Targeting oncogenic Notch signaling with SERCA inhibitors von Pagliaro, Luca, Marchesini, Matteo, Roti, Giovanni

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Targeting Notch Trafficking and Processing in Cancers von Pagliaro, Luca, Sorrentino, Claudia, Roti, Giovanni

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Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML von Marchesini, Matteo, Gherli, Andrea, Simoncini, Elisa, Tor, Lucas Moron Dalla, Montanaro, Anna, Thongon, Natthakan, Vento, Federica, Liverani, Chiara, Cerretani, Elisa, D’Antuono, Anna, Pagliaro, Luca, Zamponi, Raffaella, Spadazzi, Chiara, Follini, Elena, Cambò, Benedetta, Giaimo, Mariateresa, Falco, Angela, Sammarelli, Gabriella, Todaro, Giannalisa, Bonomini, Sabrina, Adami, Valentina, Piazza, Silvano, Corbo, Claudia, Lorusso, Bruno, Mezzasoma, Federica, Lagrasta, Costanza Anna Maria, Martelli, Maria Paola, La Starza, Roberta, Cuneo, Antonio, Aversa, Franco, Mecucci, Cristina, Quaini, Federico, Colla, Simona, Roti, Giovanni

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S239: SOX11 DRIVES B1A LINEAGE COMMITMENT AND B1A/MCL‐LIKE LYMPHOMA FORMATION IN MICE von Pieters, Tim, Pagliaro, Luca, Ntziachristos, Panagiotis, Van Vlierberghe, Pieter, Goossens, Steven

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Identification of an Epi-metabolic dependency on EHMT2/G9a in T-cell acute lymphoblastic leukemia von Montanaro, Anna, Kitara, Samuel, Cerretani, Elisa, Marchesini, Matteo, Rompietti, Chiara, Pagliaro, Luca, Gherli, Andrea, Su, Angela, Minchillo, Maria Laura, Caputi, Mariafrancesca, Fioretzaki, Rodanthi, Lorusso, Bruno, Ross, Linda, Alexe, Gabriela, Masselli, Elena, Marozzi, Marina, Rizzi, Federica Maria Angela, La Starza, Roberta, Mecucci, Cristina, Xiong, Yan, Jin, Jian, Falco, Angela, Knoechel, Birgit, Aversa, Franco, Candini, Olivia, Quaini, Federico, Sportoletti, Paolo, Stegmaier, Kimberly, Roti, Giovanni

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Morphological, clinical, and molecular profiling of post-polycythemia vera accelerated/blast phase occurring with and without antecedent secondary myelofibrosis von Pelagatti, Laura, Pozzi, Giulia, Cortellazzi, Samuele, Mancini, Cristina, Martella, Eugenia, Pagliaro, Luca, Giaimo, Mariateresa, Roti, Giovanni, Vitale, Marco, Carubbi, Cecilia, Masselli, Elena

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Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T‐cell lymphoblastic leukemia von Almeida, André, T'Sas, Sara, Pagliaro, Luca, Fijalkowski, Igor, Sleeckx, Wouter, Van Steenberge, Hannah, Zamponi, Raffaella, Lintermans, Béatrice, Van Loocke, Wouter, Palhais, Bruno, Reekmans, Alexandra, Bardelli, Valentina, Demoen, Lisa, Reunes, Lindy, Deforce, Dieter, Van Nieuwerburgh, Filip, Kentsis, Alex, Ntziachristos, Panagiotis, Van Roy, Nadine, De Moerloose, Barbara, Mecucci, Cristina, La Starza, Roberta, Roti, Giovanni, Goossens, Steven, Van Vlierberghe, Pieter, Pieters, Tim

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Discovery of a new 1-(phenylsulfonyl)-1H-indole derivative targeting the EphA2 receptor with antiproliferative activity on U251 glioblastoma cell line von Guidetti, Lorenzo, Castelli, Riccardo, Zappia, Alfonso, Ferrari, Francesca Romana, Giorgio, Carmine, Barocelli, Elisabetta, Pagliaro, Luca, Vento, Federica, Roti, Giovanni, Scalvini, Laura, Vacondio, Federica, Rivara, Silvia, Mor, Marco, Lodola, Alessio, Tognolini, Massimiliano

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The Atypical Protein Kinase WNK1 Controls Leukemia Progression in TAL/LMO T-Cell Acute Lymphoblastic Leukemia von Montanaro, Anna, D'Antuono, Anna, Moron Dalla Tor, Lucas, Andrei, Pietro, Cavazzini, Filippo, Cerretani, Elisa, Vento, Federica, Simoncini, Elisa, Gherli, Andrea, Zamponi, Raffaella, Lorusso, Bruno, Todaro, Giannalisa, Giaimo, Mariateresa, La Starza, Roberta, Mecucci, Cristina, Sammarelli, Gabriella, Marchesini, Matteo, Pagliaro, Luca, Roti, Giovanni

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Identification of the Atypical Protein Kinase WNK1 As a New Target in T-Cell Acute Lymphoblastic Leukemia von Montanaro, Anna, D'Antuono, Anna, Moron Dalla Tor, Lucas, Andrei, Pietro, Ciringione, Alessia, Cerretani, Elisa, Vento, Federica, Pagliaro, Luca, Gherli, Andrea, Lorusso, Bruno, Simoncini, Elisa, Zamponi, Raffaella, Salvatori, Costanza, Todaro, Giannalisa, La Starza, Roberta, Mecucci, Cristina, Sammarelli, Gabriella, Marchesini, Matteo, Roti, Giovanni

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Orthogonal Proteogenomic Approaches Identify the Druggable PA2G4-MYC Axis in 3q26 AML von Marchesini, Matteo, Gherli, Andrea, Simoncini, Elisa, Montanaro, Anna, Thongon, Natthakan, Pagliaro, Luca, Vento, Federica, Moron Dalla Tor, Lucas, Liverani, Chiara, Zamponi, Raffaella, Follini, Elena, Cambò, Benedetta, Lorusso, Bruno, La Starza, Roberta, Cuneo, Antonio, Mecucci, Cristina, Colla, Simona, Quaini, Federico, Roti, Giovanni

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Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia von Marchesini, Matteo, Gherli, Andrea, Montanaro, Anna, Patrizi, Laura, Sorrentino, Claudia, Pagliaro, Luca, Rompietti, Chiara, Kitara, Samuel, Heit, Sabine, Olesen, Claus E., Møller, Jesper V., Savi, Monia, Bocchi, Leonardo, Vilella, Rocchina, Rizzi, Federica, Baglione, Marilena, Rastelli, Giorgia, Loiacono, Caterina, La Starza, Roberta, Mecucci, Cristina, Stegmaier, Kimberly, Aversa, Franco, Stilli, Donatella, Lund Winther, Anne-Marie, Sportoletti, Paolo, Bublitz, Maike, Dalby-Brown, William, Roti, Giovanni

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CAD204520 Targets NOTCH1 PEST Domain Mutations in Lymphoproliferative Disorders von Pagliaro, Luca, Cerretani, Elisa, Vento, Federica, Montanaro, Anna, Moron Dalla Tor, Lucas, Simoncini, Elisa, Giaimo, Mariateresa, Gherli, Andrea, Zamponi, Raffaella, Tartaglione, Isotta, Lorusso, Bruno, Scita, Matteo, Russo, Filomena, Sammarelli, Gabriella, Todaro, Giannalisa, Silini, Enrico Maria, Rigolin, Gian Matteo, Quaini, Federico, Cuneo, Antonio, Roti, Giovanni

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The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor for secondary myelofibrosis and biomarker of disease severity von Masselli, Elena, Carubbi, Cecilia, Cambò, Benedetta, Pozzi, Giulia, Gobbi, Giuliana, Mirandola, Prisco, Follini, Elena, Pagliaro, Luca, Di Marcantonio, Daniela, Bonatti, Francesco, Percesepe, Antonio, Sykes, Stephen M., Aversa, Franco, Vitale, Marco

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CAD204520 Targets INOTCH1/I PEST Domain Mutations in Lymphoproliferative Disorders von Pagliaro, Luca, Cerretani, Elisa, Vento, Federica, Montanaro, Anna, Moron Dalla Tor, Lucas, Simoncini, Elisa, Giaimo, Mariateresa, Gherli, Andrea, Zamponi, Raffaella, Tartaglione, Isotta, Lorusso, Bruno, Scita, Matteo, Russo, Filomena, Sammarelli, Gabriella, Todaro, Giannalisa, Silini, Enrico Maria, Rigolin, Gian Matteo, Quaini, Federico, Cuneo, Antonio, Roti, Giovanni

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Acute lymphoblastic leukaemia von Pagliaro, Luca, Chen, Sai-Juan, Herranz, Daniel, Mecucci, Cristina, Harrison, Christine J., Mullighan, Charles G., Zhang, Ming, Chen, Zhu, Boissel, Nicolas, Winter, Stuart S., Roti, Giovanni

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Higher Monocyte Chemoattractant Protein-1 Levels in Myelofibrosis Are Sustained By the rs1024611 Single Nucleotide Polymorphism and Correlate with Disease Subtype and Severity von Masselli, Elena, Pozzi, Giulia, Carubbi, Cecilia, Pagliaro, Luca, Follini, Elena, Cambò, Benedetta, Crugnola, Monica, Gobbi, Giuliana, Mirandola, Prisco, Aversa, Franco, Vitale, Marco

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Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520 von Marchesini, Matteo, Gherli, Andrea, Montanaro, Anna, Kitara, Samuel, Sorrentino, Claudia, Pagliaro, Luca, Lund Winter, Anne-Marie, Rompietti, Chiara, Stilli, Donatella, Rizzi, Federica, Stegmaier, Kimberly, Sportoletti, Paolo, Dalby-Brown, William, Roti, Giovanni

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Abstract B113: Selective blockade of oncogenic NOTCH1 with the new SERCA inhibitor CAD204520 in T-cell acute lymphoblastic leukemia von Matteo, Marchesini, Gherli, Andrea, Winter, Anne-Marie Lund, Kitara, Samuel, Montanaro, Anna, Rompietti, Chiara, Sorrentino, Claudia, Stilli, Donatella, Rizzi, Federica, Pagliaro, Luca, Stegmaier, Kimberly, Dalby-Brown, William, Roti, Giovanni

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The -2518A/G (rs1026411) Regulatory Region Polymorphism of the Monocyte Chemoattractant Protein-1 (MCP-1) Is Associated with Secondary Myelofibrosis von Masselli, Elena, Carubbi, Cecilia, Cambò, Benedetta, Pozzi, Giulia, Gobbi, Giuliana, Mirandola, Prisco, Follini, Elena, Pagliaro, Luca, Bonatti, Francesco, Percesepe, Antonio, Aversa, Franco, Vitale, Marco

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