Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors von Webber, Beau R., Lonetree, Cara-lin, Kluesner, Mitchell G., Johnson, Matthew J., Pomeroy, Emily J., Diers, Miechaleen D., Lahr, Walker S., Draper, Garrett M., Slipek, Nicholas J., Smeester, Branden A., Lovendahl, Klaus N., McElroy, Amber N., Gordon, Wendy R., Osborn, Mark J., Moriarity, Branden S.

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A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy von Pomeroy, Emily J., Hunzeker, John T., Kluesner, Mitchell G., Lahr, Walker S., Smeester, Branden A., Crosby, Margaret R., Lonetree, Cara-lin, Yamamoto, Kenta, Bendzick, Laura, Miller, Jeffrey S., Geller, Melissa A., Walcheck, Bruce, Felices, Martin, Webber, Beau R., Starr, Timothy K., Moriarity, Branden S.

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Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments von Tabdanov, Erdem D., Rodríguez-Merced, Nelson J., Cartagena-Rivera, Alexander X., Puram, Vikram V., Callaway, Mackenzie K., Ensminger, Ethan A., Pomeroy, Emily J., Yamamoto, Kenta, Lahr, Walker S., Webber, Beau R., Moriarity, Branden S., Zhovmer, Alexander S., Provenzano, Paolo P.

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CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells von Kluesner, Mitchell G., Lahr, Walker S., Lonetree, Cara-lin, Smeester, Branden A., Qiu, Xiaohong, Slipek, Nicholas J., Claudio Vázquez, Patricia N., Pitzen, Samuel P., Pomeroy, Emily J., Vignes, Madison J., Lee, Samantha C., Bingea, Samuel P., Andrew, Aneesha A., Webber, Beau R., Moriarity, Branden S.

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Nonviral genome engineering of natural killer cells von Robbins, Gabrielle M, Wang, Minjing, Pomeroy, Emily J, Moriarity, Branden S

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PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma von Smeester, Branden A., Slipek, Nicholas J., Pomeroy, Emily J., Laoharawee, Kanut, Osum, Sara H., Larsson, Alex T., Williams, Kyle B., Stratton, Natalie, Yamamoto, Kenta, Peterson, Joseph J., Rathe, Susan K., Mills, Lauren J., Hudson, Wendy A., Crosby, Margaret R., Wang, Minjing, Rahrmann, Eric P., Moriarity, Branden S., Largaespada, David A.

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Genetic and epigenetic modification of human primary NK cells for enhanced antitumor activity von Naeimi Kararoudi, Meisam, Tullius, Brian P., Chakravarti, Nitin, Pomeroy, Emily J., Moriarity, Branden S., Beland, Kathie, Colamartino, Aurelien B.L., Haddad, Elie, Chu, Yaya, Cairo, Mitchell S., Lee, Dean A.

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Author Correction: Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors von Webber, Beau R., Lonetree, Cara-lin, Kluesner, Mitchell G., Johnson, Matthew J., Pomeroy, Emily J., Diers, Miechaleen D., Lahr, Walker S., Draper, Garrett M., Slipek, Nicholas J., Smeester, Branden A., Lovendahl, Klaus N., McElroy, Amber N., Gordon, Wendy R., Osborn, Mark J., Moriarity, Branden S.

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An Indole–Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules von Cong, Hui, Zhao, Xinghua, Castle, Brian T, Pomeroy, Emily J, Zhou, Bo, Lee, John, Wang, Yi, Bian, Tengfei, Miao, Zhenyuan, Zhang, Wannian, Sham, Yuk Yin, Odde, David J, Eckfeldt, Craig E, Xing, Chengguo, Zhuang, Chunlin

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Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies von Skeate, Joseph G., Pomeroy, Emily J., Slipek, Nicholas J., Jones, Bryan J., Wick, Bryce J., Chang, Jae-Woong, Lahr, Walker S., Stelljes, Erin M., Patrinostro, Xiaobai, Barnes, Blake, Zarecki, Trevor, Krueger, Joshua B., Bridge, Jacob E., Robbins, Gabrielle M., McCormick, Madeline D., Leerar, John R., Wenzel, Kari T., Hornberger, Kathlyn M., Walker, Kirsti, Smedley, Dalton, Largaespada, David A., Otto, Neil, Webber, Beau R., Moriarity, Branden S.

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Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production von Dahlvang, James D, Dick, Jenna K, Sangala, Jules A, Kennedy, Philippa R, Pomeroy, Emily J, Snyder, Kristin M, Moushon, Juliette M, Thefaine, Claire E, Wu, Jianming, Hamilton, Sara E, Felices, Martin, Miller, Jeffrey S, Walcheck, Bruce, Webber, Beau R, Moriarity, Branden S, Hart, Geoffrey T

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Targeting Ras signaling in AML: RALB is a small GTPase with big potential von Pomeroy, Emily J., Eckfeldt, Craig E.

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Implication of ZNF217 in Accelerating Tumor Development and Therapeutically Targeting ZNF217-Induced PI3K-AKT Signaling for the Treatment of Metastatic Osteosarcoma von Smeester, Branden A, Draper, Garrett M, Slipek, Nicholas J, Larsson, Alex T, Stratton, Natalie, Pomeroy, Emily J, Becklin, Kelsie L, Yamamoto, Kenta, Williams, Kyle B, Laoharawee, Kanut, Peterson, Joseph J, Abrahante, Juan E, Rathe, Susan K, Mills, Lauren J, Crosby, Margaret R, Hudson, Wendy A, Rahrmann, Eric P, Largaespada, David A, Moriarity, Branden S

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SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis von Smeester, Branden A., Slipek, Nicholas J., Pomeroy, Emily J., Bomberger, Heather E., Shamsan, Ghaidan A., Peterson, Joseph J., Crosby, Margaret R., Draper, Garrett M., Becklin, Kelsie L., Rahrmann, Eric P., McCarthy, James B., Odde, David J., Wood, David K., Largaespada, David A., Moriarity, Branden S.

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Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency von Sachs, Zohar, Been, Raha A, DeCoursin, Krista J, Nguyen, Hanh T, Mohd Hassan, Nurul A, Noble-Orcutt, Klara E, Eckfeldt, Craig E, Pomeroy, Emily J, Diaz-Flores, Ernesto, Geurts, Jennifer L, Diers, Miechaleen D, Hasz, Diane E, Morgan, Kelly J, MacMillan, Margaret L, Shannon, Kevin M, Largaespada, David A, Wiesner, Stephen M

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RALB provides critical survival signals downstream of Ras in acute myeloid leukemia von Eckfeldt, Craig E, Pomeroy, Emily J, Lee, Robin D W, Hazen, Katherine S, Lee, Lindsey A, Moriarity, Branden S, Largaespada, David A

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Multiplex Prime Editing and PASSIGE TM for Non-Viral Generation of an Allogeneic CAR-T Cell Product von Pomeroy, Emily J, Anzalone, Andrew V, Podracky, Christopher J, Bloch, Noah B, Chang, Reyna, Dwivedi, Arika A, Laoharawee, Kanut, Wilhelm, Alan J, Waterman, David P, Tedeschi, Justin G, Arvindam, Upasana Sunil, Macari, Elizabeth R, Gori, Jennifer L, Duffield, Jeremy S

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Ablation of SYK kinase from expanded primary human Natural Killer cells via CRISPR/Cas9 enhances cytotoxicity and cytokine production von Dahlvang, James D., Dick, Jenna K., Sangala, Jules A., Kennedy, Philippa R., Pomeroy, Emily J., Snyder, Kristin M., Moushon, Juliette M., Thefaine, Claire E., Wu, Jianming, Hamilton, Sara E., Felices, Martin, Miller, Jeffrey S., Walcheck, Bruce, Webber, Beau R., Moriarity, Branden S., Hart, Geoffrey T.

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Ras Effector Pathways Differentially Support Proliferation and Survival of Acute Myeloid Leukemia von Eckfeldt, Craig E, Pomeroy, Emily J, Lee, Robin DW, Hazen, Katherine S, Moriarity, Branden S, Largaespada, David A

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Abstract B01: Mechanisms of treatment resistance following Ras targeted therapy in acute myeloid leukemia von Eckfeldt, Craig E., Lee, Robin DW, Pomeroy, Emily J., Temiz, Alpay N., Rathe, Susan K., Ma, Jing, Gruber, Tanja A., Diaz-Flores, Ernesto, Downing, James R., Shannon, Kevin M., Largaespada, David A.

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