The promise of patient-derived xenografts: the best laid plans of mice and men von Kopetz, Scott, Lemos, Robert, Powis, Garth

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Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling von Kirkpatrick, D Lynn, Powis, Garth

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Thioredoxin signaling as a target for cancer therapy von Powis, Garth, Kirkpatrick, D Lynn

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Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy von Ihle, Nathan T, Powis, Garth

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Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation von Koh, Mei Yee, Darnay, Bryant G., Powis, Garth

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Modeling of Patient-Derived Xenografts in Colorectal Cancer von Katsiampoura, Anastasia, Raghav, Kanwal, Jiang, Zhi-Qin, Menter, David G, Varkaris, Andreas, Morelli, Maria P, Manuel, Shanequa, Wu, Ji, Sorokin, Alexey V, Rizi, Bahar Salimian, Bristow, Christopher, Tian, Feng, Airhart, Susan, Cheng, Mingshan, Broom, Bradley M, Morris, Jeffrey, Overman, Michael J, Powis, Garth, Kopetz, Scott

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ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation von de Jong, Petrus R., Taniguchi, Koji, Harris, Alexandra R., Bertin, Samuel, Takahashi, Naoki, Duong, Jen, Campos, Alejandro D., Powis, Garth, Corr, Maripat, Karin, Michael, Raz, Eyal

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Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome von Ihle, Nathan T., Byers, Lauren A., Kim, Edward S., Saintigny, Pierre, Lee, J. Jack, Blumenschein, George R., Tsao, Anne, Liu, Suyu, Larsen, Jill E., Wang, Jing, Diao, Lixia, Coombes, Kevin R., Chen, Lu, Zhang, Shuxing, Abdelmelek, Mena F., Tang, Ximing, Papadimitrakopoulou, Vassiliki, Minna, John D., Lippman, Scott M., Hong, Waun K., Herbst, Roy S., Wistuba, Ignacio I., Heymach, John V., Powis, Garth

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Hypoxia Triggers Hedgehog-Mediated Tumor―Stromal Interactions in Pancreatic Cancer von SPIVAK-KROIZMAN, Taly R, HOSTETTER, Galen, KIRIAKOVA, Galina M, ABDELMELEK, Mena, BARTHOLOMEUSZ, Geoffrey, JAMES, Brian P, POWIS, Garth, POSNER, Richard, AZIZ, Meraj, CHENGCHENG HU, DEMEURE, Michael J, VON HOFF, Daniel, HINGORANI, Sunil R, PALCULICT, Timothy B, IZZO, Julie

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Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance von IHLE, Nathan T, LEMOS, Robert, WIPF, Peter, YACOUB, Adly, MITCHELL, Clint, SIWAK, Doris, MILLS, Gordon B, DENT, Paul, KIRKPATRICK, D. Lynn, POWIS, Garth

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Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1α von Mei Y. Koh, Taly Spivak-Kroizman, Sara Venturini, Sarah Welsh, Ryan R. Williams, D. Lynn Kirkpatrick, Garth Powis

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Passing the baton: the HIF switch von Koh, Mei Yee, Powis, Garth

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The role of the redox protein thioredoxin in cell growth and cancer von Powis, Garth, Mustacich, Debbie, Coon, Amy

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An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors von Indarte, Martin, Puentes, Roisin, Maruggi, Marco, Ihle, Nathan T, Grandjean, Geoffrey, Scott, Michael, Ahmed, Zamal, Meuillet, Emmanuelle J, Zang, Shuxing, Lemos, Jr, Robert, Du-Cuny, Lei, Layng, Fabiana I A L, Correa, Ricardo G, Bankston, Laurie A, Liddington, Robert C, Kirkpatrick, Lynn, Powis, Garth

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Properties and biological activities of thioredoxins von Powis, G, Montfort, W R

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Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma von Koh, Mei Yee, Nguyen, Vuvi, Lemos, Jr, Robert, Darnay, Bryant G, Kiriakova, Galina, Abdelmelek, Mena, Ho, Thai H, Karam, Jose, Monzon, Federico A, Jonasch, Eric, Powis, Garth

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The Absence of Mitochondrial Thioredoxin 2 Causes Massive Apoptosis, Exencephaly, and Early Embryonic Lethality in Homozygous Mice von Nonn, Larisa, Williams, Ryan R., Erickson, Robert P., Powis, Garth

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The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression von Kim, Jeong Min, Jeung, Hei-Cheul, Rha, Sun Young, Yu, Eun Jeong, Kim, Tae Soo, Shin, You Keun, Zhang, Xianglan, Park, Kyu Hyun, Park, Seung Woo, Chung, Hyun Cheol, Powis, Garth

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Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activ... von Meuillet, Emmanuelle J, Mahadevan, Daruka, Berggren, Margareta, Coon, Amy, Powis, Garth

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Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling von Ihle, Nathan T, Williams, Ryan, Chow, Sherry, Chew, Wade, Berggren, Margareta I, Paine-Murrieta, Gillian, Minion, Daniel J, Halter, Robert J, Wipf, Peter, Abraham, Robert, Kirkpatrick, Lynn, Powis, Garth

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