SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis von Muhar, Matthias, Ebert, Anja, Neumann, Tobias, Umkehrer, Christian, Jude, Julian, Wieshofer, Corinna, Rescheneder, Philipp, Lipp, Jesse J, Herzog, Veronika A, Reichholf, Brian, Cisneros, David A, Hoffmann, Thomas, Schlapansky, Moritz F, Bhat, Pooja, von Haeseler, Arndt, Köcher, Thomas, Obenauf, Anna C, Popow, Johannes, Ameres, Stefan L, Zuber, Johannes

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Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors von Popow, Johannes, Jurkin, Jennifer, Schleiffer, Alexander, Martinez, Javier

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The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells von Jurkin, Jennifer, Henkel, Theresa, Nielsen, Anne Færch, Minnich, Martina, Popow, Johannes, Kaufmann, Therese, Heindl, Katrin, Hoffmann, Thomas, Busslinger, Meinrad, Martinez, Javier

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HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex von Popow, Johannes, Englert, Markus, Weitzer, Stefan, Schleiffer, Alexander, Mierzwa, Beata, Mechtler, Karl, Trowitzsch, Simon, Will, Cindy L, Lührmann, Reinhard, Söll, Dieter, Martinez, Javier

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A transcription factor–based mechanism for mouse heterochromatin formation von Bulut-Karslioglu, Aydan, Perrera, Valentina, Scaranaro, Manuela, de la Rosa-Velazquez, Inti Alberto, van de Nobelen, Suzanne, Shukeir, Nicholas, Popow, Johannes, Gerle, Borbala, Opravil, Susanne, Pagani, Michaela, Meidhof, Simone, Brabletz, Thomas, Manke, Thomas, Lachner, Monika, Jenuwein, Thomas

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Diversity and roles of (t)RNA ligases von Popow, Johannes, Schleiffer, Alexander, Martinez, Javier

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Pan-KRAS inhibitor disables oncogenic signalling and tumour growth von Kim, Dongsung, Herdeis, Lorenz, Rudolph, Dorothea, Zhao, Yulei, Böttcher, Jark, Vides, Alberto, Ayala-Santos, Carlos I., Pourfarjam, Yasin, Cuevas-Navarro, Antonio, Xue, Jenny Y., Mantoulidis, Andreas, Bröker, Joachim, Wunberg, Tobias, Schaaf, Otmar, Popow, Johannes, Wolkerstorfer, Bernhard, Kropatsch, Katrin Gabriele, Qu, Rui, de Stanchina, Elisa, Sang, Ben, Li, Chuanchuan, McConnell, Darryl B., Kraut, Norbert, Lito, Piro

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The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML von Gerlach, Daniel, Tontsch-Grunt, Ulrike, Baum, Anke, Popow, Johannes, Scharn, Dirk, Hofmann, Marco H., Engelhardt, Harald, Kaya, Onur, Beck, Janina, Schweifer, Norbert, Gerstberger, Thomas, Zuber, Johannes, Savarese, Fabio, Kraut, Norbert

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FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation von Popow, Johannes, Alleaume, Anne-Marie, Curk, Tomaz, Schwarzl, Thomas, Sauer, Sven, Hentze, Matthias W

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Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions von Popow, Johannes, Arnhof, Heribert, Bader, Gerd, Berger, Helmut, Ciulli, Alessio, Covini, David, Dank, Christian, Gmaschitz, Teresa, Greb, Peter, Karolyi-Özguer, Jale, Koegl, Manfred, McConnell, Darryl B, Pearson, Mark, Rieger, Maria, Rinnenthal, Joerg, Roessler, Vanessa, Schrenk, Andreas, Spina, Markus, Steurer, Steffen, Trainor, Nicole, Traxler, Elisabeth, Wieshofer, Corinna, Zoephel, Andreas, Ettmayer, Peter

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The RNA ligase RtcB reverses MazF-induced ribosome heterogeneity in Escherichia coli von Temmel, Hannes, Müller, Christian, Sauert, Martina, Vesper, Oliver, Reiss, Ariela, Popow, Johannes, Martinez, Javier, Moll, Isabella

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The FASTK family of proteins: emerging regulators of mitochondrial RNA biology von Jourdain, Alexis A, Popow, Johannes, de la Fuente, Miguel A, Martinou, Jean-Claude, Anderson, Paul, Simarro, Maria

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Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes von Köferle, Anna, Schlattl, Andreas, Hörmann, Alexandra, Thatikonda, Venu, Popa, Alexandra, Spreitzer, Fiona, Ravichandran, Madhwesh C., Supper, Verena, Oberndorfer, Sarah, Puchner, Teresa, Wieshofer, Corinna, Corcokovic, Maja, Reiser, Christoph, Wöhrle, Simon, Popow, Johannes, Pearson, Mark, Martinez, Javier, Weitzer, Stefan, Mair, Barbara, Neumüller, Ralph A.

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Targeting cancer with small-molecule pan-KRAS degraders von Popow, Johannes, Farnaby, William, Gollner, Andreas, Kofink, Christiane, Fischer, Gerhard, Wurm, Melanie, Zollman, David, Wijaya, Andre, Mischerikow, Nikolai, Hasenoehrl, Carina, Prokofeva, Polina, Arnhof, Heribert, Arce-Solano, Silvia, Bell, Sammy, Boeck, Georg, Diers, Emelyne, Frost, Aileen B, Goodwin-Tindall, Jake, Karolyi-Oezguer, Jale, Khan, Shakil, Klawatsch, Theresa, Koegl, Manfred, Kousek, Roland, Kratochvil, Barbara, Kropatsch, Katrin, Lauber, Arnel A, McLennan, Ross, Olt, Sabine, Peter, Daniel, Petermann, Oliver, Roessler, Vanessa, Stolt-Bergner, Peggy, Strack, Patrick, Strauss, Eva, Trainor, Nicole, Vetma, Vesna, Whitworth, Claire, Zhong, Siying, Quant, Jens, Weinstabl, Harald, Kuster, Bernhard, Ettmayer, Peter, Ciulli, Alessio

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Abstract 4449: Synthetic lethality between CSTF2 and CSTF2T in lung adenocarcinoma and melanoma cell lines von Popow, Johannes, Wieshofer, Corinna, Schlattl, Andreas, Woehrle, Simon, Neumüller, Ralph, Petronczki, Mark P., Boettcher, Jark, Koegl, Manfred, Pearson, Mark

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Abstract 1271: In vitro and in vivo characterization of BI 1823911 - a novel KRASG12C selective small molecule inhibitor von Savarese, Fabio, Gollner, Andreas, Rudolph, Dorothea, Lipp, Jesse, Popow, Johannes, Hofmann, Marco H., Arnhof, Heribert, Rinnenthal, Jörg, Trapani, Francesca, Gmachl, Michael, Gerlach, Daniel, Broeker, Joachim, Ettmayer, Peter, Mantoulidis, Andreas, Phan, Jason, Smethurst, Christian A., Treu, Matthias, Waterson, Alex G., Lu, Hengyu, Machado, Annette, Daniele, Joseph, Fesik, Stephan W., Vellano, Christopher P., Heffernan, Timothy P., Marszalek, Joseph R., McConnell, Darryl B., Petronczki, Mark, Kraut, Norbert, Waizenegger, Irene C.

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Abstract C140: BI 1810631 is a novel EGFR wild-type sparing, HER2-selective small molecule inhibitor that efficiently blocks HER2 mutant-driven lung cancer von Neumüller, Ralph A., Wilding, Birgit, Scharn, Dirk, Baum, Anke, Augsten, Martin, Waizenegger, Irene, Kohsaka, Shinji, Santoro, Valeria, Chetta, Paolo, Woelflingseder, Lydia, Popow, Johannes, Gerlach, Daniel, Ettmayer, Peter, Gerstberger, Thomas, Fuchs, Julian, Treu, Matthias, Zahn, Stephan, Pearson, Mark, Petronczki, Mark, McConnell, Darryl B., Kraut, Norbert, Solca, Flavio

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Abstract A087: BI KRASmulti, a first-in-class, orally bioavailable and direct inhibitor of diverse oncogenic KRAS variants drives tumor regression in KRAS G12V-driven preclinical m... von Peng, David H, Tedeschi, Antonio, Herdeis, Lorenz, Savarese, Fabio, Rocchetti, Francesca, Johannes, Popow, Huber, Heinrich J, Melillo, Nicola, Dickinson, Jake, Mistry, Hitesh B, Wilding, Birgit, Treu, Matthias, Fuchs, Julian, Broker, Joachim, Wunberg, Tobias, Schischlik, Fiorella, Lipp, Jesse, Ramamoorthy, Vandhana, Daniele, Joseph R, Kopetz, Scott, Kim, Michael, Gibbons, Don L, Vellano, Christopher P, Marszalek, Joseph R, Heffernan, Timothy P, McConnell, Darryl, Pearson, Mark, Kraut, Norbert, Rudolph, Dorothea

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Abstract 4004: Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sex chromosome encoded genes von Köferle, Anna, Schlattl, Andreas, Hörmann, Alexandra, Spreitzer, Fiona, Popa, Alexandra, Thatikonda, Venu, Puchner, Teresa, Supper, Verena, Ravichandran, Madhwesh C., Oberndorfer, Sarah, Wieshofer, Corinna, Corcokovic, Maja, Reiser, Christoph, Wöhrle, Simon, Popow, Johannes, Pearson, Mark, Mair, Barbara, Neumüller, Ralph A.

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A transcription factor-based mechanism for mouse heterochromatin formation von Bulut-karslioglu, Aydan, Perrera, Valentina, Scaranaro, Manuela, De La Rosa-velazquez, Inti Alberto, Van De Nobelen, Suzanne, Shukeir, Nicholas, Popow, Johannes, Gerle, Borbala, Opravil, Susanne, Pagani, Michaela, Meidhof, Simone, Brabletz, Thomas, Manke, Thomas, Lachner, Monika, Jenuwein, Thomas

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