Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis von Morris, Elizabeth R., Caswell, Sarah J., Kunzelmann, Simone, Arnold, Laurence H., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.

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Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 von Rzechorzek, Neil J., Kunzelmann, Simone, Purkiss, Andrew G., Silva Dos Santos, Mariana, MacRae, James I., Taylor, Ian A., Fugger, Kasper, West, Stephen C.

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d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition von de Chiara, Cesira, Homšak, Miha, Prosser, Gareth A., Douglas, Holly L., Garza-Garcia, Acely, Kelly, Geoff, Purkiss, Andrew G., Tate, Edward W., de Carvalho, Luiz Pedro S.

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Structure of the cohesin loader Scc2 von Chao, William C. H., Murayama, Yasuto, Muñoz, Sofía, Jones, Andrew W., Wade, Benjamin O., Purkiss, Andrew G., Hu, Xiao-Wen, Borg, Aaron, Snijders, Ambrosius P., Uhlmann, Frank, Singleton, Martin R.

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Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization von Gori, Ilaria, George, Roger, Purkiss, Andrew G, Strohbuecker, Stephanie, Randall, Rebecca A, Ogrodowicz, Roksana, Carmignac, Virginie, Faivre, Laurence, Joshi, Dhira, Kjær, Svend, Hill, Caroline S

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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing von Adams, Sarah E., Purkiss, Andrew G., Knowles, Phillip P., Nans, Andrea, Briggs, David C., Borg, Annabel, Earl, Christopher P., Goodman, Kerry M., Nawrotek, Agata, Borg, Aaron J., McIntosh, Pauline B., Houghton, Francesca M., Kjær, Svend, McDonald, Neil Q.

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RET Recognition of GDNF-GFRα1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association von Goodman, Kerry M., Kjær, Svend, Beuron, Fabienne, Knowles, Phillip P., Nawrotek, Agata, Burns, Emily M., Purkiss, Andrew G., George, Roger, Santoro, Massimo, Morris, Edward P., McDonald, Neil Q.

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Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp‑dNTPαS Diastereomers von Morris, Elizabeth R, Kunzelmann, Simone, Caswell, Sarah J, Purkiss, Andrew G, Kelly, Geoff, Taylor, Ian A

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Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R p - and S p -dNTPαS Diastereomers von Morris, Elizabeth R, Kunzelmann, Simone, Caswell, Sarah J, Purkiss, Andrew G, Kelly, Geoff, Taylor, Ian A

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IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties von Dagil, Robert, Ball, Neil J, Ogrodowicz, Roksana W, Hobor, Fruzsina, Purkiss, Andrew G, Kelly, Geoff, Martin, Stephen R, Taylor, Ian A, Ramos, Andres

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The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity von Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

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Structural Basis of Eco1-Mediated Cohesin Acetylation von Chao, William C. H., Wade, Benjamin O., Bouchoux, Céline, Jones, Andrew W., Purkiss, Andrew G., Federico, Stefania, O’Reilly, Nicola, Snijders, Ambrosius P., Uhlmann, Frank, Singleton, Martin R.

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Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove von Ivanova, Marina E., Fletcher, Georgina C., O'Reilly, Nicola, Purkiss, Andrew G., Thompson, Barry J., McDonald, Neil Q.

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Urochordate βγ-Crystallin and the Evolutionary Origin of the Vertebrate Eye Lens von Shimeld, Sebastian M., Purkiss, Andrew G., Dirks, Ron P.H., Bateman, Orval A., Slingsby, Christine, Lubsen, Nicolette H.

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Erratum: Structural Basis of Eco1-Mediated Cohesin Acetylation von Chao, William C. H., Wade, Benjamin O., Bouchoux, Céline, Jones, Andrew W., Purkiss, Andrew G., Federico, Stefania, O’Reilly, Nicola, Snijders, Ambrosius P., Uhlmann, Frank, Singleton, Martin R.

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Deamidation in Human γS-Crystallin from Cataractous Lenses Is Influenced by Surface Exposure von Lapko, Veniamin N, Purkiss, Andrew G, Smith, David L, Smith, Jean B

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Sulfur in human crystallins von Srikanthan, Durga, Bateman, Orval A., Purkiss, Andrew G., Slingsby, Christine

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Simulated dynamics and biological macromolecules von Moraitakis, George, Purkiss, Andrew G, Goodfellow, Julia M

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Specific interaction between lens MIP/Aquaporin-0 and two members of the gamma-crystallin family von Fan, Jianguo, Fariss, Robert N, Purkiss, Andrew G, Slingsby, Christine, Sandilands, Aileen, Quinlan, Roy, Wistow, Graeme, Chepelinsky, Ana B

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The X-ray Crystal Structure of Human γS-crystallin C-terminal Domain von Purkiss, Andrew G., Bateman, Orval A., Goodfellow, Julia M., Lubsen, Nicolette H., Slingsby, Christine

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