Activation of ADAM17 by IL-15 Limits Human NK Cell Proliferation von Mishra, Hemant K., Dixon, Kate J., Pore, Nabendu, Felices, Martin, Miller, Jeffrey S., Walcheck, Bruce

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Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis von Mishra, Hemant K., Ma, Jing, Mendez, Daniel, Hullsiek, Robert, Pore, Nabendu, Walcheck, Bruce

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EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms von PORE, Nabendu, ZIBIN JIANG, GUPTA, Anjali, CERNIGLIA, George, KAO, Gary D, MAITY, Amit

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Akt1 Activation Can Augment Hypoxia-Inducible Factor-1α Expression by Increasing Protein Translation through a Mammalian Target of Rapamycin–Independent Pathway von Pore, Nabendu, Jiang, Zibin, Shu, Hui-Kuo, Bernhard, Eric, Kao, Gary D., Maity, Amit

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Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy von Cerniglia, George J, Pore, Nabendu, Tsai, Jeff H, Schultz, Susan, Mick, Rosemarie, Choe, Regine, Xing, Xiaoman, Durduran, Turgut, Yodh, Arjun G, Evans, Sydney M, Koch, Cameron J, Hahn, Stephen M, Quon, Harry, Sehgal, Chandra M, Lee, William M F, Maity, Amit

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HIV Protease Inhibitors Decrease VEGF/HIF-1α Expression and Angiogenesis in Glioblastoma Cells von Pore, Nabendu, Gupta, Anjali K., Cerniglia, George J., Maity, Amit

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In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors von Pore, Nabendu, Jalla, Sanjoo, Liu, Zheng, Higgs, Brandon, Sorio, Claudio, Scarpa, Aldo, Hollingsworth, Robert, Tice, David A, Michelotti, Emil

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M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo von Curry, Jennifer M, Eubank, Tim D, Roberts, Ryan D, Wang, Yijie, Pore, Nabendu, Maity, Amit, Marsh, Clay B

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Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism von Pore, Nabendu, Liu, Shuang, Shu, Hui-Kuo, Li, Bin, Haas-Kogan, Daphne, Stokoe, David, Milanini-Mongiat, Julie, Pages, Gilles, O'Rourke, Donald M, Bernhard, Eric, Maity, Amit

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Anti-ADAM17 monoclonal antibody MEDI3622 increases IFNγ production by human NK cells in the presence of antibody-bound tumor cells von Mishra, Hemant K., Pore, Nabendu, Michelotti, Emil F., Walcheck, Bruce

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The chemokine receptor CXCR4: A homing device for hypoxic cancer cells? von Pore, Nabendu, Maity, Amit

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Regulation of histone deacetylase 4 expression by the SP family of transcription factors von Liu, Fang, Pore, Nabendu, Kim, Mijin, Voong, K Ranh, Dowling, Melissa, Maity, Amit, Kao, Gary D

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Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdo... von Pore, Nabendu, Wu, Song, Standifer, Nathan, Jure-Kunkel, Maria, de los Reyes, Melissa, Shrestha, Yashaswi, Halpin, Rebecca, Rothstein, Raymond, Mulgrew, Kathy, Blackmore, Stephen, Martin, Philip, Meekin, John, Griffin, Matthew, Bisha, Ina, Proia, Theresa A., Miragaia, Ricardo J., Herbst, Ronald, Gupta, Ashok, Abdullah, Shaad E., Raja, Rajiv, Frigault, Melanie M., Barrett, J. Carl, Dennis, Phillip A., Ascierto, Maria Libera, Oberst, Michael D.

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Preclinical radiolabeling, in vivo biodistribution and positron emission tomography of a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2 von Wichmann, Christian Werner, Burvenich, Ingrid Julienne Georgette, Guo, Nancy, Rigopoulos, Angela, McDonald, Alexander, Cao, Diana, O'Keefe, Graeme Joseph, Gong, Sylvia Jie, Gan, Hui Kong, Scott, Fiona Elizabeth, Pore, Nabendu, Coats, Steven, Scott, Andrew Mark

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Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia von Chen, C, Pore, N, Behrooz, A, Ismail-Beigi, F, Maity, A

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Abstract B57: Effect of ADAM17 inhibition on the release of IFN-y during natural killer cell-mediated antibody dependent cellular cytotoxicity in cancer von Mishra, Hemant K., Jianming, Wu, Pore, Nabendu, Walcheck, Bruce

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Abstract LB-296: Discovery and development of MEDI7247, a novel Pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological and solid canc... von Pore, Nabendu, Borrok, M Jack, Rebellato, Marlon, Hinrichs, MaryJane, Schifferli, Kevin P., Monks, Noel R., Tammali, Ravinder, Herbst, Ronald, Coats, Steven R., Tice, David A.

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Abstract LB-295: MEDI7247, a novel pyrrolobenzodiazepine ADC targeting ASCT2 with potent in vivo activity across a spectrum of hematological malignancies von Monks, Noel R., Schifferli, Kevin P., Tammali, Ravinder, Borrok, M. Jack, Coats, Steven R., Herbst, Ronald, Tice, David A., Pore, Nabendu

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Abstract LB-298: MEDI7247: A first in class antibody drug conjugate targeting ASCT2 in a range of solid tumors von Schifferli, Kevin P., Monks, Noel R., Tammali, Ravinder, Borrok, M Jack, Flynn, Matthew G., Hurt, Elaine M., Coats, Steven R., Herbst, Ronald, Tice, David A., Pore, Nabendu

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Phase 1, First-in-Human Study of MEDI2228, a BCMA-Targeted ADC in Patients with Relapsed/Refractory Multiple Myeloma von Kumar, Shaji K., Migkou, Magdalini, Bhutani, Manisha, Spencer, Andrew, Ailawadhi, Sikander, Kalff, Anna, Walcott, Farzana, Pore, Nabendu, Gibson, Diana, Wang, Fujun, Cheng, Lily, Kagiampakis, Ioannis, Williams, Marna, Kinneer, Krista, Jiang, Yu, Zonder, Jeffrey, Larsen, Jeremy, Sirdesai, Shreerang, Yee, Andrew J., Dimopoulos, Meletios A

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