Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition von Irving, Julie, Matheson, Elizabeth, Minto, Lynne, Blair, Helen, Case, Marian, Halsey, Christina, Swidenbank, Isabella, Ponthan, Frida, Kirschner-Schwabe, Renate, Groeneveld-Krentz, Stefanie, Hof, Jana, Allan, James, Harrison, Christine, Vormoor, Josef, von Stackelberg, Arend, Eckert, Cornelia

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Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer von Green, Darrell, Eyre, Heather, Singh, Archana, Taylor, Jessica T., Chu, Jason, Jeys, Lee, Sumathi, Vaiyapuri, Coonar, Aman, Rassl, Doris, Babur, Muhammad, Forster, Duncan, Alzabin, Saba, Ponthan, Frida, McMahon, Adam, Bigger, Brian, Reekie, Tristan, Kassiou, Michael, Williams, Kaye, Dalmay, Tamas, Fraser, William D., Finegan, Katherine G.

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MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia von Kerry, Jon, Godfrey, Laura, Repapi, Emmanouela, Tapia, Marta, Blackledge, Neil P., Ma, Helen, Ballabio, Erica, O’Byrne, Sorcha, Ponthan, Frida, Heidenreich, Olaf, Roy, Anindita, Roberts, Irene, Konopleva, Marina, Klose, Robert J., Geng, Huimin, Milne, Thomas A.

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Cell survival signalling through PPARδ and arachidonic acid metabolites in neuroblastoma von Bell, Emma, Ponthan, Frida, Whitworth, Claire, Westermann, Frank, Thomas, Huw, Redfern, Christopher P F

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The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo von Eliassen, Liv Tone, Berge, Gerd, Leknessund, Arild, Wikman, Mari, Lindin, Inger, Løkke, Cecilie, Ponthan, Frida, Johnsen, John Inge, Sveinbjørnsson, Baldur, Kogner, Per, Flægstad, Trond, Rekdal, Øystein

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Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO von Osman, Dani, Gobert, Vanessa, Ponthan, Frida, Heidenreich, Olaf, Haenlin, Marc, Waltzer, Lucas

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Neuroblastoma cell death in response to docosahexaenoic acid: Sensitization to chemotherapy and arsenic‐induced oxidative stress von Lindskog, Magnus, Gleissman, Helena, Ponthan, Frida, Castro, Juan, Kogner, Per, Johnsen, John Inge

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Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo von JOHNSEN, John I, LINDSKOG, Magnus, PONTHAN, Frida, PETTERSEN, Ingvild, ELFMAN, Lotta, ORREGO, Abiel, SVEINBJÖRNSSON, Baldur, KOGNER, Per

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Celecoxib Prevents Neuroblastoma Tumor Development and Potentiates the Effect of Chemotherapeutic Drugs In vitro and In vivo von Ponthan, Frida, Wickström, Malin, Gleissman, Helena, Fuskevåg, Ole M, Segerström, Lova, Sveinbjörnsson, Baldur, Redfern, Christopher P F, Eksborg, Staffan, Kogner, Per, Johnsen, John I

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The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo von Wickström, Malin, Johnsen, John Inge, Ponthan, Frida, Segerström, Lova, Sveinbjörnsson, Baldur, Lindskog, Magnus, Lövborg, Henrik, Viktorsson, Kristina, Lewensohn, Rolf, Kogner, Per, Larsson, Rolf, Gullbo, Joachim

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Abstract 1061: Animal models of prostate cancer von Ponthan, Frida, Brown, Matthew, Playle, Emma, Booth, Catherine

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Abstract 1718: Characterization of infiltrating immune cells after irradiation using 10x genomics single cell sequencing von Ponthan, Frida, Ubertini, Valentina, Beale, Gary

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Abstract 2754: Transwell-grown monolayers derived from small intestinal organoids to study the effects of tight junction modulators that may improve the absorption of orally-admini... von Ubertini, Valentina, Ponthan, Frida, Bonavita, Aude-Marine, Wilson, James

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Abstract 1886: Targeting oral squamous cell carcinoma tumor microenvironment through simultaneous modulation of pattern recognition receptors and angiogenic factors using a synthet... von Lee, Won Yong, Ponthan, Frida, Sonis, Stephen T.

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Abstract 374: Small intestinal organoids to study the effects of tight junction modulators that may improve the absorption of orally-administered, anti-neoplastic drugs von Ubertini, Valentina, French, Stephanie, Wilson, James, Ponthan, Frida

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The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia von Sankar, Shalini, Guillen Navarro, Miriam, Ponthan, Frida, Bomken, Simon, Nakjang, Sirintra, Grinev, Vasily, McNeill, Hesta, Zwaan, Michel C, Vormoor, Josef, Stam, Ronald W., Heidenreich, Olaf

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Abstract 3921: The use of a novel in vivo orthotopic imaging model of AML for assessment of drug efficacy von Batey, Michael A., Ponthan, Frida, Heidenreich, Olaf

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Abstract 4350: Pharmacodynamic biomarkers: Evaluation of oncology drug target engagement in human plucked scalp and beard hair von Tudor, Greg, Ponthan, Frida, Boanas, Adam, Bonavita, Aude-Marine, Booth, Catherine

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Abstract 2057: The development and evaluation of a series of novel in vivo imaging models of AML for the assessment of drug efficacy von Batey, Michael A., Ponthan, Frida, Blair, Helen J., Heidenreich, Olaf

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A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL von Ponthan, Frida, Bomken, Simon, Pal, Deepali, Elder, Alex, McNeill, Hesta, Vormoor, Josef, Heidenreich, Olaf

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