,4]oxazepin-9-yl]‑1H‑pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β‑Sparing... von Ndubaku, Chudi O, Heffron, Timothy P, Staben, Steven T, Baumgardner, Matthew, Blaquiere, Nicole, Bradley, Erin, Bull, Richard, Do, Steven, Dotson, Jennafer, Dudley, Danette, Edgar, Kyle A, Friedman, Lori S, Goldsmith, Richard, Heald, Robert A, Kolesnikov, Aleksandr, Lee, Leslie, Lewis, Cristina, Nannini, Michelle, Nonomiya, Jim, Pang, Jodie, Price, Steve, Prior, Wei Wei, Salphati, Laurent, Sideris, Steve, Wallin, Jeffery J, Wang, Lan, Wei, BinQing, Sampath, Deepak, Olivero, Alan G

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Investigating the Impact of Albumin on the Liver Uptake of Pitavastatin and Warfarin in Nagase Analbuminemic Rats von Chang, Jae H, Chen, Yi-Chen, Cheong, Jonathan, Jones, Robert S, Pang, Jodie

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