Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer von Ma, Shenghong, Tang, Tracy, Probst, Gary, Konradi, Andrei, Jin, Chunyu, Li, Fulong, Gutkind, J. Silvio, Fu, Xiang-Dong, Guan, Kun-Liang

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious fa... von Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan

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Novel cinnoline-based inhibitors of LRRK2 kinase activity von Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Bowers, Simeon, Franzini, Maurizio, Goldbach, Erich, Lorentzen, Colin, Neitz, R. Jeffrey, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

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Triazolopyridazine LRRK2 kinase inhibitors von Franzini, Maurizio, Ye, Xiaocong M., Adler, Marc, Aubele, Danielle L., Garofalo, Albert W., Gauby, Shawn, Goldbach, Erich, Probst, Gary D., Quinn, Kevin P., Santiago, Pam, Sham, Hing L., Tam, Danny, Truong, Anh, Ren, Zhao

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Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors von Garofalo, Albert W., Adler, Marc, Aubele, Danielle L., Brigham, Elizabeth F., Chian, David, Franzini, Maurizio, Goldbach, Erich, Kwong, Grace T., Motter, Ruth, Probst, Gary D., Quinn, Kevin P., Ruslim, Lany, Sham, Hing L., Tam, Danny, Tanaka, Pearl, Truong, Anh P., Ye, Xiaocong M., Ren, Zhao

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model von Truong, Anh P., Tóth, Gergley, Probst, Gary D., Sealy, Jennifer M., Bowers, Simeon, Wone, David W.G., Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Wu, Jing, Peterson, Brian T., Ruslim, Lany, Bova, Michael P., Kholodenko, Dora, Motter, Ruth N., Bard, Frédérique, Santiago, Pamela, Ni, Huifang, Chian, David, Soriano, Ferdie, Cole, Tracy, Brigham, Elizabeth F., Wong, Karina, Zmolek, Wes, Goldbach, Erich, Samant, Bhushan, Chen, Linda, Zhang, Hongbing, Nakamura, David F., Quinn, Kevin P., Yednock, Ted A., Sauer, John-Michael

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors von Ng, Raymond A., Sun, Minghua, Bowers, Simeon, Hom, Roy K., Probst, Gary D., John, Varghese, Fang, Lawrence Y., Maillard, Michel, Gailunas, Andrea, Brogley, Louis, Neitz, R. Jeffrey, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Adler, Marc, Yao, Nanhua, Zmolek, Wes, Nakamura, David, Quinn, Kevin P., Sauer, John-Michael, Bova, Michael P., Ruslim, Lany, Artis, Dean R., Yednock, Ted A.

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Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor von Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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A Formal Synthesis of (−)-Mycalamide A von Trost, Barry M, Yang, Hanbiao, Probst, Gary D

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Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration von Bowers, Simeon, Truong, Anh P., Jeffrey Neitz, R., Hom, Roy K., Sealy, Jennifer M., Probst, Gary D., Quincy, David, Peterson, Brian, Chan, Wayman, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Lin, May, Yao, Nanhua, Artis, Dean R., Zhang, Heather, Chen, Linda, Dryer, Mark, Samant, Bhushan, Zmolek, Wes, Wong, Karina, Lorentzen, Colin, Goldbach, Erich, Tonn, George, Quinn, Kevin P., Sauer, John-Michael, Wright, Sarah, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents von Sealy, Jennifer M., Truong, Anh P., Tso, Luke, Probst, Gary D., Aquino, Jose, Hom, Roy K., Jagodzinska, Barbara M., Dressen, Darren, Wone, David W.G., Brogley, Louis, John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Dappen, Michael S., Toth, Gergely, Pan, Hu, Ruslim, Lany, Miller, Jim, Bova, Michael P., Sinha, Sukanto, Quinn, Kevin P., Sauer, John-Michael

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Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration von Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Truong, Anh P., Hom, Roy K., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Quincy, David A., Pan, Hu, Yao, Nanhua, Lin, May, Tóth, Gergley, Artis, Dean R., Zmolek, Wes, Wong, Karina, Qin, Ann, Lorentzen, Colin, Nakamura, David F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Wright, Sarah, Chereau, David, Ren, Zhao, Anderson, John P., Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates von Bowers, Simeon, Xu, Ying-zi, Yuan, Shendong, Probst, Gary D., Hom, Roy K., Chan, Wayman, Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Pan, Hu, Brecht, Eric, Yao, Nanhua, Lougheed, Julie, Tam, Danny, Ren, Zhao, Ruslim, Lany, Bova, Michael P., Artis, Dean R.

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors von Ye, Xiaocong M., Konradi, Andrei W., Sun, Minghua, Yuan, Shendong, Aubele, Danielle L., Dappen, Michael, Dressen, Darren, Garofalo, Albert W., Jagodzinski, Jacek J., Latimer, Lee, Probst, Gary D., Sham, Hing L., Wone, David, Xu, Ying-zi, Ness, Daniel, Brigham, Elizabeth, Kwong, Grace T., Willtis, Chris, Tonn, George, Goldbach, Erich, Quinn, Kevin P., Zhang, Hongbin H., Sauer, John-Michael, Bova, Michael, Basi, Guriqbal S.

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Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors von Truong, Anh P., Aubele, Danielle L., Probst, Gary D., Neitzel, Martin L., Semko, Chris M., Bowers, Simeon, Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Garofalo, Albert W., Keim, Pamela S., Wu, Jing, Dappen, Michael S., Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Hemphill, Susanna S., Bova, Michael P., Basi, Guriqbal

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Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK von Hom, Roy K., Bowers, Simeon, Sealy, Jennifer M., Truong, Anh P., Probst, Gary D., Neitzel, Martin L., Neitz, R. Jeffrey, Fang, Larry, Brogley, Louis, Wu, Jing, Konradi, Andrei W., Sham, Hing L., Tóth, Gergely, Pan, Hu, Yao, Nanhua, Artis, Dean R., Quinn, Kevin, Sauer, John-Michael, Powell, Kyle, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene

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Ruthenium-Catalyzed Alder Ene Type Reactions. A Formal Synthesis of Alternaric Acid von Trost, Barry M, Probst, Gary D, Schoop, Andreas

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents von Truong, Anh P., Probst, Gary D., Aquino, Jose, Fang, Larry, Brogley, Louis, Sealy, Jennifer M., Hom, Roy K., Tucker, John A., John, Varghese, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Tóth, Gergley, Yao, Nanhua, Brecht, Eric, Pan, Hu, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region von Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Stupi, Brian, Dressen, Darren, Jagodzinska, Barbara M., Aquino, Jose, Gailunas, Andrea, Truong, Anh P., Tso, Luke, Xu, Ying-Zi, Hom, Roy K., John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Sham, Hing L., Jagodzinski, Jacek, Toth, Gergely, Brecht, Eric, Yao, Nanhua, Pan, Hu, Lin, May, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Gauby, Shawn, Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

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Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors von Aubele, Danielle L., Truong, Anh P., Dressen, Darren B., Probst, Gary D., Bowers, Simeon, Mattson, Matthew N., Semko, Chris M., Sun, Minghua, Garofalo, Albert W., Konradi, Andrei W., Sham, Hing L., Zmolek, Wes, Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Nguyen, Lan, Bova, Michael P., Hemphill, Susanna S., Basi, Guriqbal

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