Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point von Darman, Rachel B., Seiler, Michael, Agrawal, Anant A., Lim, Kian H., Peng, Shouyong, Aird, Daniel, Bailey, Suzanna L., Bhavsar, Erica B., Chan, Betty, Colla, Simona, Corson, Laura, Feala, Jacob, Fekkes, Peter, Ichikawa, Kana, Keaney, Gregg F., Lee, Linda, Kumar, Pavan, Kunii, Kaiko, MacKenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eun Sun, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael P., Tsai, Jennifer, Wang, John Y., Warmuth, Markus, Yang, Hui, Zhu, Ping, Garcia-Manero, Guillermo, Furman, Richard R., Yu, Lihua, Smith, Peter G., Buonamici, Silvia

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex von Teng, Teng, Tsai, Jennifer HC, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Prajapati, Sudeep, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Gerard, Baudouin, Karr, Craig, Korpal, Manav, Liu, Xiang, T. Lowe, Jason, Mizui, Yoshiharu, Palacino, James, Park, Eunice, Smith, Peter G., Subramanian, Vanitha, Wu, Zhenhua Jeremy, Zou, Jian, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping

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Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer von Korpal, Manav, Puyang, Xiaoling, Jeremy Wu, Zhenhua, Seiler, Roland, Furman, Craig, Oo, Htoo Zarni, Seiler, Michael, Irwin, Sean, Subramanian, Vanitha, Julie Joshi, Jaya, Wang, Chris K., Rimkunas, Victoria, Tortora, Davide, Yang, Hua, Kumar, Namita, Kuznetsov, Galina, Matijevic, Mark, Chow, Jesse, Kumar, Pavan, Zou, Jian, Feala, Jacob, Corson, Laura, Henry, Ryan, Selvaraj, Anand, Davis, Allison, Bloudoff, Kristjan, Douglas, James, Kiss, Bernhard, Roberts, Morgan, Fazli, Ladan, Black, Peter C., Fekkes, Peter, Smith, Peter G., Warmuth, Markus, Yu, Lihua, Hao, Ming-Hong, Larsen, Nicholas, Daugaard, Mads, Zhu, Ping

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Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication von BORAWSKI, Jason, TROKE, Philip, BARYZA, Jeremy, TALLARICO, John, JOBERTY, Gerard, BANTSCHEFF, Marcus, SCHIRLE, Markus, BOUWMEESTER, Tewis, MATHY, Joanna E, KAI LIN, COMPTON, Teresa, LABOW, Mark, XIAOLING PUYANG, WIEDMANN, Brigitte, GAITHER, L. Alex, GIBAJA, Veronica, SHANCHAUN ZHAO, MICKANIN, Craig, LEIGHTON-DAVIES, Juliet, WILSON, Christopher J, MYER, Vic, CORNELLATARACIDO, Ivan

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Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer von Korpal, Manav, Puyang, Xiaoling, Wu, Zhenhua Jeremy, Seiler, Roland, Furman, Craig, Oo, Htoo Zarni, Seiler, Michael, Irwin, Sean, Subramanian, Vanitha, Joshi, Jaya Julie, Wang, Chris K., Rimkunas, Victoria, Tortora, Davide, Yang, Hua, Kumar, Namita, Kuznetsov, Galina, Matijevic, Mark, Chow, Jesse, Kumar, Pavan, Zou, Jian, Feala, Jacob, Corson, Laura, Henry, Ryan, Selvaraj, Anand, Davis, Allison, Bloudoff, Kristjan, Douglas, James, Kiss, Bernhard, Roberts, Morgan, Fazli, Ladan, Black, Peter C., Fekkes, Peter, Smith, Peter G., Warmuth, Markus, Yu, Lihua, Hao, Ming-Hong, Larsen, Nicholas, Daugaard, Mads, Zhu, Ping

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NAMPT Is the Cellular Target of STF-31-Like Small-Molecule Probes von Adams, Drew J, Ito, Daisuke, Rees, Matthew G, Seashore-Ludlow, Brinton, Puyang, Xiaoling, Ramos, Alex H, Cheah, Jaime H, Clemons, Paul A, Warmuth, Markus, Zhu, Ping, Shamji, Alykhan F, Schreiber, Stuart L

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Mechanism of Resistance of Hepatitis C Virus Replicons to Structurally Distinct Cyclophilin Inhibitors von Puyang, Xiaoling, Poulin, Danielle L, Mathy, Joanna E, Anderson, Leah J, Ma, Sue, Fang, Zheng, Zhu, Shejin, Lin, Kai, Fujimoto, Roger, Compton, Teresa, Wiedmann, Brigitte

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The Alternative Sigma Factor SigH Regulates Major Components of Oxidative and Heat Stress Responses in Mycobacterium tuberculosis von Raman, S, Song, T, Puyang, X, Bardarov, S, Jacobs, Jr, W R, Husson, R N

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Mycobacterium tuberculosis SigM Positively Regulates Esx Secreted Protein and Nonribosomal Peptide Synthetase Genes and Down Regulates Virulence-Associated Surface Lipid Synthesis von RAMAN, Sahadevan, XIAOLING PUYANG, CHENG, Tan-Yun, YOUNG, David C, MOODY, D. Branch, HUSSON, Robert N

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Role of the AcrAB-TolC Efflux Pump in Determining Susceptibility of Haemophilus influenzae to the Novel Peptide Deformylase Inhibitor LBM415 von DEAN, Charles R, NARAYAN, Shubha, RYDER, Neil S, DAIGLE, Denis M, DZINK-FOX, Joann L, XIAOLING PUYANG, BRACKEN, Kathryn R, DEAN, Karl E, WEIDMANN, Beat, ZHENGYU YUAN, JAIN, Rakesh

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Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay von Parker, Mackenzie J., Lee, Hyelee, Yao, Shihua, Irwin, Sean, Hwang, Sunil, Belanger, Kylie, de Mare, Sofia Woo, Surgenor, Richard, Yan, Lu, Gee, Patricia, Morla, Shravan, Puyang, Xiaoling, Hsiao, Peng, Zeng, Hao, Zhu, Ping, Korpal, Manav, Dransfield, Paul, Bolduc, David M., Larsen, Nicholas A.

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A Mycobacterial Extracytoplasmic Sigma Factor Involved in Survival following Heat Shock and Oxidative Stress von Fernandes, N D, Wu, Q L, Kong, D, Puyang, X, Garg, S, Husson, R N

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Two-Dimensional Direct-Reading Fluorescence Spectrograph for DNA Sequencing by Capillary Array Electrophoresis von Zhang, Jianzhong, Yang, Minjian, Puyang, Xiaoling, Fang, Yu, Cook, Lillian M, Dovichi, Norman J

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Reduced Susceptibility of Haemophilus influenzae to the Peptide Deformylase Inhibitor LBM415 Can Result from Target Protein Overexpression Due to Amplified Chromosomal def Gene Cop... von CHARLES, R, NARAYAN, Shubha, VOSHOL, Hans, VAN OOSTRUM, Jan, WALL, Daniel, KOEHN, James, DZINK-FOX, Joann, RYDER, Neil S, RICHARDS, Joel, DAIGLE, Denis M, ESTEROW, Stacy, LEEDS, Jennifer A, KAMP, Heather, PUYANG, Xiaoling, WIEDMANN, Brigitte, MUELLER, Dieter

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Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer von Furman, Craig, Puyang, Xiaoling, Zhang, Zhaojie, Wu, Zhenhua J, Banka, Deepti, Aithal, Kiran B, Albacker, Lee A, Hao, Ming-Hong, Irwin, Sean, Kim, Amy, Montesion, Meagan, Moriarty, Alyssa D, Murugesan, Karthikeyan, Nguyen, Tuong-Vi, Rimkunas, Victoria, Sahmoud, Tarek, Wick, Michael J, Yao, Shihua, Zhang, Xun, Zeng, Hao, Vaillancourt, Frédéric H, Bolduc, David M, Larsen, Nicholas, Zheng, Guo Zhu, Prajapati, Sudeep, Zhu, Ping, Korpal, Manav

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Abstract PS12-23: Development of H3B-6545, a first-in-class oral selective ER covalent antagonist (SERCA), for the treatment of ERaWT and ERaMUT breast cancer von Korpal, Manav, Furman, Craig, Puyang, Xiaoling, Zhang, Zhaojie, Wu, Zhenhua, Banka, Deepti, Das, Subhasree, Destenaves, Benoit, Gao, Lei, Hamilton, Erika, Hao, Ming-Hong, Irwin, Sean, Johnston, Stephen, Joshi, Jaya J, Juric, Dejan, Kim, Amy, Nguyen, Tuong-Vi, Pipas, Marc, Pluard, Timothy, Rimkunas, Victoria, Rioux, Nathalie, Schindler, Joanne, Smith, Peter, Thomas, Michael, Wang, John, Wang, Judy S, Warmuth, Markus, Yao, Huilan, Yao, Shihua, Yu, Lihua, Vaillancourt, Frédéric H, Bolduc, David M, Larsen, Nicholas A, Zheng, GuoZhu, Prajapati, Sudeep, Sahmoud, Tarek, Gualberto, Antonio, Zhu, Ping

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IS1626, a new IS900-related Mycobacterium avium insertion sequence von Puyang, Xiaoling, Lee, Karen, Pawlichuk, Corey, Kunimoto, Dennis Y

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Abstract 3013: Identification of PHF5A as a common cellular target of splicing-modulating chemical probes von Teng, Teng, Puyang, Xiaoling, Peng, Shouyong, Feala, Jacob, Chan, Betty, Tsai, Jennifer, Caleb, Benjamin, Karr, Craig, Park, Eunice, Corson, Laura, Mizui, Yoshiharu, Smith, Peter, Larsen, Nicholas, Yu, Lihua, Warmuth, Markus, Zhu, Ping, Chicas, Agustin

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Abstract 126: A chemogenomic approach reveals the action of splicing modulators at the branch point adenosine binding pocket defined by the PHF5A/SF3b complex von Teng, Teng, Tsai, Jennifer, Puyang, Xiaoling, Seiler, Michael, Peng, Shouyong, Aird, Daniel, Buonamici, Silvia, Caleb, Benjamin, Chan, Betty, Corson, Laura, Feala, Jacob, Fekkes, Peter, Karr, Craig, Korpal, Manav, Mizui, Yoshiharu, Park, Eunice, Palacino, James, Smith, Peter, Subramanian, Vanitha, Wu, Jeremy, Yu, Lihua, Chicas, Agustin, Warmuth, Markus, Larsen, Nicholas, Zhu, Ping

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Abstract DDT01-04: Discovery and development of H3B-6545: A novel, oral, selective estrogen receptor covalent antagonist (SERCA) for the treatment of breast cancer von Smith, Peter G., Puyang, Xiaoling, Furman, Craig, Zheng, Guo Zhu, Banka, Deepti, Thomas, Michael, Subramanian, Vanitha, Irwin, Sean, Larsen, Nicholas, Caleb, Benjamin, Karr, Craig, Wu, Jeremy, O’Shea, Morgan, Yang, Joyce, Davis, Allison, Kim, Amy, Rioux, Nathalie, Rimkunas, Victoria, Yao, Huilan, MacKenzie, Crystal, Kumar, Pavan, Smith, Sherri, Eckley, Sean, Hart, Andrew, Lai, George, Rowbottom, Christopher, Fekkes, Peter, Buonamici, Silvia, Reynolds, Dominic, Yu, Lihua, Sahmoud, Tarek, Warmuth, Markus, Mitchell, Lorna, Zhu, Ping, Korpal, Manav

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