Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Ki... von Cui, J. Jean, Tran-Dubé, Michelle, Shen, Hong, Nambu, Mitchell, Kung, Pei-Pei, Pairish, Mason, Jia, Lei, Meng, Jerry, Funk, Lee, Botrous, Iriny, McTigue, Michele, Grodsky, Neil, Ryan, Kevin, Padrique, Ellen, Alton, Gordon, Timofeevski, Sergei, Yamazaki, Shinji, Li, Qiuhua, Zou, Helen, Christensen, James, Mroczkowski, Barbara, Bender, Steve, Kania, Robert S, Edwards, Martin P

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Systematic Structure Modifications of Imidazo[1,2-a]pyrimidine to Reduce Metabolism Mediated by Aldehyde Oxidase (AO) von Linton, Angelica, Kang, Ping, Ornelas, Martha, Kephart, Susan, Hu, Qiyue, Pairish, Mason, Jiang, Ying, Guo, Chuangxing

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Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2‑(4-(1-... von Cui, J. Jean, McTigue, Michele, Nambu, Mitchell, Tran-Dubé, Michelle, Pairish, Mason, Shen, Hong, Jia, Lei, Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Jalaie, Mehran, Goetz, Gilles H, Ryan, Kevin, Grodsky, Neil, Deng, Ya-li, Parker, Max, Timofeevski, Sergei, Murray, Brion W, Yamazaki, Shinji, Aguirre, Shirley, Li, Qiuhua, Zou, Helen, Christensen, James

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Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists von Guo, Chuangxing, Linton, Angelica, Kephart, Susan, Ornelas, Martha, Pairish, Mason, Gonzalez, Javier, Greasley, Samantha, Nagata, Asako, Burke, Benjamin J, Edwards, Martin, Hosea, Natilie, Kang, Ping, Hu, Wenyue, Engebretsen, Jon, Briere, David, Shi, Manli, Gukasyan, Hovik, Richardson, Paul, Dack, Kevin, Underwood, Toby, Johnson, Patrick, Morell, Andrew, Felstead, Robert, Kuruma, Hidetoshi, Matsimoto, Hiroaki, Zoubeidi, Amina, Gleave, Martin, Los, Gerrit, Fanjul, Andrea N

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The Antibody Registry: ten years of registering antibodies von Bandrowski, Anita, Pairish, Mason, Eckmann, Peter, Grethe, Jeffrey, Martone, Maryann E

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Discovery of 3-aryloxy-lactam analogs as potent androgen receptor full antagonists for treating castration resistant prostate cancer von Guo, Chuangxing, Kephart, Susan, Ornelas, Martha, Gonzalez, Javier, Linton, Angelica, Pairish, Mason, Nagata, Asako, Greasley, Samantha, Elleraas, Jeff, Hosea, Natilie, Engebretsen, Jon, Fanjul, Andrea N.

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Desi... von Planken, Simon, Behenna, Douglas C, Nair, Sajiv K, Johnson, Theodore O, Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G, Dinh, Dac M, Edwards, Martin P, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle, Kania, Robert S, Kath, John C, Matthews, Jean, Murray, Brion W, Niessen, Sherry, Orr, Suvi T. M, Pairish, Mason, Sach, Neal W, Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L, Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer

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Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195) von Cheng, Hengmiao, Orr, Suvi T. M., Bailey, Simon, Brooun, Alexei, Chen, Ping, Deal, Judith G., Deng, Yali L., Edwards, Martin P., Gallego, Gary M., Grodsky, Neil, Huang, Buwen, Jalaie, Mehran, Kaiser, Stephen, Kania, Robert S., Kephart, Susan E., Lafontaine, Jennifer, Ornelas, Martha A., Pairish, Mason, Planken, Simon, Shen, Hong, Sutton, Scott, Zehnder, Luke, Almaden, Chau D., Bagrodia, Shubha, Falk, Matthew D., Gukasyan, Hovhannes J., Ho, Caroline, Kang, Xiaolin, Kosa, Rachel E., Liu, Ling, Spilker, Mary E., Timofeevski, Sergei, Visswanathan, Ravi, Wang, Zhenxiong, Meng, Fanxiu, Ren, Shijian, Shao, Li, Xu, Feng, Kath, John C.

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Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-... von Cui, J. Jean, McTigue, Michele, Nambu, Mitchell, Tran-Dubé, Michelle, Pairish, Mason, Shen, Hong, Jia, Lei, Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Jalaie, Mehran, Goetz, Gilles H., Ryan, Kevin, Grodsky, Neil, Deng, Ya-li, Parker, Max, Timofeevski, Sergei, Murray, Brion W., Yamazaki, Shinji, Aguirre, Shirley, Li, Qiuhua, Zou, Helen, Christensen, James

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Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Pote... von Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C

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Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators von Guo, Chuangxing, Linton, Angelica, Jalaie, Mehran, Kephart, Susan, Ornelas, Martha, Pairish, Mason, Greasley, Samantha, Richardson, Paul, Maegley, Karen, Hickey, Michael, Li, John, Wu, Xin, Ji, Xiaodong, Xie, Zhi

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Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series von Cheng, Hengmiao, Hoffman, Jacqui E., Le, Phuong T., Pairish, Mason, Kania, Robert, Farrell, William, Bagrodia, Shubha, Yuan, Jing, Sun, Shaoxian, Zhang, Eric, Xiang, Cathy, Dalvie, Deepak, Rahavendran, Sadayappan V.

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Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists von Guo, Chuangxing, Pairish, Mason, Linton, Angelica, Kephart, Susan, Ornelas, Martha, Nagata, Asako, Burke, Benjamin, Dong, Liming, Engebretsen, Jon, Fanjul, Andrea N.

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Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based... von Planken, Simon, Behenna, Douglas C., Nair, Sajiv K., Johnson, Theodore O., Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie, Deepak, Deal, Judith G., Dinh, Dac M., Edwards, Martin P., Ferre, Rose Ann, Gajiwala, Ketan S., Hemkens, Michelle, Kania, Robert S., Kath, John C., Matthews, Jean, Murray, Brion W., Niessen, Sherry, Orr, Suvi T. M., Pairish, Mason, Sach, Neal W., Shen, Hong, Shi, Manli, Solowiej, James, Tran, Khanh, Tseng, Elaine, Vicini, Paolo, Wang, Yuli, Weinrich, Scott L., Zhou, Ru, Zientek, Michael, Liu, Longqing, Luo, Yiqin, Xin, Shuibo, Zhang, Chengyi, Lafontaine, Jennifer

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An efficient synthesis of highly functionalized chiral lactams von Ornelas, Martha A., Gonzalez, Javier, Sach, Neal W., Richardson, Paul F., Bunker, Kevin D., Linton, Angelica, Kephart, Susan E., Pairish, Mason, Guo, Chuangxing

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Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drugadrug interaction von Palmer, Cynthia, Pairish, Mason, Kephart, Susan, Bouzida, Djamal, Cui, Jingrong, Deal, Judith, Dong, Liming, Gu, Danlin, Linton, Angelica, McAlpine, Indrawan, Yamazaki, Shinji, Smith, Evan, John-Baptiste, Annette, Bagrodia, Shubha, Kania, Robert, Guo, Chuangxing

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Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug–drug interaction von Palmer, Cynthia, Pairish, Mason, Kephart, Susan, Bouzida, Djamal, Cui, Jingrong, Deal, Judith, Dong, Liming, Gu, Danlin, Linton, Angelica, McAlpine, Indrawan, Yamazaki, Shinji, Smith, Evan, John-Baptiste, Annette, Bagrodia, Shubha, Kania, Robert, Guo, Chuangxing

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Correction to Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Cand... von Cui, J. Jean, McTigue, Michele, Nambu, Mitchell, Tran-Dubé, Michelle, Pairish, Mason, Shen, Hong, Jia, Lei, Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Jalaie, Mehran, Goetz, Gilles H., Koenig, Marcel, Vojkovsky, Tomas, Zhang, Fang-Jie, Do, Steven, Botrous, Iriny, Ryan, Kevin, Grodsky, Neil, Deng, Ya-li, Parker, Max, Timofeevski, Sergei, Murray, Brion W., Yamazaki, Shinji, Aguirre, Shirley, Li, Qiuhua, Zou, Helen, Christensen, James

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Artificial β-sheets von Nowick, James S., Smith, Eric M., Pairish, Mason

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An Extended β-Strand Mimic for a Larger Artificial β-Sheet von Nowick, James S, Pairish, Mason, Lee, In Quen, Holmes, Darren L, Ziller, Joseph W

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