Discovery of 2‑[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro‑1H‑isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP‑1... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

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Synthesis and SAR of new pyrazolo[4,3- h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors von Caldarelli, Marina, Angiolini, Mauro, Disingrini, Teresa, Donati, Daniele, Guanci, Marco, Nuvoloni, Stefano, Posteri, Helena, Quartieri, Francesca, Silvagni, Marco, Colombo, Riccardo

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Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors von Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

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A New Glycociamidine Ring Precursor:  Syntheses of (Z)-Hymenialdisine, (Z)-2-Debromohymenialdisine, and (±)-endo-2-Debromohymenialdisine von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Varasi, Mario

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Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity? von Papeo, Gianluca, Forte, Barbara, Orsini, Paolo, Perrera, Claudia, Posteri, Helena, Scolaro, Alessandra, Montagnoli, Alessia

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Discovery of Stereospecific PARP‑1 Inhibitor Isoindolinone NMS-P515 von Papeo, Gianluca, Orsini, Paolo, Avanzi, Nilla R, Borghi, Daniela, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Desperati, Viviana, Donati, Daniele, Felder, Eduard R, Galvani, Arturo, Guanci, Marco, Isacchi, Antonella, Posteri, Helena, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Montagnoli, Alessia

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NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor von Beria, Italo, Bossi, Roberto T, Brasca, Maria Gabriella, Caruso, Michele, Ceccarelli, Walter, Fachin, Gabriele, Fasolini, Marina, Forte, Barbara, Fiorentini, Francesco, Pesenti, Enrico, Pezzetta, Daniele, Posteri, Helena, Scolaro, Alessandra, Depaolini, Stefania Re, Valsasina, Barbara

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Identification of 4,5-Dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors von Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

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Abstract 3795: Novel and selective MELK kinase inhibitors active in breast cancer cell lines von Carpinelli, Patrizia, Montemartini, Marisa, Amboldi, Nadia, Ballinari, Dario, Cribioli, Sabrina, Ciomei, Marina, Colombo, Riccardo, Re Depaolini, Stefania, Avanzi, Nilla, Canevari, Giulia, Ceccarelli, Walter, Posteri, Helena, Brasca, Maria Gabriella, Donati, Daniele, Felder, Eduard Rudolf, Isacchi, Antonella, Galvani, Arturo, Montagnoli, Alessia

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Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1 H -isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

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Stereoselective synthesis of ( Z)-axino- and ( Z)-debromoaxinohydantoin von Tutino, Federico, Posteri, Helena, Borghi, Daniela, Quartieri, Francesca, Mongelli, Nicola, Papeo, Gianluca

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4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors von Beria, Italo, Valsasina, Barbara, Brasca, Maria Gabriella, Ceccarelli, Walter, Colombo, Maristella, Cribioli, Sabrina, Fachin, Gabriele, Ferguson, Ronald D., Fiorentini, Francesco, Gianellini, Laura M., Giorgini, Maria L., Moll, Jurgen K., Posteri, Helena, Pezzetta, Daniele, Roletto, Fulvia, Sola, Francesco, Tesei, Dania, Caruso, Michele

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Abstract 1775: Characterization of new highly selective and potent PARP-1 inhibitors von Montagnoli, Alessia, Papeo, Gianluca, Rainoldi, Sonia, Ciavolella, Antonella, Sola, Francesco, Lupi, Rosita, Ciomei, Marina, Cirla, Alessandra, Scolaro, Alessandra, Posteri, Helena, Donati, Daniele, Felder, Eduard, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo

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Nicotinoyl Azide (NCA)-Mediated Mitsunobu Reaction: An Expedient One-Pot Transformation of Alcohols into Azides von Papeo, Gianluca, Posteri, Helena, Vianello, Paola, Varasi, Mario

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NMS-P937, a 4,5-dihydro-1 H-pyrazolo[4,3- h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor von Beria, Italo, Bossi, Roberto T., Brasca, Maria Gabriella, Caruso, Michele, Ceccarelli, Walter, Fachin, Gabriele, Fasolini, Marina, Forte, Barbara, Fiorentini, Francesco, Pesenti, Enrico, Pezzetta, Daniele, Posteri, Helena, Scolaro, Alessandra, Depaolini, Stefania Re, Valsasina, Barbara

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Abstract 691: In vitro and in vivo characterization of selective orally available Parp-1 inhibitors with demonstrated antitumor efficacy in BRCA negative cancer models von Papeo, Gianluca, Rainoldi, Sonia, Gianellini, Laura, Ciavolella, Antonella, Leone, Antonella, Lupi, Rosita, Sola, Francesco, Caprera, Francesco, Paolucci, Mauro, Thieffine, Sandrine, Perego, Rita, Albanese, Clara, Casale, Elena, Forte, Barbara, Guanci, Marco, Orsini, Paolo, Posteri, Helena, Scolaro, Alessandra, Riccardi-Sirtori, Federico, Zuccotto, Fabio, Donati, Daniele, Moll, Jurgen, Montagnoli, Alessia

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Synthesis, Conformational Studies and Mannosidase Stability of a Mimic of 1,2-Mannobioside von Mari, Silvia, Posteri, Helena, Marcou, Gilles, Potenza, Donatella, Micheli, Fabrizio, Cañada, F. Javier, Jimenez-Barbero, Jesus, Bernardi, Anna

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Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue von Bernardi, Anna, Arosio, Daniela, Manzoni, Leonardo, Monti, Diego, Posteri, Helena, Potenza, Donatella, Mari, Silvia, Jiménez-Barbero, Jesús

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SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS von BUFFA, Laura, MIRIZZI, Danilo, MENICHINCHERI, Maria, POSTERI, Helena, MOTTO, Ilaria

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SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS von BUFFA, Laura, MIRIZZI, Danilo, MENICHINCHERI, Maria, POSTERI, Helena, MOTTO, Ilaria

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