Peripheral immune-based biomarkers in cancer immunotherapy: can we realize their predictive potential? von Nixon, Andrew B., Schalper, Kurt A., Jacobs, Ira, Potluri, Shobha, Wang, I-Ming, Fleener, Catherine

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Engineering potent chimeric antigen receptor T cells by programming signaling during T-cell activation von Li, Aileen W., Briones, Jessica D., Lu, Jia, Walker, Quinn, Martinez, Rowena, Hiraragi, Hajime, Boldajipour, Bijan A., Sundar, Purnima, Potluri, Shobha, Lee, Gary, Ali, Omar A., Cheung, Alexander S.

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Intra-Tumoral Activation of Endosomal TLR Pathways Reveals a Distinct Role for TLR3 Agonist Dependent Type-1 Interferons in Shaping the Tumor Immune Microenvironment von Thomas, Graham, Micci, Luca, Yang, Wenjing, Katakowski, Joseph, Oderup, Cecilia, Sundar, Purnima, Wang, Xiao, Geles, Kenneth G., Potluri, Shobha, Salek-Ardakani, Shahram

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393 Rejuvenation of tumor-infiltrating lymphocytes (TIL) through partial reprogramming von Maeda, Takuya, Huang, Yin, Fioravanti, Jessica, Tamaoki, Naritaka, Kutlu, Burak, Yamazaki, Yasuhiro, Bahl, Kriti, Wang, Biao, Zhong, Zheng, Potluri, Shobha, Lee, Gary, Restifo, Nicholas, Vizcardo, Raul

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379 Epi-RTM P2 protocol produces a scalable polyclonal TIL product with a greater expansion success rate across hot and cold tumors in shorter culture time von Patel, Yogin, Yun, Jaewon, Bedard, Melissa, DeFrancesco, Melissa, Harms, Carson, Harris, Benjamin, Azimi, Saeed, Ha, Ngoc-Han, Garces, Audrey, Potluri, Shobha, Lee, Gary, Vodnala, Suman

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278 Preclinical development of LYL119, a ROR1-targeted CAR T-cell product incorporating four novel T-cell reprogramming technologies to overcome barriers to effective cell therapy... von Lam, Viola C, Li, Aileen, Casas, Meritxell Galindo, Barragan, Jessica, Cheung, Christina, Briones, Jessica, Afreen, Esha, Vavra, Grant, Lu, Jia, Sundar, Purnima, Martinez, Rowena, Sims, Candace, Ta, Christina, Nigatu, Eskedar, Potluri, Shobha, Ali, Omar, Cheung, Alexander S, Lynn, Rachel C

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Effect of genome and environment on metabolic and inflammatory profiles von Sirota, Marina, Willemsen, Gonneke, Sundar, Purnima, Pitts, Steven J, Potluri, Shobha, Prifti, Edi, Kennedy, Sean, Ehrlich, S Dusko, Neuteboom, Jacoline, Kluft, Cornelis, Malone, Karen E, Cox, David R, de Geus, Eco J C, Boomsma, Dorret I

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PFAAT version 2.0: a tool for editing, annotating, and analyzing multiple sequence alignments von Caffrey, Daniel R, Dana, Paul H, Mathur, Vidhya, Ocano, Marco, Hong, Eun-Jong, Wang, Yaoyu E, Somaroo, Shyamal, Caffrey, Brian E, Potluri, Shobha, Huang, Enoch S

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Aging as Accelerated Accumulation of Somatic Variants: Whole-Genome Sequencing of Centenarian and Middle-Aged Monozygotic Twin Pairs von Ye, Kai, Beekman, Marian, Lameijer, Eric-Wubbo, Zhang, Yanju, Moed, Matthijs H., van den Akker, Erik B., Deelen, Joris, Houwing-Duistermaat, Jeanine J., Kremer, Dennis, Anvar, Seyed Yahya, Laros, Jeroen F. J., Jones, David, Raine, Keiran, Blackburne, Ben, Potluri, Shobha, Long, Quan, Guryev, Victor, van der Breggen, Ruud, Westendorp, Rudi G. J., ‘t Hoen, Peter A. C., den Dunnen, Johan, van Ommen, Gert Jan B., Willemsen, Gonneke, Pitts, Steven J., Cox, David R., Ning, Zemin, Boomsma, Dorret I., Slagboom, P. Eline

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Baseline Frequency of Inflammatory Cxcl9-Expressing Tumor-Associated Macrophages Predicts Response to Avelumab Treatment von Qu, Yan, Wen, Ji, Thomas, Graham, Yang, Wenjing, Prior, Weiwei, He, Wenqian, Sundar, Purnima, Wang, Xiao, Potluri, Shobha, Salek-Ardakani, Shahram

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Whole-genome sequence variation, population structure and demographic history of the Dutch population von Francioli, Laurent C, Menelaou, Androniki, Pulit, Sara L, van Dijk, Feerk, Palamara, Pier Francesco, Elbers, Clara C, Neerincx, Pieter B T, Ye, Kai, Guryev, Victor, Kloosterman, Wigard P, Deelen, Patrick, Abdellaoui, Abdel, van Leeuwen, Elisabeth M, van Oven, Mannis, Vermaat, Martijn, Li, Mingkun, Laros, Jeroen F J, Karssen, Lennart C, Kanterakis, Alexandros, Amin, Najaf, Hottenga, Jouke Jan, Lameijer, Eric-Wubbo, Kattenberg, Mathijs, Dijkstra, Martijn, Byelas, Heorhiy, van Setten, Jessica, van Schaik, Barbera D C, Bot, Jan, Nijman, Isaäc J, Renkens, Ivo, Marschall, Tobias, Schönhuth, Alexander, Hehir-Kwa, Jayne Y, Handsaker, Robert E, Polak, Paz, Sohail, Mashaal, Vuzman, Dana, Hormozdiari, Fereydoun, van Enckevort, David, Mei, Hailiang, Koval, Vyacheslav, Moed, Matthijs H, van der Velde, K Joeri, Rivadeneira, Fernando, Estrada, Karol, Medina-Gomez, Carolina, Isaacs, Aaron, McCarroll, Steven A, Beekman, Marian, de Craen, Anton J M, Suchiman, H Eka D, Hofman, Albert, Oostra, Ben, Uitterlinden, André G, Willemsen, Gonneke, Platteel, Mathieu, Veldink, Jan H, van den Berg, Leonard H, Pitts, Steven J, Potluri, Shobha, Sundar, Purnima, Cox, David R, Sunyaev, Shamil R, den Dunnen, Johan T, Stoneking, Mark, de Knijff, Peter, Kayser, Manfred, Li, Qibin, Li, Yingrui, Du, Yuanping, Chen, Ruoyan, Cao, Hongzhi, Li, Ning, Cao, Sujie, Wang, Jun, Bovenberg, Jasper A, Pe'er, Itsik, Slagboom, P Eline, van Duijn, Cornelia M, Boomsma, Dorret I, van Ommen, Gert-Jan B, de Bakker, Paul I W, Swertz, Morris A, Wijmenga, Cisca

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Baseline Frequency of Inflammatory Cxcl9-Expressing Tumor-Associated Macrophages Predicts Response to Avelumab Treatment von Qu, Yan, Wen, Ji, Thomas, Graham, Yang, Wenjing, Prior, Weiwei, He, Wenqian, Sundar, Purnima, Wang, Xiao, Potluri, Shobha, Salek-Ardakani, Shahram

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Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia von Malik, Manasi, Chiles, 3rd, Joe, Xi, Hualin S, Medway, Christopher, Simpson, James, Potluri, Shobha, Howard, Dianna, Liang, Ying, Paumi, Christian M, Mukherjee, Shubhabrata, Crane, Paul, Younkin, Steven, Fardo, David W, Estus, Steven

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ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection von Metzger, Todd C, Long, Hua, Potluri, Shobha, Pertel, Thomas, Bailey-Bucktrout, Samantha L, Lin, John C, Fu, Tihui, Sharma, Padmanee, Allison, James P, Feldman, Reid M R

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Abstract A041: Rejuvenation: Innovative technology to improve T-cell antitumor properties through partial reprogramming von Fioravanti, Jessica, Yamazaki, Yasuhiro, Maeda, Takuya, Huang, Yin, Tamaoki, Naritaka, Bahl, Kriti, Kutlu, Burak, Potluri, Shobha, Lee, Gary, Restifo, Nicholas P, Vizcardo, Raul

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Abstract CT046: Predictive biomarkers and pharmacodynamic changes in tumor RNA expression in a phase I study of anti PD-1 monoclonal antibody PF-06801591 von Hu-Lieskovan, Siwen, Braiteh, Fadi, Grilley-Olson, Juneko E., Potluri, Shobha, Wang, Xiao, Forgie, Alison, Bonato, Vinicius, Chou, Jeffrey, Johnson, Melissa L.

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Negative selection in humans and fruit flies involves synergistic epistasis von Sohail, Mashaal, Vakhrusheva, Olga A., Sul, Jae Hoon, Pulit, Sara L., Francioli, Laurent C., van den Berg, Leonard H., Veldink, Jan H., de Bakker, Paul I. W., Bazykin, Georgii A., Kondrashov, Alexey S., Sunyaev, Shamil R.

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Population-specific genotype imputations using minimac or IMPUTE2 von van Leeuwen, Elisabeth M, Kanterakis, Alexandros, Deelen, Patrick, Kattenberg, Mathijs V, Slagboom, P Eline, de Bakker, Paul I W, Wijmenga, Cisca, Swertz, Morris A, Boomsma, Dorret I, van Duijn, Cornelia M, Karssen, Lennart C, Hottenga, Jouke Jan

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Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands' von Deelen, Patrick, Menelaou, Androniki, van Leeuwen, Elisabeth M, Kanterakis, Alexandros, van Dijk, Freerk, Medina-Gomez, Carolina, Francioli, Laurent C, Hottenga, Jouke Jan, Karssen, Lennart C, Estrada, Karol, Kreiner-Møller, Eskil, Rivadeneira, Fernando, van Setten, Jessica, Gutierrez-Achury, Javier, Westra, Harm-Jan, Franke, Lude, van Enckevort, David, Dijkstra, Martijn, Byelas, Heorhiy, van Duijn, Cornelia M, de Bakker, Paul I W, Wijmenga, Cisca, Swertz, Morris A

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Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates von Palamara, Pier Francesco, Francioli, Laurent C., Wilton, Peter R., Genovese, Giulio, Gusev, Alexander, Finucane, Hilary K., Sankararaman, Sriram, Sunyaev, Shamil R., de Bakker, Paul I.W., Wakeley, John, Pe’er, Itsik, Price, Alkes L.

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