Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery von Merk, Alan, Bartesaghi, Alberto, Banerjee, Soojay, Falconieri, Veronica, Rao, Prashant, Davis, Mindy I., Pragani, Rajan, Boxer, Matthew B., Earl, Lesley A., Milne, Jacqueline L.S., Subramaniam, Sriram

Volltext

FDA Approval Summary: Lurbinectedin for the Treatment of Metastatic Small Cell Lung Cancer von Singh, Sonia, Jaigirdar, Adnan A., Mulkey, Flora, Cheng, Joyce, Hamed, Salaheldin S., Li, Yangbing, Liu, Jiang, Zhao, Hong, Goheer, Anwar, Helms, Whitney S., Wang, Xing, Agarwal, Rajiv, Pragani, Rajan, Korsah, Kwadwo, Tang, Shenghui, Leighton, John, Rahman, Atiqur, Beaver, Julia A., Pazdur, Richard, Theoret, Marc R., Singh, Harpreet

Volltext

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Mod... von Davis, Mindy I., Pragani, Rajan, Fox, Jennifer T., Shen, Min, Parmar, Kalindi, Gaudiano, Emily F., Liu, Li, Tanega, Cordelle, McGee, Lauren, Hall, Matthew D., McKnight, Crystal, Shinn, Paul, Nelson, Henrike, Chattopadhyay, Debasish, D'Andrea, Alan D., Auld, Douglas S., DeLucas, Larry J., Li, Zhuyin, Boxer, Matthew B., Simeonov, Anton

Volltext

Total Synthesis of the Bacteroides fragilis Zwitterionic Polysaccharide A1 Repeating Unit von Pragani, Rajan, Seeberger, Peter H

Volltext

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays von Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.

Volltext

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1 von Davis, Mindy I., Gross, Stefan, Shen, Min, Straley, Kimberly S., Pragani, Rajan, Lea, Wendy A., Popovici-Muller, Janeta, DeLaBarre, Byron, Artin, Erin, Thorne, Natasha, Auld, Douglas S., Li, Zhuyin, Dang, Lenny, Boxer, Matthew B., Simeonov, Anton

Volltext

De Novo Synthesis of a 2-Acetamido-4-amino-2,4,6-trideoxy-d-galactose (AAT) Building Block for the Preparation of a Bacteroides fragilis A1 Polysaccharide Fragment von Pragani, Rajan, Stallforth, Pierre, Seeberger, Peter H

Volltext

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation von Davis, Mindy I, Sasaki, Atsuo T, Shen, Min, Emerling, Brooke M, Thorne, Natasha, Michael, Sam, Pragani, Rajan, Boxer, Matthew, Sumita, Kazutaka, Takeuchi, Koh, Auld, Douglas S, Li, Zhuyin, Cantley, Lewis C, Simeonov, Anton

Volltext

FDA Approval Summary: Mirvetuximab Soravtansine-Gynx for FRα-Positive, Platinum-Resistant Ovarian Cancer von Dilawari, Asma, Shah, Mirat, Ison, Gwynn, Gittleman, Haley, Fiero, Mallorie H, Shah, Ankit, Hamed, Salaheldin S, Qiu, Junshan, Yu, Jingyu, Manheng, Wimolnut, Ricks, Tiffany K, Pragani, Rajan, Arudchandran, Arulvathani, Patel, Paresma, Zaman, Shadia, Roy, Arpita, Kalavar, Shyam, Ghosh, Soma, Pierce, William F, Rahman, Nam Atiqur, Tang, Shenghui, Mixter, Bronwyn D, Kluetz, Paul G, Pazdur, Richard, Amiri-Kordestani, Laleh

Volltext

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion von Kofuji, Satoshi, Wolfe, Kara, Sumita, Kazutaka, Kageyama, Shun, Yoshino, Hirofumi, Hirota, Yoshihisa, Ogawa-Iio, Aki, Kanoh, Hirotaka, Sasaki, Mika, Kofuji, Kaori, Davis, Mindy I., Pragani, Rajan, Shen, Min, Boxer, Matthew B., Nakatsu, Fubito, Nigorikawa, Kiyomi, Sasaki, Takehiko, Takeuchi, Koh, Senda, Toshiya, Kim, Seong M., Edinger, Aimee L., Simeonov, Anton, Sasaki, Atsuo T.

Volltext

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells von Ikeda, Yoshiki, Davis, Mindy I., Sumita, Kazutaka, Zheng, Yuxiang, Kofuji, Satoshi, Sasaki, Mika, Hirota, Yoshihisa, Pragani, Rajan, Shen, Min, Boxer, Matthew B., Takeuchi, Koh, Senda, Toshiya, Simeonov, Anton, Sasaki, Atsuo T.

Volltext

De Novo Synthesis of l-Colitose and l-Rhodinose Building Blocks von Calin, Oliviana, Pragani, Rajan, Seeberger, Peter H

Volltext

Discovery and Optimization of 2H‑1λ2‑Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer von Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B

Volltext

Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors von Liu, Li, Tang, Manshu, Pragani, Rajan, Whitby, Frank G, Zhang, Ya-qin, Balakrishnan, Bijina, Fang, Yuhong, Karavadhi, Surendra, Tao, Dingyin, LeClair, Christopher A, Hall, Matthew D, Marugan, Juan J, Boxer, Matthew, Shen, Min, Hill, Christopher P, Lai, Kent, Patnaik, Samarjit

Volltext

Discovery and Optimization of 2 H -1λ 2 -Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer von Rohde, Jason M, Karavadhi, Surendra, Pragani, Rajan, Liu, Li, Fang, Yuhong, Zhang, Weihe, McIver, Andrew, Zheng, Hongchao, Liu, Qingyang, Davis, Mindy I, Urban, Daniel J, Lee, Tobie D, Cheff, Dorian M, Hollingshead, Melinda, Henderson, Mark J, Martinez, Natalia J, Brimacombe, Kyle R, Yasgar, Adam, Zhao, Wei, Klumpp-Thomas, Carleen, Michael, Sam, Covey, Joseph, Moore, William J, Stott, Gordon M, Li, Zhuyin, Simeonov, Anton, Jadhav, Ajit, Frye, Stephen, Hall, Matthew D, Shen, Min, Wang, Xiaodong, Patnaik, Samarjit, Boxer, Matthew B

Volltext

Abstract 4714: Targeting p53 mutant cancers through inhibition of the phosphatidylinositol-5-phosphate 4-kinases von Emerling, Brooke M., Yang, Zhiwei, Loughran, Ryan, Yang, T.Jonathan, Johnson, Jared, Pragani, Rajan, Davis, Mindy, Shen, Min, Boxer, Matthew, Simeonov, Anton, Cantley, Lewis C.

Volltext

Structure activity relationships of human galactokinase inhibitors von Liu, Li, Tang, Manshu, Walsh, Martin J., Brimacombe, Kyle R., Pragani, Rajan, Tanega, Cordelle, Rohde, Jason M., Baker, Heather L., Fernandez, Elizabeth, Blackman, Burchelle, Bougie, James M., Leister, William H., Auld, Douglas S., Shen, Min, Lai, Kent, Boxer, Matthew B.

Volltext

Studies on the Synthesis of Durhamycin A: Stereoselective Synthesis of a Model Aglycone von Pragani, Rajan, Roush, William R

Volltext

CS-33DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME von Sumita, Kazutaka, Davis, Mindy, Pragani, Rajan, Terakawa, Jumpei, Daikoku, Takiko, Majd, Nazanin, Shen, Min, Li, Zhuyin, Hu, Xin, Cantley, Lewis, Boxer, Matthew, Simeonov, Anton, Sasaki, Atsuo

Volltext

CS-33 DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME von Sumita, K., Davis, M., Pragani, R., Terakawa, J., Daikoku, T., Majd, N., Shen, M., Li, Z., Hu, X., Cantley, L., Boxer, M., Simeonov, A., Sasaki, A.

Volltext