Succinate: A New Epigenetic Hacker von Yang, Ming, Pollard, Patrick J.

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Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling von Adam, Julie, Hatipoglu, Emine, O'Flaherty, Linda, Ternette, Nicola, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Nye, Emma, Stamp, Gordon W., Wolhuter, Kathryn, Stevens, Marcus, Fischer, Roman, Carmeliet, Peter, Maxwell, Patrick H., Pugh, Chris W., Frizzell, Norma, Soga, Tomoyoshi, Kessler, Benedikt M., El-Bahrawy, Mona, Ratcliffe, Peter J., Pollard, Patrick J.

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Inborn and acquired metabolic defects in cancer von Frezza, Christian, Pollard, Patrick J, Gottlieb, Eyal

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Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway von Ashrafian, Houman, Czibik, Gabor, Bellahcene, Mohamed, Aksentijević, Dunja, Smith, Anthony C., Mitchell, Sarah J., Dodd, Michael S., Kirwan, Jennifer, Byrne, Jonathan J., Ludwig, Christian, Isackson, Henrik, Yavari, Arash, Støttrup, Nicolaj B., Contractor, Hussain, Cahill, Thomas J., Sahgal, Natasha, Ball, Daniel R., Birkler, Rune I.D., Hargreaves, Iain, Tennant, Daniel A., Land, John, Lygate, Craig A., Johannsen, Mogens, Kharbanda, Rajesh K., Neubauer, Stefan, Redwood, Charles, de Cabo, Rafael, Ahmet, Ismayil, Talan, Mark, Günther, Ulrich L., Robinson, Alan J., Viant, Mark R., Pollard, Patrick J., Tyler, Damian J., Watkins, Hugh

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Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α von Pollard, Patrick J., Loenarz, Christoph, Mole, David R., McDonough, Michael A., Gleadle, Jonathan M., Schofield, Christopher J., Ratcliffe, Peter J.

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Oncometabolites: linking altered metabolism with cancer von Yang, Ming, Soga, Tomoyoshi, Pollard, Patrick J

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Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency von Ternette, Nicola, Yang, Ming, Laroyia, Mahima, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Wolhulter, Kathryn, Igarashi, Kaori, Saito, Kaori, Kato, Keiko, Fischer, Roman, Berquand, Alexandre, Kessler, Benedikt M., Lappin, Terry, Frizzell, Norma, Soga, Tomoyoshi, Adam, Julie, Pollard, Patrick J.

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OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation von Singleton, Rachelle S., Liu-Yi, Phebee, Formenti, Fabio, Ge, Wei, Sekirnik, Rok, Fischer, Roman, Adam, Julie, Pollard, Patrick J., Wolf, Alexander, Thalhammer, Armin, Loenarz, Christoph, Flashman, Emily, Yamamoto, Atsushi, Coleman, Mathew L., Kessler, Benedikt M., Wappner, Pablo, Schofield, Christopher J., Ratcliffe, Peter J., Cockman, Matthew E.

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Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α) von Thalhammer, Armin, Bencokova, Zuzana, Poole, Rachel, Loenarz, Christoph, Adam, Julie, O'Flaherty, Linda, Schödel, Johannes, Mole, David, Giaslakiotis, Konstantinos, Schofield, Christopher J, Hammond, Ester M, Ratcliffe, Peter J, Pollard, Patrick J

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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status von Bardella, Chiara, El-Bahrawy, Mona, Frizzell, Norma, Adam, Julie, Ternette, Nicola, Hatipoglu, Emine, Howarth, Kimberley, O'Flaherty, Linda, Roberts, Ian, Turner, Gareth, Taylor, Jennifer, Giaslakiotis, Konstantinos, Macaulay, Valentine M, Harris, Adrian L, Chandra, Ashish, Lehtonen, Heli J, Launonen, Virpi, Aaltonen, Lauri A, Pugh, Christopher W, Mihai, Radu, Trudgian, David, Kessler, Benedikt, Baynes, John W, Ratcliffe, Peter J, Tomlinson, Ian P, Pollard, Patrick J

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SDH mutations in cancer von Bardella, Chiara, Pollard, Patrick J., Tomlinson, Ian

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A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia von Adam, Julie, Yang, Ming, Bauerschmidt, Christina, Kitagawa, Mitsuhiro, O’Flaherty, Linda, Maheswaran, Pratheesh, Özkan, Gizem, Sahgal, Natasha, Baban, Dilair, Kato, Keiko, Saito, Kaori, Iino, Keiko, Igarashi, Kaori, Stratford, Michael, Pugh, Christopher, Tennant, Daniel A., Ludwig, Christian, Davies, Benjamin, Ratcliffe, Peter J., El-Bahrawy, Mona, Ashrafian, Houman, Soga, Tomoyoshi, Pollard, Patrick J.

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Bone Marrow‐Derived Cells Contribute to Podocyte Regeneration and Amelioration of Renal Disease in a Mouse Model of Alport Syndrome von Prodromidi, Evangelia I., Poulsom, Richard, Jeffery, Rosemary, Roufosse, Candice A., Pollard, Patrick J., Pusey, Charles D., Cook, H. Terence

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Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem Cells von Gezer, Deniz, Vukovic, Milica, Soga, Tomoyoshi, Pollard, Patrick J., Kranc, Kamil R.

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Rewiring Mitochondrial Pyruvate Metabolism: Switching Off the Light in Cancer Cells? von Szlosarek, Peter W., Lee, SukJun, Pollard, Patrick J.

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Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism von O'Flaherty, Linda, Adam, Julie, Heather, Lisa C., Zhdanov, Alexander V., Chung, Yuen-Li, Miranda, Melroy X., Croft, Joanne, Olpin, Simon, Clarke, Kieran, Pugh, Christopher W., Griffiths, John, Papkovsky, Dmitri, Ashrafian, Houman, Ratcliffe, Peter J., Pollard, Patrick J.

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Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway von Pollard, Patrick J., Spencer-Dene, Bradley, Shukla, Deepa, Howarth, Kimberley, Nye, Emma, El-Bahrawy, Mona, Deheragoda, Maesha, Joannou, Maria, McDonald, Stuart, Martin, Alison, Igarashi, Peter, Varsani-Brown, Sunita, Rosewell, Ian, Poulsom, Richard, Maxwell, Patrick, Stamp, Gordon W., Tomlinson, Ian P.M.

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Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia von Papathomas, Thomas G, Oudijk, Lindsey, Zwarthoff, Ellen C, Post, Edward, Duijkers, Floor A, van Noesel, Max M, Hofland, Leo J, Pollard, Patrick J, Maher, Eamonn R, Restuccia, David F, Feelders, Richard A, Franssen, Gaston J H, Timmers, Henri J, Sleijfer, Stefan, de Herder, Wouter W, de Krijger, Ronald R, Dinjens, Winand N M, Korpershoek, Esther

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Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism von Bardella, Chiara, Olivero, Martina, Lorenzato, Annalisa, Geuna, Massimo, Adam, Julie, O'Flaherty, Linda, Rustin, Pierre, Tomlinson, Ian, Pollard, Patrick J., Di Renzo, Maria Flavia

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Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts von Mole, David R., Blancher, Christine, Copley, Richard R., Pollard, Patrick J., Gleadle, Jonathan M., Ragoussis, Jiannis, Ratcliffe, Peter J.

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