Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia von Packer, Leisl M., Rana, Sareena, Hayward, Robert, O'Hare, Thomas, Eide, Christopher A., Rebocho, Ana, Heidorn, Sonja, Zabriskie, Matthew S., Niculescu-Duvaz, Ion, Druker, Brian J., Springer, Caroline, Marais, Richard

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Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer von Bonazzi, Vanessa F, Kondrashova, Olga, Smith, Deborah, Nones, Katia, Sengal, Asmerom T, Ju, Robert, Packer, Leisl M, Koufariotis, Lambros T, Kazakoff, Stephen H, Davidson, Aimee L, Ramarao-Milne, Priya, Lakis, Vanessa, Newell, Felicity, Rogers, Rebecca, Davies, Claire, Nicklin, James, Garrett, Andrea, Chetty, Naven, Perrin, Lewis, Pearson, John V, Patch, Ann-Marie, Waddell, Nicola, Pollock, Pamela M

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Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer von Packer, Leisl M., Stehbens, Samantha J., Bonazzi, Vanessa F., Gunter, Jennifer H., Ju, Robert J., Ward, Micheal, Gartside, Michael G., Byron, Sara A., Pollock, Pamela M.

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PI3K Inhibitors Synergize with FGFR Inhibitors to Enhance Antitumor Responses in FGFR2mutant Endometrial Cancers von Packer, Leisl M., Geng, Xinyan, Bonazzi, Vanessa F., Ju, Robert J., Mahon, Clare E., Cummings, Margaret C., Stephenson, Sally-Anne, Pollock, Pamela M.

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Paralog-Specific Kinase Inhibition of FGFR4: Adding to the Arsenal of Anti-FGFR Agents von Packer, Leisl M, Pollock, Pamela M

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Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence von DE KEIZER, Peter L. J, PACKER, Leisl M, SZYPOWSKA, Anna A, RIEDL-POLDERMAN, Paulien E, VAN DEN BROEK, Niels J. F, DE BRUIN, Alain, DANSEN, Tobias B, MARAIS, Richard, BRENKMAN, Arjan B, BURGERING, Boudewijn M. T

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Identification of direct transcriptional targets of V600EBRAF/MEK signalling in melanoma von Packer, Leisl M, East, Philip, Reis-Filho, Jorge S, Marais, Richard

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Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma von Packer, Leisl M, East, Philip, Reis-Filho, Jorge S, Marais, Richard

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Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF von Packer, Leisl M., Pavey, Sandra J., Boyle, Glen M., Stark, Mitchell S., Ayub, Ana L., Rizos, Helen, Hayward, Nicholas K.

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Expression of MUC1 splice variants in benign and malignant ovarian tumours von Obermair, Andreas, Schmid, Bernd C., Packer, Leisl M., Leodolter, Sepp, Birner, Peter, Ward, Bruce G., Crandon, Alex J., McGuckin, Michael A., Zeillinger, Robert

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Abstract PR007: Genomic characterization of endometrial cancer patient-derived xenografts reveals intratumor heterogeneity von Kondrashova, Olga, Bonazzi, Vanessa F., Smith, Deborah, Nones, Katia, Sengal, Asmerom, Ju, Robert, Packer, Leisl M., Koufariotis, Lambros T, Kazakoff, Stephen H., Davidson, Aimee L., Ramarao-Milne, Priya, Lakis, Vanessa, Newell, Felicity, Rogers, Rebecca, Davies, Claire, Chetty, Naven, Perrin, Lewis, Pearson, John, Patch, Ann-Marie, Garrett, Andrea, Waddell, Nicola, Pollock, Pamela, Nicklin, James

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Abstract 1715: Elucidating mechanisms of resistance to FGFR inhibitors in endometrial cancer von Packer, Leisl M., Byron, Sara, Loch, David, Dehkhoda, Farhad, Wortmann, Andreas, Geng, Xinyan, Nones, Katia, Grimmond, Sean, Pearson, John, Waddell, Nic, Pollock, Pamela

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PI3K Inhibitors Synergize with FGFR Inhibitors to Enhance Antitumor Responses in FGFR2 mutant Endometrial Cancers von Packer, Leisl M, Geng, Xinyan, Bonazzi, Vanessa F, Ju, Robert J, Mahon, Clare E, Cummings, Margaret C, Stephenson, Sally-Anne, Pollock, Pamela M

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Identification of direct transcriptional targets of V600E BRAF/MEK signalling in melanoma von Packer, Leisl M, East, Philip, Reis‐Filho, Jorge S, Marais, Richard

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Activation of FOXO transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence von de Keizer, Peter L.J., Packer, Leisl M., Szypowska, Anna A., Riedl-Polderman, Paulien E., van den Broek, Niels J.F., de Bruin, Alain, Dansen, Tobias B., Marais, Richard, Brenkman, Arjan B., Burgering, Boudewijn M.T.

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Gene expression profiling in melanoma identifies novel downstream effectors of pI4ARF von PACKER, Leisl M, PAVEY, Sandra J, BOYLE, Glen M, STARK, Mitchell S, AYUB, Ana L, RIZOS, Helen, HAYWARD, Nicholas K

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Additional file 2 of Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer von Bonazzi, Vanessa F., Kondrashova, Olga, Smith, Deborah, Nones, Katia, Sengal, Asmerom T., Ju, Robert, Packer, Leisl M., Koufariotis, Lambros T., Kazakoff, Stephen H., Davidson, Aimee L., Ramarao-Milne, Priya, Lakis, Vanessa, Newell, Felicity, Rogers, Rebecca, Davies, Claire, Nicklin, James, Garrett, Andrea, Chetty, Naven, Perrin, Lewis, Pearson, John V., Patch, Ann-Marie, Waddell, Nicola, Pollock, Pamela M.

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Microarray expression profiling in melanoma reveals a BRAF mutation signature von PAVEY, Sandra, JOHANSSON, Peter, HANSEN, Katherine, YUDT, Laura, SCHMIDT, Chris, HERSEY, Peter, ELLEM, Kay A. O, O'ROURKE, Michael G. E, PARSONS, Peter G, MELTZER, Paul, RINGNER, Markus, HAYWARD, Nicholas K, PACKER, Leisl, TAYLOR, Jennifer, STARK, Mitchell, POLLOCK, Pamela M, WALKER, Graeme J, BOYLE, Glen M, HARPER, Ursula, COZZI, Sarah-Jane

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Abstract B114: Combination of BGJ398 with either a pan-PI3K inhibitor or a specific PIK3CA inhibitor shows synergy in FGFR2 mutant endometrial cancer cell lines von Pollock, Pamela M., Geng, Xinyan, Bonazzi, Vanessa F., Mahon, Clare, Stephenson, Sally, Packer, Leisl

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Abstract LB-B31: FGFR inhibition in endometrial cancer induces caspase-independent cell death that can be augmented with ABT-737 von Packer, Leisl, Byron, Sara, Stehbens, Samantha, Bonazzi, Vanessa, Loch, David, Wortmann, Andreas, Gartside, Mike, Waterhouse, Nigel, Gunter, Jennifer, Pollock, Pamela M.

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