The immune landscape of common CNS malignancies: implications for immunotherapy von Ott, Martina, Prins, Robert M., Heimberger, Amy B.

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Neoadjuvant PD-1 blockade induces T cell and cDC1 activation but fails to overcome the immunosuppressive tumor associated macrophages in recurrent glioblastoma von Lee, Alexander H., Sun, Lu, Mochizuki, Aaron Y., Reynoso, Jeremy G., Orpilla, Joey, Chow, Frances, Kienzler, Jenny C., Everson, Richard G., Nathanson, David A., Bensinger, Steven J., Liau, Linda M., Cloughesy, Timothy, Hugo, Willy, Prins, Robert M.

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2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling von Fu, Xudong, Chin, Randall M., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y., Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M., Teitell, Michael A., Nathanson, David A., Lai, Albert, Faull, Kym F., Jiang, Meisheng, Clarke, Steven G., Cloughesy, Timothy F., Graeber, Thomas G., Braas, Daniel, Christofk, Heather R., Jung, Michael E., Reue, Karen, Huang, Jing

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Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma von Cloughesy, Timothy F., Mochizuki, Aaron Y., Orpilla, Joey R., Hugo, Willy, Lee, Alexander H., Davidson, Tom B., Wang, Anthony C., Ellingson, Benjamin M., Rytlewski, Julie A., Sanders, Catherine M., Kawaguchi, Eric S., Du, Lin, Li, Gang, Yong, William H., Gaffey, Sarah C., Cohen, Adam L., Mellinghoff, Ingo K., Lee, Eudocia Q., Reardon, David A., O’Brien, Barbara J., Butowski, Nicholas A., Nghiemphu, Phioanh L., Clarke, Jennifer L., Arrillaga-Romany, Isabel C., Colman, Howard, Kaley, Thomas J., de Groot, John F., Liau, Linda M., Wen, Patrick Y., Prins, Robert M.

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Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients von Fong, Brendan, Jin, Richard, Wang, Xiaoyan, Safaee, Michael, Lisiero, Dominique N, Yang, Isaac, Li, Gang, Liau, Linda M, Prins, Robert M

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Bittinger, Mark A, Driggers, Edward M, Ward, Patrick S, Gross, Stefan, Su, Shinsan M, Liau, Linda M, Dang, Lenny, Fantin, Valeria R, Jang, Hyun Gyung, Marks, Kevin M, White, David W, Vander Heiden, Matthew G, Thompson, Craig B, Rabinowitz, Joshua D, Cantley, Lewis C, Keenan, Marie C, Prins, Robert M, Jin, Shengfang, Bennett, Bryson D, Yen, Katharine E

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Commentary on "Dysfunctional dendritic cells limit antigen-specific T cell response in glioma" von Prins, Robert M, Everson, Richard G

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TLR agonists polarize interferon responses in conjunction with dendritic cell vaccination in malignant glioma: a randomized phase II Trial von Everson, Richard G., Hugo, Willy, Sun, Lu, Antonios, Joseph, Lee, Alexander, Ding, Lizhong, Bu, Melissa, Khattab, Sara, Chavez, Carolina, Billingslea-Yoon, Emma, Salazar, Andres, Ellingson, Benjamin M., Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.

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Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy von PRINS, Robert M, SOTO, Horacio, KONKANKIT, Vera, ODESA, Sylvia K, ESKIN, Ascia, YONG, William H, NELSON, Stanley F, LIAU, Linda M

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Detection of immune responses after immunotherapy in glioblastoma using PET and MRI von Antonios, Joseph P., Soto, Horacio, Everson, Richard G., Moughon, Diana L., Wang, Anthony C., Orpilla, Joey, Radu, Caius, Ellingson, Benjamin M., Lee, Jason T., Cloughesy, Timothy, Phelps, Michael E., Czernin, Johannes, Liau, Linda M., Prins, Robert M.

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MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors von Kilian, Michael, Sheinin, Ron, Tan, Chin Leng, Friedrich, Mirco, Krämer, Christopher, Kaminitz, Ayelet, Sanghvi, Khwab, Lindner, Katharina, Chih, Yu-Chan, Cichon, Frederik, Richter, Benjamin, Jung, Stefanie, Jähne, Kristine, Ratliff, Miriam, Prins, Robert M., Etminan, Nima, von Deimling, Andreas, Wick, Wolfgang, Madi, Asaf, Bunse, Lukas, Platten, Michael

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Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma von Antonios, Joseph P, Soto, Horacio, Everson, Richard G, Moughon, Diana, Orpilla, Joey R, Shin, Namjo P, Sedighim, Shaina, Treger, Janet, Odesa, Sylvia, Tucker, Alexander, Yong, William H, Li, Gang, Cloughesy, Timothy F, Liau, Linda M, Prins, Robert M

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate von Marks, Kevin M, Rabinowitz, Joshua D, Dang, Lenny, Gross, Stefan, Fantin, Valeria R, Keenan, Marie C, Driggers, Edward M, Bennett, Bryson D, Jang, Hyun Gyung, Liau, Linda M, Ward, Patrick S, Jin, Shengfang, Yen, Katharine E, Su, Shinsan M, Prins, Robert M, Vander Heiden, Matthew G, White, David W, Cantley, Lewis C, Thompson, Craig B, Bittinger, Mark A

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pH-weighted molecular imaging of gliomas using amine chemical exchange saturation transfer MRI von Harris, Robert J, Cloughesy, Timothy F, Liau, Linda M, Prins, Robert M, Antonios, Joseph P, Li, Debiao, Yong, William H, Pope, Whitney B, Lai, Albert, Nghiemphu, Phioanh L, Ellingson, Benjamin M

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Immune checkpoint blockade induces distinct alterations in the microenvironments of primary and metastatic brain tumors von Sun, Lu, Kienzler, Jenny C, Reynoso, Jeremy G, Lee, Alexander, Shiuan, Eileen, Li, Shanpeng, Kim, Jiyoon, Ding, Lizhong, Monteleone, Amber J, Owens, Geoffrey C, Phillips, Joanna J, Everson, Richard G, Nathanson, David, Cloughesy, Timothy F, Li, Gang, Liau, Linda M, Hugo, Willy, Kim, Won, Prins, Robert M

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Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1 von Lu, Yue, Ng, Alphonsus H. C., Chow, Frances E., Everson, Richard G., Helmink, Beth A., Tetzlaff, Michael T., Thakur, Rohit, Wargo, Jennifer A., Cloughesy, Timothy F., Prins, Robert M., Heath, James R.

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Expression of PD-1 by T Cells in Malignant Glioma Patients Reflects Exhaustion and Activation von Davidson, Tom B, Lee, Alexander, Hsu, Melody, Sedighim, Shaina, Orpilla, Joey, Treger, Janet, Mastall, Max, Roesch, Saskia, Rapp, Carmen, Galvez, Mildred, Mochizuki, Aaron, Antonios, Joseph, Garcia, Alejandro, Kotecha, Nikesh, Bayless, Nicholas, Nathanson, David, Wang, Anthony, Everson, Richard, Yong, William H, Cloughesy, Timothy F, Liau, Linda M, Herold-Mende, Christel, Prins, Robert M

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Emerging immunotherapies for malignant glioma: from immunogenomics to cell therapy von Dunn, Gavin P, Cloughesy, Timothy F, Maus, Marcela V, Prins, Robert M, Reardon, David A, Sonabend, Adam M

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Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy von Pope, Whitney B., Prins, Robert M., Albert Thomas, M., Nagarajan, Rajakumar, Yen, Katharine E., Bittinger, Mark A., Salamon, Noriko, Chou, Arthur P., Yong, William H., Soto, Horacio, Wilson, Neil, Driggers, Edward, Jang, Hyun G., Su, Shinsan M., Schenkein, David P., Lai, Albert, Cloughesy, Timothy F., Kornblum, Harley I., Wu, Hong, Fantin, Valeria R., Liau, Linda M.

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Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma von Ladomersky, Erik, Zhai, Lijie, Lauing, Kristen L, Bell, April, Xu, Jiahui, Kocherginsky, Masha, Zhang, Bin, Wu, Jennifer D, Podojil, Joseph R, Platanias, Leonidas C, Mochizuki, Aaron Y, Prins, Robert M, Kumthekar, Priya, Raizer, Jeffrey J, Dixit, Karan, Lukas, Rimas V, Horbinski, Craig, Wei, Min, Zhou, Changyou, Pawelec, Graham, Campisi, Judith, Grohmann, Ursula, Prendergast, George C, Munn, David H, Wainwright, Derek A

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