Pancreatic β-cell identity, glucose sensing and the control of insulin secretion von Rutter, Guy A, Pullen, Timothy J, Hodson, David J, Martinez-Sanchez, Aida

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miR-29a and miR-29b Contribute to Pancreatic β-Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1) von Pullen, Timothy J., da Silva Xavier, Gabriela, Kelsey, Gavin, Rutter, Guy A.

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The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells von Tarasov, Andrei I, Semplici, Francesca, Ravier, Magalie A, Bellomo, Elisa A, Pullen, Timothy J, Gilon, Patrick, Sekler, Israel, Rizzuto, Rosario, Rutter, Guy A

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The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice von Georgiadou, Eleni, Haythorne, Elizabeth, Dickerson, Matthew T., Lopez-Noriega, Livia, Pullen, Timothy J., da Silva Xavier, Gabriela, Davis, Samuel P. X., Martinez-Sanchez, Aida, Semplici, Francesca, Rizzuto, Rosario, McGinty, James A., French, Paul M., Cane, Matthew C., Jacobson, David A., Leclerc, Isabelle, Rutter, Guy A.

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Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression von Denton, Richard M, Pullen, Timothy J, Armstrong, Craig T, Heesom, Kate J, Rutter, Guy A

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Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity von Rutter, Guy A., Georgiadou, Eleni, Martinez-Sanchez, Aida, Pullen, Timothy J.

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Roles of lncRNAs in pancreatic beta cell identity and diabetes susceptibility von Pullen, Timothy J, Rutter, Guy A

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Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells von NOORDEEN, Nafeesa A, KHERA, Tarnjit K, GAO SUN, REBECCA LONGBOTTOM, E, PULLEN, Timothy J, DA SILVA XAVIER, Gabriela, RUTTER, Guy A, LECLERC, Isabelle

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Identification of genes selectively disallowed in the pancreatic islet von Pullen, Timothy J., Khan, Arshad M., Barton, Geraint, Butcher, Sarah A., Sun, Gao, Rutter, Guy A.

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The role of long non-coding RNAs in the regulation of pancreatic beta cell identity von Wilson, Maya E, Pullen, Timothy J

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Local and regional control of calcium dynamics in the pancreatic islet von Rutter, Guy A., Hodson, David J., Chabosseau, Pauline, Haythorne, Elizabeth, Pullen, Timothy J., Leclerc, Isabelle

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Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study von Slieker, Roderick C., Donnelly, Louise A., Fitipaldi, Hugo, Bouland, Gerard A., Giordano, Giuseppe N., Åkerlund, Mikael, Gerl, Mathias J., Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Festa, Andreas, Hansen, Michael K., Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J., Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido-Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W., Ibberson, Mark, Rutter, Guy A., Beulens, Joline W. J., ‘t Hart, Leen M., Pearson, Ewan R.

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Analysis of Purified Pancreatic Islet Beta and Alpha Cell Transcriptomes Reveals 11β-Hydroxysteroid Dehydrogenase (Hsd11b1) as a Novel Disallowed Gene von Pullen, Timothy J, Huising, Mark O, Rutter, Guy A

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The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice von Mitchell, Ryan K., Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Callingham, Rebecca M., Pullen, Timothy J., Cheung, Rebecca, Leclerc, Isabelle, Hodson, David J., Rutter, Guy A.

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Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes: An IMI-RHAPSODY Study von Slieker, Roderick C, Donnelly, Louise A, Fitipaldi, Hugo, Bouland, Gerard A, Giordano, Giuseppe N, Åkerlund, Mikael, Gerl, Mathias J, Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Elders, Petra, Festa, Andreas, Hansen, Michael K, van der Heijden, Amber A, Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J, Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W, Ibberson, Mark, Rutter, Guy A, Beulens, Joline W J, 't Hart, Leen M, Pearson, Ewan R

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ADCY5 Couples Glucose to Insulin Secretion in Human Islets von HODSON, David J, MITCHELL, Ryan K, LAVALLARD, Vanessa, BOSCO, Domenico, PIEMONTI, Lorenzo, JOHNSON, Paul R, HUGHES, Stephen J, DALIANG LI, LI, Wen-Hong, SHAPIRO, A. M. James, RUTTER, Guy A, MARSELLI, Lorella, PULLEN, Timothy J, BRIAS, Silvia Gimeno, SEMPLICI, Francesca, EVERETT, Katy L, COOPER, Dermot M. F, BUGLIANI, Marco, MARCHETTI, Piero

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Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function von Yavari, Arash, Stocker, Claire J., Ghaffari, Sahar, Wargent, Edward T., Steeples, Violetta, Czibik, Gabor, Pinter, Katalin, Bellahcene, Mohamed, Woods, Angela, Martínez de Morentin, Pablo B., Cansell, Céline, Lam, Brian Y.H., Chuster, André, Petkevicius, Kasparas, Nguyen-Tu, Marie-Sophie, Martinez-Sanchez, Aida, Pullen, Timothy J., Oliver, Peter L., Stockenhuber, Alexander, Nguyen, Chinh, Lazdam, Merzaka, O’Dowd, Jacqueline F., Harikumar, Parvathy, Tóth, Mónika, Beall, Craig, Kyriakou, Theodosios, Parnis, Julia, Sarma, Dhruv, Katritsis, George, Wortmann, Diana D.J., Harper, Andrew R., Brown, Laurence A., Willows, Robin, Gandra, Silvia, Poncio, Victor, de Oliveira Figueiredo, Márcio J., Qi, Nathan R., Peirson, Stuart N., McCrimmon, Rory J., Gereben, Balázs, Tretter, László, Fekete, Csaba, Redwood, Charles, Yeo, Giles S.H., Heisler, Lora K., Rutter, Guy A., Smith, Mark A., Withers, Dominic J., Carling, David, Sternick, Eduardo B., Arch, Jonathan R.S., Cawthorne, Michael A., Watkins, Hugh, Ashrafian, Houman

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Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic β-cells Leads to Relative Hyperinsulinism During Exercise von PULLEN, Timothy J, SYLOW, Lykke, GAO SUN, HALESTRAP, Andrew P, RICHTER, Erik A, RUTTER, Guy A

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Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo von Salem, Victoria, Silva, Luis Delgadillo, Suba, Kinga, Georgiadou, Eleni, Neda Mousavy Gharavy, S., Akhtar, Nadeem, Martin-Alonso, Aldara, Gaboriau, David C. A., Rothery, Stephen M., Stylianides, Theodoros, Carrat, Gaelle, Pullen, Timothy J., Singh, Sumeet Pal, Hodson, David J., Leclerc, Isabelle, Shapiro, A. M. James, Marchetti, Piero, Briant, Linford J. B., Distaso, Walter, Ninov, Nikolay, Rutter, Guy A.

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Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice von Carrat, Gaelle R., Hu, Ming, Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Gaulton, Kyle J., van de Bunt, Martijn, Siddiq, Afshan, Falchi, Mario, Thurner, Matthias, Canouil, Mickaël, Pattou, Francois, Leclerc, Isabelle, Pullen, Timothy J., Cane, Matthew C., Prabhala, Priyanka, Greenwald, William, Schulte, Anke, Marchetti, Piero, Ibberson, Mark, MacDonald, Patrick E., Manning Fox, Jocelyn E., Gloyn, Anna L., Froguel, Philippe, Solimena, Michele, McCarthy, Mark I., Rutter, Guy A.

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