Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression von Yu, Dongbo, Pendergraff, Hannah, Liu, Jing, Kordasiewicz, Holly B., Cleveland, Don W., Swayze, Eric E., Lima, Walt F., Crooke, Stanley T., Prakash, Thazha P., Corey, David R.

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An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics von Prakash, Thazha P.

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Overcoming the challenges of tissue delivery for oligonucleotide therapeutics von Gökirmak, Tufan, Nikan, Mehran, Wiechmann, Svenja, Prakash, Thazha P., Tanowitz, Michael, Seth, Punit P.

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Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes von Tanowitz, Michael, Hettrick, Lisa, Revenko, Alexey, Kinberger, Garth A, Prakash, Thazha P, Seth, Punit P

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Single-Stranded siRNAs Activate RNAi in Animals von Lima, Walt F., Prakash, Thazha P., Murray, Heather M., Kinberger, Garth A., Li, Wenyu, Chappell, Alfred E., Li, Cheryl S., Murray, Susan F., Gaus, Hans, Seth, Punit P., Swayze, Eric E., Crooke, Stanley T.

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Synthetic CRISPR RNA-Cas9–guided genome editing in human cells von Rahdar, Meghdad, McMahon, Moira A., Prakash, Thazha P., Swayze, Eric E., Bennett, C. Frank, Cleveland, Don W.

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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice von Prakash, Thazha P, Graham, Mark J, Yu, Jinghua, Carty, Rick, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Zhao, Chenguang, Aghajan, Mariam, Murray, Heather F, Riney, Stan, Booten, Sheri L, Murray, Susan F, Gaus, Hans, Crosby, Jeff, Lima, Walt F, Guo, Shuling, Monia, Brett P, Swayze, Eric E, Seth, Punit P

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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle von Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P

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Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs von Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P

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Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1 von Vickers, Timothy A, Rahdar, Meghdad, Prakash, Thazha P, Crooke, Stanley T

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Argonaute 2-dependent Regulation of Gene Expression by Single-stranded miRNA Mimics von Matsui, Masayuki, Prakash, Thazha P, Corey, David R

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Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice von Chappell, Alfred E, Gaus, Hans J, Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P, Oestergaard, Michael, Swayze, Eric E, Seth, Punit P

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Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells von McMahon, Moira A., Prakash, Thazha P., Cleveland, Don W., Bennett, C. Frank, Rahdar, Meghdad

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Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor von Schmidt, Karsten, Prakash, Thazha P, Donner, Aaron J, Kinberger, Garth A, Gaus, Hans J, Low, Audrey, Østergaard, Michael E, Bell, Melanie, Swayze, Eric E, Seth, Punit P

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Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell von Knerr, Laurent, Prakash, Thazha P, Lee, Richard, Drury III, William J, Nikan, Mehran, Fu, Wuxia, Pirie, Elaine, Maria, Leonardo De, Valeur, Eric, Hayen, Ahlke, Ölwegård-Halvarsson, Maria, Broddefalk, Johan, Ämmälä, Carina, Østergaard, Michael E, Meuller, Johan, Sundström, Linda, Andersson, Patrik, Janzén, David, Jansson-Löfmark, Rasmus, Seth, Punit P, Andersson, Shalini

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Premature transcription termination at the expanded GAA repeats and aberrant alternative polyadenylation contributes to the Frataxin transcriptional deficit in Friedreich's ataxia von Li, Yanjie, Li, Jixue, Wang, Jun, Zhang, Siyuan, Giles, Keith, Prakash, Thazha P, Rigo, Frank, Napierala, Jill S, Napierala, Marek

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Structural Analysis of Human Argonaute‑2 Bound to a Modified siRNA Guide von Schirle, Nicole T, Kinberger, Garth A, Murray, Heather F, Lima, Walt F, Prakash, Thazha P, MacRae, Ian J

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Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models von Kim, Youngsoo, Jo, Minji, Schmidt, Joanna, Luo, Xiaolin, Prakash, Thazha P., Zhou, Tianyuan, Klein, Stephanie, Xiao, Xiaokun, Post, Noah, Yin, Zhengfeng, MacLeod, A. Robert

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Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells von Wang, Shiyu, Allen, Nickolas, Prakash, Thazha P., Liang, Xue-hai, Crooke, Stanley T.

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TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells von Liang, Xue-hai, Shen, Wen, Sun, Hong, Prakash, Thazha P, Crooke, Stanley T

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