DualMET andERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC) von Martinez-Marti, A., Felip, E., Matito, J., Mereu, E., Navarro, A., Cedrés, S., Pardo, N., Martinez de Castro, A., Remon, J., Miquel, J.M., Guillaumet-Adkins, A., Nadal, E., Rodriguez-Esteban, G., Arqués, O., Fasani, R., Nuciforo, P., Heyn, H., Villanueva, A., Palmer, H.G., Vivancos, A.

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687 Beta-catenin Confers Resistance to PI3K and AKT Inhibitors and Subverts FOXO3a to Promote Metastasis in Colon Cancer von Tenbaum, S.P, Ordóñez-Morán, P, Puig, I, Chicote, I, Arqués, O, Vivancos, A, Baselga, J, Tabernero, J, Muñoz, A, Palmer, H.G

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626P Mucinous differentiation (MD) as predictor of response in BRAF-V600E mutated metastatic colorectal cancer (mCRC) treated with BRAF inhibitors (BRAFi) combinations von Ros Montana, F.J., Navarro, V., Comas, R., Landolfi, S., Ramirez, L., Palmer, H.G., Garcia Rodriguez, A., Saoudi Gonzalez, N., Baraibar Argota, I., Rodriguez Castells, M., Salvà Ballabrera, F., Tabernero, J., Elez Fernandez, M.E.

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2211MO Uncovering the mechanisms of persistent disease in RET-altered thyroid cancers: Insights from patient-derived xenograft models treated with selective RET inhibitors von Alvarez, A. Garcia, Hernando, J., Chicote, I., Martínez-Quintanilla, J., Carmona, A., Iglesias, C., Serres Créixams, X., Jimenez, J., Nuciforo, P.G., Izquierdo, S. Aguilar, Gonzalo, J., Vivancos, A., Palmer, H.G., Capdevila Castillon, J.

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445P Tumor load surrogates as major prognostic factors in BRAF-V600E mutated (mt) colorectal (CRC) patients treated with BRAF inhibitor+antiEGFR +/- MEK inhibitor von Montana, F.J. Ros, Martini, G., Javierre, G. Villacampa, Baraibar, I., Comas, R., Garcia, A., Salva, F., Gonzalez, N. Saoudi, Ciardiello, D., Toledo, R.D.A., Martinelli, E., Ciardiello, F., Vivancos, A., Palmer, H.G., Dienstmann, R., Tabernero, J., Fernandez, M.E. Elez

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SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150 von Barbáchano, A, Fernández-Barral, A, Pereira, F, Segura, M F, Ordóñez-Morán, P, Carrillo-de Santa Pau, E, González-Sancho, J M, Hanniford, D, Martínez, N, Costales-Carrera, A, Real, F X, Pálmer, H G, Rojas, J M, Hernando, E, Muñoz, A

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1381O - RNA expression profiles and splicing alterations in grade 1/2 neuroendocrine neoplasms from small intestine origin (siNENs). Final results of the GETNE-NETSEQ study von Capdevila, J., Castaño, J.P., Mancuso, F.M., Pedraza-Arevalo, S., Matos, I., Palmer, H.G., Salva, F., Landolfi, S., Jimenez-Fonseca, P., Garcia-Carbonero, R., Lopez, C., Ogbah, Z., Nuciforo, P.G., Casteras, A., Acosta, D., Diez, M., Hernando, J., Luque, R.M., Vivancos, A.

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1989P - WNT pathway mutations (APC/CTNNB1) and immune checkpoint inhibitors (ICI) response in metastatic non-small cell lung cancer (NSCLC) patients von Ros Montana, F.J., Iranzo, P., Pedrola, A., Callejo, A., Pardo, N., Amat, R., Carbonell, C., Martinez, A., Navarro, A., Cedres, S., Dienstmann, R., Palmer, H.G., Vivancos, A., Felip, E.

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RNA expression profiles and splicing alterations in grade 1/2 neuroendocrine neoplasms from small intestine origin (siNENs). Final results of the GETNE-NETSEQ study von Capdevila, J., Castaño, J.P., Mancuso, F.M., Pedraza-Arevalo, S., Matos, I., Palmer, H.G., Salva, F., Landolfi, S., Jimenez-Fonseca, P., Garcia-Carbonero, R., Lopez, C., Ogbah, Z., Nuciforo, P.G., Casteras, A., Acosta, D., Diez, M., Hernando, J., Luque, R.M., Vivancos, A.

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WNT pathway mutations (APC/CTNNB1) and immune checkpoint inhibitors (ICI) response in metastatic non-small cell lung cancer (NSCLC) patients von Ros Montana, F.J., Iranzo, P., Pedrola, A., Callejo, A., Pardo, N., Amat, R., Carbonell, C., Martinez, A., Navarro, A., Cedres, S., Dienstmann, R., Palmer, H.G., Vivancos, A., Felip, E.

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SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer von Ordóñez-Morán, P, Irmisch, A, Barbáchano, A, Chicote, I, Tenbaum, S, Landolfi, S, Tabernero, J, Huelsken, J, Muñoz, A, Pálmer, H G

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Establishment of patient-derived tumor organoids to functionally inform treatment decisions in metastatic colorectal cancer von Martini, G., Belli, V., Napolitano, S., Ciaramella, V., Ciardiello, D., Belli, A., Izzo, F., Avallone, A., Selvaggi, F., Menegon Tasselli, F., Santaniello, W., Franco, R., Puig, I., Ramirez, L., Chicote, I., Mancuso, F., Caratu, G., Serres, X., Fasani, R., Jimenez, J., Ros, J., Baraibar, I., Mulet, N., Della Corte, C.M., Troiani, T., Vivancos, A., Dienstmann, R., Elez, E., Palmer, H.G., Tabernero, J., Martinelli, E., Ciardiello, F., Argilés, G.

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SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity von Barbáchano, A, Ordóñez-Morán, P, García, J M, Sánchez, A, Pereira, F, Larriba, M J, Martínez, N, Hernández, J, Landolfi, S, Bonilla, F, Pálmer, H G, Rojas, J M, Muñoz, A

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Prognostic impact of RNA expression profile (EP) in the phase III DECISION trial for patients with advanced radioactive-iodine refractory differentiated thyroid cancer (DTC) von Matos, I., Mancuso, F., Iglesias, C., Nuciforo, P., Zafón, C., Palmer, H.G., Ogbah, Z., Muños, L., Villacampa Javierre, G., Peña, C., Brose, M.S., Schlumberger, M., Vivancos, A., Capdevila, J.

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FGFR 360° resistance: Establishing a translational research framework in FGFR-altered (FGFRalt) patients (pt) treated with fibroblast growth factor receptor inhibitors (FGFRinh) von Hierro, C., Sánchez-Guixé, M., Ruiz-Pace, F., Jimenez, J., Maynes, L., Azaro, A., Martin-Liberal, J., Ochoa de Olza, M., Braña, I., Vieito, M., Villanueva, A., Palmer, H.G., Arribas, J., Nuciforo, P., Vivancos, A., Garralda, E., Dienstmann, R., Tabernero, J., Serra, V., Rodon, J.

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668 Vitamin D receptor and colon cancer: effect of the Snail family of transcription factors von Larriba, M.J, Pereira, F, Barbáchano, A, Pálmer, H.G, Bonilla, F, Muñoz, A

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DICKKOPF-4 is induced by TCF/(β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin [D.sub.3.]... von Pendas-Franco, N, Garcia, J.M, Pena, C, Valle, N, Palmer, H.G, Heinaniemi, M, Carlberg, C, Jimenez, B, Bonilla, F, Munoz, A, Gonzalez-Sancho, J.M

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MOTOR CONTROL von PALMER, NORMAN H.G

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Letters to the editor von Seaman, E.F., Roach, C.L., Palmer, H.G., Rhodes, D.

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Letters to the editor von Seaman, E.F., Roach, C.L., Palmer, H.G., Rhodes, D.

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