Receptor Occupancy and Brain Free Fraction von Watson, Jeanette, Wright, Sara, Lucas, Adam, Clarke, Kirsten L., Viggers, Jean, Cheetham, Sharon, Jeffrey, Phil, Porter, Rod, Read, Kevin D.

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Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders von Di Fabio, Romano, Pellacani, Annalisa, Faedo, Stefania, Roth, Adelheid, Piccoli, Laura, Gerrard, Philip, Porter, Rod A., Johnson, Christopher N., Thewlis, Kevin, Donati, Daniele, Stasi, Luigi, Spada, Simone, Stemp, Geoffrey, Nash, David, Branch, Clive, Kindon, Leanda, Massagrande, Mario, Poffe, Alessandro, Braggio, Simone, Chiarparin, Elisabetta, Marchioro, Carla, Ratti, Emiliangelo, Corsi, Mauro

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Pharmacological characterisation of the GlyT-1 glycine transporter using two novel radioligands von Herdon, Hugh J., Roberts, Jennifer C., Coulton, Steve, Porter, Rod A.

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Characterisation of the binding of [3H]‐SB‐674042, a novel nonpeptide antagonist, to the human orexin‐1 receptor von Langmead, Christopher J, Jerman, Jeffrey C, Brough, Stephen J, Scott, Claire, Porter, Rod A, Herdon, Hugh J

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Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test von Kalinichev, Mikhail, Starr, Kathryn R, Teague, Simon, Bradford, Andrea M, Porter, Rod A, Herdon, Hugh J

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Orexin A Activates Locus Coeruleus Cell Firing and Increases Arousal in the Rat von Hagan, Jim J., Leslie, Ron A., Patel, Sara, Evans, Martyn L., Wattam, Trevor A., Holmes, Steve, Benham, Christopher D., Taylor, Stephen G., Routledge, Carol, Hemmati, Panida, Munton, Richard P., Ashmeade, Tracey E., Shah, Ajit S., Hatcher, Jonathan P., Hatcher, Paula D., Declan N. C. Jones, Smith, Martin I., Piper, David C., Hunter, A. Jackie, Porter, Rod A., Upton, Neil

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Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement von DUXON, Mark S, STRETTON, Jennifer, WAI CHAN, PORTER, Rod A, UPTON, Neil, STARR, Kathryn, JONES, Declan N. C, HOLLAND, Vicky, RILEY, Graham, JERMAN, Jeff, BROUGH, Stephen, SMART, Darren, JOHNS, Amanda

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Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity von JONES, Declan N. C, GARTLON, Jane, PORTER, Rod A, HAGAN, Jim J, HUNTER, A. Jackie, UPTON, Neil, PARKER, Frederick, TAYLOR, Stephen G, ROUTLEDGE, Carol, HEMMATI, Panida, MUNTON, Richard P, ASHMEADE, Tracey E, HATCHER, Jonathan P, JOHNS, Amanda

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Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil von Sellers, Katherine J., Elliott, Christina, Jackson, Joshua, Ghosh, Anshua, Ribe, Elena, Rojo, Ana I., Jarosz-Griffiths, Heledd H., Watson, Iain A., Xia, Weiming, Semenov, Mikhail, Morin, Peter, Hooper, Nigel M., Porter, Rod, Preston, Jane, Al-Shawi, Raya, Baillie, George, Lovestone, Simon, Cuadrado, Antonio, Harte, Michael, Simons, Paul, Srivastava, Deepak P., Killick, Richard

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Abstract 4135: Novel dual A2A A2B adenosine receptor antagonists for cancer immunotherapy: in vitro and in vivo characterization von Galezowski, Michal, Węgrzyn, Paulina, Bobowska, Aneta, Dziedzic, Katarzyna, Szeremeta-Spisak, Joanna, Nowogrodzki, Marcin, Satala, Grzegorz, Obara, Alicja, Lozinska-Raj, Iwona, Dudek, Marcelina, Janiga, Anita, Reus, Jacek, Wronowski, Marek, Zastawna, Magdalena, Statkiewicz, Grzegorz, Rogacki, Maciej, Ziembik, Magdalena, Grycuk, Karolina, Soukou, Foteini, Michalik, Kinga, Adamus, Agnieszka, Wiatrowska, Karolina, Lewandowska, Natalia, Golas, Aniela, Haberkiewicz, Olga, Porter, Rod, Brzozka, Krzysztof, Nowak, Mateusz

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Stereocontrolled Formation of Epoxy Peroxide FunctionalityAppended to a Lactam Ring von Marson, Charles M, Khan, Afzal, Porter, Rod A

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Construction of functionalised medium rings by stereospecific expansions of 2,3-epoxy alcohols under mild conditions von Marson, Charles M., Khan, Afzal, Porter, Rod A., Cobb, Alexander J.A.

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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 von BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

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New quinoline NK3 receptor antagonists with CNS activity von SMITH, Paul W, WYMAN, Paul A, COGGON, Sara, MURKITT, Graham, SEARLE, Kirsten, THOMAS, David R, WATSON, Jeannette M, MARTIN, William, ZINING WU, DAWSON, Lee A, LOVELL, Peter, GOODACRE, Caroline, SERAFINOWSKA, Halina T, VONG, Antonio, HARRINGTON, Frank, FLYNN, Sean, BRADLEY, Daniel M, PORTER, Rod

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Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors von Elliott, Richard J. R., Jarvis, Ashley, Rajasekaran, Mohan B., Menon, Malini, Bowers, Leandra, Boffey, Ray, Bayford, Melanie, Firth-Clark, Stuart, Key, Rebekah, Aqil, Rehan, Kirton, Stewart B., Niculescu-Duvaz, Dan, Fish, Laura, Lopes, Filipa, McLeary, Robert, Trindade, Ines, Vendrell, Elisenda, Munkonge, Felix, Porter, Rod, Perrior, Trevor, Springer, Caroline, Oliver, Antony W., Pearl, Laurence H., Ashworth, Alan, Lord, Christopher J.

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Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitorsElectronic supplementary information (ESI) available: For complete experimental detail... von Elliott, Richard J. R, Jarvis, Ashley, Rajasekaran, Mohan B, Menon, Malini, Bowers, Leandra, Boffey, Ray, Bayford, Melanie, Firth-Clark, Stuart, Key, Rebekah, Aqil, Rehan, Kirton, Stewart B, Niculescu-Duvaz, Dan, Fish, Laura, Lopes, Filipa, McLeary, Robert, Trindade, Ines, Vendrell, Elisenda, Munkonge, Felix, Porter, Rod, Perrior, Trevor, Springer, Caroline, Oliver, Antony W, Pearl, Laurence H, Ashworth, Alan, Lord, Christopher J

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New quinoline NK 3 receptor antagonists with CNS activity von Smith, Paul W., Wyman, Paul A., Lovell, Peter, Goodacre, Caroline, Serafinowska, Halina T., Vong, Antonio, Harrington, Frank, Flynn, Sean, Bradley, Daniel M., Porter, Rod, Coggon, Sara, Murkitt, Graham, Searle, Kirsten, Thomas, David R., Watson, Jeannette M., Martin, William, Wu, Zining, Dawson, Lee A.

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Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX 1 ) receptors, with downstream 5-HT 2C receptor involvement von Duxon, Mark S., Stretton, Jennifer, Starr, Kathryn, Jones, Declan N.C., Holland, Vicky, Riley, Graham, Jerman, Jeff, Brough, Stephen, Smart, Darren, Johns, Amanda, Chan, Wai, Porter, Rod A., Upton, Neil

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Tin (IV)-Mediated Stereoselective Synthesis of Epoxides with Concomitant Alkyl Peroxide Formation von Hursthouse, M

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N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A 2 von Boyd, Helen F., Fell, Stephen C.M., Flynn, Sean T., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Porter, Rod A., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Tew, David G., Theobald, Colin J., Whittaker, Caroline M.

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