Intratumoral delivery of TransCon™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction von Zúñiga, Luis Alejandro, Leßmann, Torben, Uppal, Karan, Bisek, Nicola, Hong, Enping, Rasmussen, Caroline E., Karlsson, Jens-Jakob, Zettler, Joachim, Holten-Andersen, Lars, Bang, Kathy, Thakar, Dhruv, Lee, Yu-Chi, Martinez, Salomon, Sabharwal, Simran Singh, Stark, Sebastian, Faltinger, Frank, Kracker, Oliver, Weisbrod, Samuel, Müller, Robin, Voigt, Tobias, Bigott, Kornelia, Tabrizifard, Mohammad, Breinholt, Vibeke Miller, Mirza, Amer M., Rosen, David B., Sprogøe, Kennett, Punnonen, Juha

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TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune... von Rosen, David B, Kvarnhammar, Anne Månsson, Laufer, Burkhardt, Knappe, Thomas, Karlsson, Jens Jakob, Hong, Enping, Lee, Yu-Chi, Thakar, Dhruv, Zúñiga, Luis Alejandro, Bang, Kathy, Sabharwal, Simran Singh, Uppal, Karan, Olling, Janne Damm, Kjaergaard, Kristian, Kurpiers, Thomas, Schnabel, Meike, Reich, Diana, Glock, Philipp, Zettler, Joachim, Krusch, Mathias, Bernhard, Ana, Heinig, Stefan, Konjik, Valentino, Wegge, Thomas, Hehn, Yvonne, Killian, Steffen, Viet, Laura, Runz, Josefine, Faltinger, Frank, Tabrizi, Mohammad, Abel, Kristin Laura, Breinholt, Vibeke Miller, Singel, Stina M, Sprogøe, Kennett, Punnonen, Juha

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16 Tumor growth inhibition mediated by a single dose of intratumoral TransCon™ TLR7/8 agonist was associated with activated circulating T and B cells and sustained low levels of sy... von Mirza, Amer, Zuniga, Luis, Uppal, Karan, Bang, Kathy, Hong, Enping, Sabharwal, Simran, Lee, Yuchi, Martinez, Salomon, Rosen, David, Punnonen, Juha

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Antitumor efficacy of combined CTLA4/PD-1 blockade without intestinal inflammation is achieved by elimination of FcγR interactions von Bauché, David, Mauze, Smita, Kochel, Christina, Grein, Jeff, Sawant, Anandi, Zybina, Yulia, Blumenschein, Wendy, Yang, Peng, Annamalai, Lakshmanan, Yearley, Jennifer H, Punnonen, Juha, Bowman, Edward P, Chackerian, Alissa, Laface, Drake

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769 A single dose of intratumoral TransCon™ TLR7/8 agonist monotherapy promoted sustained activation of antigen presenting cells resulting in CD4+ and CD8+ T cell activation and tu... von Zuniga, Luis, Uppal, Karan, Bang, Kathy, Hong, Enping, Sabharwal, Simran, Lee, Yuchi, Martinez, Solomon, Rosen, David, Mirza, Amer, Punnonen, Juha

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Pro-and Anti-inflammatory Cytokines in Rheumatoid Arthritis von Isomäki, Pia, Punnonen, Juha

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Hypoallergens for Allergen-specific Immunotherapy by Directed Molecular Evolution of Mite Group 2 Allergens von Gafvelin, Guro, Parmley, Stephen, Neimert-Andersson, Theresa, Blank, Ulrich, Eriksson, Tove L.J., van Hage, Marianne, Punnonen, Juha

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Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes von Punnonen, J, Cocks, B G, Carballido, J M, Bennett, B, Peterson, D, Aversa, G, de Vries, J E

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Optimized Expression and Specific Activity of IL-12 by Directed Molecular Evolution von Leong, Steven R., Jean C. C. Chang, Ong, Randal, Dawes, Glenn, Willem P. C. Stemmer, Punnonen, Juha

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Diverse plasmid DNA vectors by directed molecular evolution of cytomegalovirus promoters von WRIGHT, Anne, SEMYONOV, Andrey, DAWES, Glenn, CRAMERI, Andreas, LYONS, Rick, STEMMER, Willem P. C, APT, Doris, PUNNONEN, Juha

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TransCon IL-2 β/γ, a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 analog, demonstrates improved pharmacokinetics and profound expansion of cytotox... von Rosen, David, Månsson Kvarnhammar, Anne, Olling, Janne Damm, Laufer, Burkhardt, Knappe, Thomas, Karlsson, Jens Jakob, Kurpiers, Thomas, Zettler, Joachim, Runz, Josefine, Faltinger, Frank, Viet, Laura, Krusch, Mathias, Schnabel, Meike, Reich, Diana, Glock, Philipp, Singel, Stina Mui, Sprogøe, Kennett, Abel, Kristin Laura, Breinholt, Vibeke Miller, Punnonen, Juha

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Abstract 4507: TransConTM IL-2 β/γ: a novel long-acting prodrug of receptor-biased IL-2 designed for improved pharmocokinetics and optimal activation of T cells for the treatment o... von Rosen, David Brian, Laufer, Burkhardt, Knappe, Thomas, Schnabel, Meike, Begaliew, Diana, Zettler, Joachim, Krusch, Mathias, Bernhard, Ana, Heinig, Stefan, Konjik, Valentino, Wegge, Thomas, Breinholt, Vibeke, Tabrizi, Mohammad, Sprogoe, Kennett, Punnonen, Juha

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Erythropoietin and small molecule agonists of the tissue-protective erythropoietin receptor increase FXN expression in neuronal cells in vitro and in Fxn-deficient KIKO mice in viv... von Miller, James L., Rai, Myriam, Frigon, Normand L., Pandolfo, Massimo, Punnonen, Juha, Spencer, Jeffrey R.

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Cytokine Therapeutics in Cancer Immunotherapy: Design and Development von Punnonen, Juha, Rosen, David, Zuniga, Luis, Sprogøe, Kennett, Tabrizi, Mohammad

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Chimeric Co-stimulatory Molecules That Selectively Act through CD28 or CTLA-4 on Human T Cells von Lazetic, Sasha, Leong, Steven R., Chang, Jean C-C., Ong, Randal, Dawes, Glenn, Punnonen, Juha

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Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin Receptor von Miller, James L., Church, Timothy J., Leonoudakis, Dmitri, Lariosa-Willingham, Karen, Frigon, Normand L., Tettenborn, Connie S., Spencer, Jeffrey R., Punnonen, Juha

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Monocyte-Derived CD1a+ and CD1a- Dendritic Cell Subsets Differ in Their Cytokine Production Profiles, Susceptibilities to Transfection, and Capacities to Direct Th Cell Differentia... von Chang, Chia-Chun J, Wright, Anne, Punnonen, Juha

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Characterization of murine CEACAM1 in vivo reveals low expression on CD8 + T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1 von McLeod, Robbie L, Angagaw, Minilik H, Baral, Toya Nath, Liu, Liming, Moniz, Raymond Joseph, Laskey, Jason, Hsieh, SuChun, Lee, Mike, Han, Jin-Hwan, Issafras, Hassan, Javaid, Sarah, Loboda, Andrey, Sadekova, Svetlana, O'Connor, Joann A, Tse, Archie, Punnonen, Juha

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A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques von Raviprakash, Kanakatte, Apt, Doris, Brinkman, Alice, Skinner, Craig, Yang, Shumin, Dawes, Glenn, Ewing, Dan, Wu, Shuenn-Jue, Bass, Steve, Punnonen, Juha, Porter, Kevin

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Tetravalent neutralizing antibody response against four dengue serotypes by a single chimeric dengue envelope antigen von Apt, Doris, Raviprakash, Kanakatte, Brinkman, Alice, Semyonov, Andrey, Yang, Shumin, Skinner, Craig, Diehl, Lori, Lyons, Richard, Porter, Kevin, Punnonen, Juha

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