NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine von Valerie, Nicholas C K, Hagenkort, Anna, Page, Brent D G, Masuyer, Geoffrey, Rehling, Daniel, Carter, Megan, Bevc, Luka, Herr, Patrick, Homan, Evert, Sheppard, Nina G, Stenmark, Pål, Jemth, Ann-Sofie, Helleday, Thomas

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The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase von Heppler, Lisa N., Attarha, Sanaz, Persaud, Rosanne, Brown, Jennifer I., Wang, Peng, Petrova, Boryana, Tošić, Isidora, Burton, Foster B., Flamand, Yael, Walker, Sarah R., Yeh, Jennifer E., Zubarev, Roman A., Gaetani, Massimiliano, Kanarek, Naama, Page, Brent D.G., Frank, David A.

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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells von Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas

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Validating Signal Transducer and Activator of Transcription (STAT) Protein–Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays von Attarha, Sanaz, Reithmeier, Anja, Busker, Sander, Desroses, Matthieu, Page, Brent D. G

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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 von Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål

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The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1 von Brown, Jennifer I., Page, Brent D.G., Frankel, Adam

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Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens von Brown, Jennifer I, Persaud, Rosanne, Iliev, Petar, Karmacharya, Ujjwala, Attarha, Sanaz, Sahile, Henok, Olsen, Jonas E, Hanke, Danielle, Idowu, Temilolu, Frank, David A, Frankel, Adam, Williams, Karla C, Page, Brent D G

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TSLP as druggable target – a silver-lining for atopic diseases? von Adhikary, Partho Protim, Tan, Zheng, Page, Brent D.G., Hedtrich, Sarah

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir von Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas

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Development of a chemical probe against NUDT15 von Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C. K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas

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Identification of novel small molecules that inhibit STAT3-dependent transcription and function von Kolosenko, Iryna, Yu, Yasmin, Busker, Sander, Dyczynski, Matheus, Liu, Jianping, Haraldsson, Martin, Palm Apergi, Caroline, Helleday, Thomas, Tamm, Katja Pokrovskaja, Page, Brent D G, Grander, Dan

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STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions von Desroses, Matthieu, Busker, Sander, Astorga-Wells, Juan, Attarha, Sanaz, Kolosenko, Iryna, Zubarev, Roman A., Helleday, Thomas, Grandér, Dan, Page, Brent D.G.

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Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death von Busker, S, Qian, W, Haraldsson, M, Espinosa, B, Johansson, L, Attarha, S, Kolosenko, I, Liu, J, Dagnell, M, Grandér, D, Arnér, E S J, Tamm, K Pokrovskaja, Page, B D G

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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018) von Page, BDG, Valerie, NCK, Wright, RHG, Wallner, O, Isaksson, R, Carter, M, Rudd, SG, Loseva, O, Jemth, A-S, Almlof, I

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Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells von Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas

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N-Aryl-substituted 3-( beta -D-glucopyranosyloxy)-2-methyl-4(1H)-pyridinoiies as agents for Alzheimer's therapy von Scott, LE, Telpoukhovskaia, M, Rodriguez-Rodriguez, C, Merkel, M, Bowen, M L, Page, BDG, Green, DE, Storr, T, Thomas, F, Allen, D D, Lockman, PR, Patrick, BO, Adam, MJ, Orvig, C

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