Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes von Béliveau, François, Tarkar, Aarti, Dion, Sébastien P., Désilets, Antoine, Ghinet, Mariana Gabriela, Boudreault, Pierre-Luc, St-Georges, Catherine, Marsault, Éric, Paone, Daniel, Collins, Jon, Macphee, Colin H., Campobasso, Nino, Groy, Arthur, Cottom, Josh, Ouellette, Michael, Pope, Andrew J., Leduc, Richard

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High-throughput screening: new technology for the 21st century von Hertzberg, Robert P, Pope, Andrew J

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Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Re... von Wu, Zining, Graybill, Todd L, Zeng, Xin, Platchek, Michael, Zhang, Jean, Bodmer, Vera Q, Wisnoski, David D, Deng, Jianghe, Coppo, Frank T, Yao, Gang, Tamburino, Alex, Scavello, Genaro, Franklin, G. Joseph, Mataruse, Sibongile, Bedard, Katie L, Ding, Yun, Chai, Jing, Summerfield, Jennifer, Centrella, Paolo A, Messer, Jeffrey A, Pope, Andrew J, Israel, David I

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Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic–Industry Partnership von Mo, Charlie Y, Culyba, Matthew J, Selwood, Trevor, Kubiak, Jeffrey M, Hostetler, Zachary M, Jurewicz, Anthony J, Keller, Paul M, Pope, Andrew J, Quinn, Amy, Schneck, Jessica, Widdowson, Katherine L, Kohli, Rahul M

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Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens von Diaz, Elsie, Machutta, Carl A., Chen, Stephanie, Jiang, Yong, Nixon, Christopher, Hofmann, Glenn, Key, Danielle, Sweitzer, Sharon, Patel, Mehul, Wu, Zining, Creasy, Caretha L., Kruger, Ryan G., LaFrance, Louis, Verma, Sharad K., Pappalardi, Melissa B., Le, Baochau, Van Aller, Glenn S., McCabe, Michael T., Tummino, Peter J., Pope, Andrew J., Thrall, Sara H., Schwartz, Benjamin, Brandt, Martin

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Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Pr... von Sosa, Yvett, Deniskin, Roman, Frame, I. J, Steiginga, Matthew S, Bandyopadhyay, Deepak, Graybill, Todd L, Kallal, Lorena A, Ouellette, Michael T, Pope, Andrew J, Widdowson, Katherine L, Young, Robert J, Akabas, Myles H

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A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation von Liu, Yan, Platchek, Michael, Kement, Burcu, Bee, Weilin T, Truong, Maggie, Zeng, Xin, Hung, Sunny, Lin, Hong, Morrow, Dwight, Kallal, Lorena A, Xie, Qing, Agarwal, Pankaj, Pope, Andrew J, Wu, Zining

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A High-Content Imaging Screen for Cellular Regulators of β-Catenin Protein Abundance von Zeng, Xin, Montoute, Monica, Bee, Tiger W., Lin, Hong, Kallal, Lorena A., Liu, Yan, Agarwal, Pankaj, Wang, Dayuan, Lu, Quinn, Morrow, Dwight, Pope, Andrew J., Wu, Zining

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Homogeneous fluorescence readouts for miniaturized high-throughput screening: theory and practice von Pope, Andrew J, Haupts, Ulrich M, Moore, Keith J

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Single-Molecule Detection Technologies in Miniaturized High-Throughput Screening: Fluorescence Intensity Distribution Analysis von Haupts, Ulrich, Rüdiger, Martin, Ashman, Stephen, Turconi, Sandra, Bingham, Ryan, Wharton, Charlotte, Hutchinson, Jonathan, Carey, Charlotte, Moore, Keith J., Pope, Andrew J.

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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase von Brown, Murray J., Carter, Paul S., Fenwick, Ashley E., Fosberry, Andrew P., Hamprecht, Dieter W., Hibbs, Martin J., Jarvest, Richard L., Mensah, Lucy, Milner, Peter H., O'Hanlon, Peter J., Pope, Andrew J., Richardson, Christine M., West, Andrew, Witty, David R.

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Perspectives on the Discovery of Small-Molecule Modulators for Epigenetic Processes von Lu, Quinn, Quinn, Amy M., Patel, Mehul P., Semus, Simon F., Graves, Alan P., Bandyopadhyay, Deepak, Pope, Andrew J., Thrall, Sara H.

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SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp: I. Fermentation, Isolation and Properties von STEFANSKA, ANNA L, COATES, NIGEL J., MENSAH, LUCY M., POPE, ANDREW J., READY, SARAH J., WARR, STEPHEN. R.

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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens von JARVEST, Richard L., BERGE, John M., BERRY, Valerie, BOYD, Helen F., BROWN, Murray J., ELDER, John S., FORREST, Andrew K., FOSBERRY, Andrew P., GENTRY, Daniel R., HIBBS, Martin J., JAWORSKI, Deborah D., O'HANLON, Peter J., POPE, Andrew J., RITTENHOUSE, Stephen, SHEPPARD, Robert J., SLATER-RADOSTI, Courtney, WORBY, Angela

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Development of Phenotypic Screening Assays for γ-Globin Induction Using Primary Human Bone Marrow Day 7 Erythroid Progenitor Cells von Li, Hu, Xie, Wensheng, Gore, Elizabeth R., Montoute, Monica N., Bee, Weilin Tiger, Zappacosta, Francesca, Zeng, Xin, Wu, Zining, Kallal, Lorena, Ames, Robert S., Pope, Andrew J., Benowitz, Andrew, Erickson-Miller, Connie L.

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Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase von BERGE, JOHN M., BROOM, NIGEL J. P., HOUGE-FRYDRYCH, CATHERINE S. V., JARVEST, RICHARD L., MENSAH, LUCY, MCNAIR, DAVID J., O'HANLON, PETER J., POPE, ANDREW J., RITTENHOUSE, STEPHEN

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Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A von Brown, Murray J. B, Mensah, Lucy M, Doyle, Michael L, Broom, Nigel J. P, Osbourne, Neal, Forrest, Andrew K, Richardson, Christine M, O'Hanlon, Peter J, Pope, Andrew J

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Fluorescence correlation spectroscopy: lead discovery by miniaturized HTS von Auer, Manfred, Moore, Keith J, Meyer-Almes, Franz J, Guenther, Rolf, Pope, Andrew J, Stoeckli, Kurt A

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Kinetics of the vacuolar H+-pyrophosphatase. The roles of magnesium, pyrophosphate, and their complexes as substrates, activators, and inhibitors von Leigh, Roger A., Andrew J. Pope, Ian R. Jennings, Sanders, Dale

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Developments in fluorescence lifetime-based analysis for ultra-HTS von Turconi, Sandra, Bingham, Ryan P., Haupts, Ulrich, Pope, Andrew J.

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