An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics von Prakash, Thazha P.

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Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression von Yu, Dongbo, Pendergraff, Hannah, Liu, Jing, Kordasiewicz, Holly B., Cleveland, Don W., Swayze, Eric E., Lima, Walt F., Crooke, Stanley T., Prakash, Thazha P., Corey, David R.

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Overcoming the challenges of tissue delivery for oligonucleotide therapeutics von Gökirmak, Tufan, Nikan, Mehran, Wiechmann, Svenja, Prakash, Thazha P., Tanowitz, Michael, Seth, Punit P.

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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice von Prakash, Thazha P, Graham, Mark J, Yu, Jinghua, Carty, Rick, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Zhao, Chenguang, Aghajan, Mariam, Murray, Heather F, Riney, Stan, Booten, Sheri L, Murray, Susan F, Gaus, Hans, Crosby, Jeff, Lima, Walt F, Guo, Shuling, Monia, Brett P, Swayze, Eric E, Seth, Punit P

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Synthetic CRISPR RNA-Cas9–guided genome editing in human cells von Rahdar, Meghdad, McMahon, Moira A., Prakash, Thazha P., Swayze, Eric E., Bennett, C. Frank, Cleveland, Don W.

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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle von Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P

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Single-Stranded siRNAs Activate RNAi in Animals von Lima, Walt F., Prakash, Thazha P., Murray, Heather M., Kinberger, Garth A., Li, Wenyu, Chappell, Alfred E., Li, Cheryl S., Murray, Susan F., Gaus, Hans, Seth, Punit P., Swayze, Eric E., Crooke, Stanley T.

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Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs von Vasquez, Guillermo, Freestone, Graeme C, Wan, W Brad, Low, Audrey, De Hoyos, Cheryl Li, Yu, Jinghua, Prakash, Thazha P, Ǿstergaard, Michael E, Liang, Xue-hai, Crooke, Stanley T, Swayze, Eric E, Migawa, Michael T, Seth, Punit P

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Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1 von Vickers, Timothy A, Rahdar, Meghdad, Prakash, Thazha P, Crooke, Stanley T

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Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice von Chappell, Alfred E., Gaus, Hans J., Berdeja, Andres, Gupta, Ruchi, Jo, Minji, Prakash, Thazha P., Oestergaard, Michael, Swayze, Eric E., Seth, Punit P.

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Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor von Schmidt, Karsten, Prakash, Thazha P, Donner, Aaron J, Kinberger, Garth A, Gaus, Hans J, Low, Audrey, Østergaard, Michael E, Bell, Melanie, Swayze, Eric E, Seth, Punit P

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Structural Analysis of Human Argonaute‑2 Bound to a Modified siRNA Guide von Schirle, Nicole T, Kinberger, Garth A, Murray, Heather F, Lima, Walt F, Prakash, Thazha P, MacRae, Ian J

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Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell von Knerr, Laurent, Prakash, Thazha P, Lee, Richard, Drury III, William J, Nikan, Mehran, Fu, Wuxia, Pirie, Elaine, Maria, Leonardo De, Valeur, Eric, Hayen, Ahlke, Ölwegård-Halvarsson, Maria, Broddefalk, Johan, Ämmälä, Carina, Østergaard, Michael E, Meuller, Johan, Sundström, Linda, Andersson, Patrik, Janzén, David, Jansson-Löfmark, Rasmus, Seth, Punit P, Andersson, Shalini

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Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes von Prakash, Thazha P, Yu, Jinghua, Migawa, Michael T, Kinberger, Garth A, Wan, W. Brad, Østergaard, Michael E, Carty, Recaldo L, Vasquez, Guillermo, Low, Audrey, Chappell, Alfred, Schmidt, Karsten, Aghajan, Mariam, Crosby, Jeff, Murray, Heather M, Booten, Sheri L, Hsiao, Jill, Soriano, Armand, Machemer, Todd, Cauntay, Patrick, Burel, Sebastien A, Murray, Susan F, Gaus, Hans, Graham, Mark J, Swayze, Eric E, Seth, Punit P

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Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver von Miller, Colton M., Tanowitz, Michael, Donner, Aaron J., Prakash, Thazha P., Swayze, Eric E., Harris, Edward N., Seth, Punit P.

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Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides von Østergaard, Michael E, Yu, Jinghua, Kinberger, Garth A, Wan, W. Brad, Migawa, Michael T, Vasquez, Guillermo, Schmidt, Karsten, Gaus, Hans J, Murray, Heather M, Low, Audrey, Swayze, Eric E, Prakash, Thazha P, Seth, Punit P

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Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing von Rigo, Frank, Hua, Yimin, Chun, Seung J, Prakash, Thazha P, Krainer, Adrian R, Bennett, C Frank

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Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs von Hu, Jiaxin, Rigo, Frank, Prakash, Thazha P., Corey, David R.

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Synergistic effect of phosphorothioate, 5′-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA von Prakash, Thazha P., Kinberger, Garth A., Murray, Heather M., Chappell, Alfred, Riney, Stan, Graham, Mark J., Lima, Walt F., Swayze, Eric E., Seth, Punit P.

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Site-specific Incorporation of 2′,5′-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides von Prakash, Thazha P, Yu, Jinghua, Shen, Wen, De Hoyos, Cheryl Li, Berdeja, Andres, Gaus, Hans, Liang, Xue-hai, Crooke, Stanley T, Seth, Punit P

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