Synthesis of Sulfones from Organozinc Reagents, DABSO, and Alkyl Halides von Rocke, Benjamin N, Bahnck, Kevin B, Herr, Michael, Lavergne, Sophie, Mascitti, Vincent, Perreault, Christian, Polivkova, Jana, Shavnya, Andrei

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Hydroarylation of 2-azabicyclohept-5-en-3-one von Piotrowski, David W., Polivkova, Jana

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cis-2,5-Dicyanopyrrolidine Inhibitors of Dipeptidyl Peptidase IV:  Synthesis and in Vitro, in Vivo, and X-ray Crystallographic Characterization von Wright, Stephen W, Ammirati, Mark J, Andrews, Kim M, Brodeur, Anne M, Danley, Dennis E, Doran, Shawn D, Lillquist, Jay S, McClure, Lester D, McPherson, R. Kirk, Orena, Stephen J, Parker, Janice C, Polivkova, Jana, Qiu, Xiayang, Soeller, Walter C, Soglia, Carolyn B, Treadway, Judith L, VanVolkenburg, Maria A, Wang, Hong, Wilder, Donald C, Olson, Thanh V

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Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactamsElectronic supplementary information (ESI) available. See DOI: 10.1039/c6ob01126h von Canterbury, Daniel P, Hesp, Kevin D, Polivkova, Jana

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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis von Futatsugi, Kentaro, Cabral, Shawn, Kung, Daniel W., Huard, Kim, Lee, Esther, Boehm, Markus, Bauman, Jonathan, Clark, Ronald W., Coffey, Steven B., Crowley, Collin, Dechert-Schmitt, Anne-Marie, Dowling, Matthew S., Dullea, Robert, Gosset, James R., Kalgutkar, Amit S., Kou, Kou, Li, Qifang, Lian, Yajing, Loria, Paula M., Londregan, Allyn T., Niosi, Mark, Orozco, Christine, Pettersen, John C., Pfefferkorn, Jeffrey A., Polivkova, Jana, Ross, Trenton T., Sharma, Raman, Stock, Ingrid A., Tesz, Gregory, Wisniewska, Hanna, Goodwin, Bryan, Price, David A.

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Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss von Garnsey, Michelle R., Smith, Aaron C., Polivkova, Jana, Arons, Autumn L., Bai, Guoyun, Blakemore, Caroline, Boehm, Markus, Buzon, Leanne M., Campion, Sarah N., Cerny, Matthew, Chang, Shiao-Chi, Coffman, Karen, Farley, Kathleen A., Fonseca, Kari R., Ford, Kristen K., Garren, Jeonifer, Kong, Jimmy X., Koos, Martin R. M., Kung, Daniel W., Lian, Yajing, Li, Monica M., Li, Qifang, Martinez-Alsina, Luis A., O’Connor, Rebecca, Ogilvie, Kevin, Omoto, Kiyoyuki, Raymer, Brian, Reese, Matthew R., Ryder, Tim, Samp, Lacey, Stevens, Kimberly A., Widlicka, Daniel W., Yang, Qingyi, Zhu, Kaicheng, Fortin, Jean-Philippe, Sammons, Matthew F.

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Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams von Canterbury, Daniel P, Hesp, Kevin D, Polivkova, Jana

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Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups von Aspnes, Gary E., Coffey, Steven B., Darout, Etzer, Dechert-Schmitt, Anne-Marie, Dullea, Robert G., Kamlet, Adam S., Limberakis, Chris, Londregan, Allyn T., McClure, Kim F., Menhaji-Klotz, Elnaz, Piotrowski, David W., Polivkova, Jana, Raymer, Brian, Ruggeri, Roger B., Salatto, Christopher T., Tu, Meihua, Wei, Liuqing, Xiao, Jun

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Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting von Huard, Kim, Smith, Aaron C, Cappon, Gregg, Dow, Robert L, Edmonds, David J, El-Kattan, Ayman, Esler, William P, Fernando, Dilinie P, Griffith, David A, Kalgutkar, Amit S, Ross, Trenton T, Bagley, Scott W, Beebe, David, Bi, Yi-An, Cabral, Shawn, Crowley, Collin, Doran, Shawn D, Dowling, Matthew S, Liras, Spiros, Mascitti, Vincent, Niosi, Mark, Pfefferkorn, Jeffrey A, Polivkova, Jana, Préville, Cathy, Price, David A, Shavnya, Andre, Shirai, Norimitsu, Smith, Andrew H, Southers, James R, Tess, David A, Thuma, Benjamin A, Varma, Manthena V, Yang, Xiaojing

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Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family von Huard, Kim, Gosset, James R, Montgomery, Justin I, Gilbert, Adam, Hayward, Matthew M, Magee, Thomas V, Cabral, Shawn, Uccello, Daniel P, Bahnck, Kevin, Brown, Janice, Purkal, Julie, Gorgoglione, Matthew, Lanba, Adhiraj, Futatsugi, Kentaro, Herr, Michael, Genung, Nathan E, Aspnes, Gary, Polivkova, Jana, Garcia-Irizarry, Carmen N, Li, Qifang, Canterbury, Daniel, Niosi, Mark, Vera, Nicholas B, Li, Zhenhong, Khunte, Bhagyashree, Siderewicz, Jaclyn, Rolph, Timothy, Erion, Derek M

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Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure von Griffith, David A, Dow, Robert L, Huard, Kim, Edmonds, David J, Bagley, Scott W, Polivkova, Jana, Zeng, Dongxiang, Garcia-Irizarry, Carmen N, Southers, James A, Esler, William, Amor, Paul, Loomis, Kathrine, McPherson, Kirk, Bahnck, Kevin B, Préville, Cathy, Banks, Tereece, Moore, Dianna E, Mathiowetz, Alan M, Menhaji-Klotz, Elnaz, Smith, Aaron C, Doran, Shawn D, Beebe, David A, Dunn, Matthew F

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Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK) von Edmonds, David J, Kung, Daniel W, Kalgutkar, Amit S, Filipski, Kevin J, Ebner, David C, Cabral, Shawn, Smith, Aaron C, Aspnes, Gary E, Bhattacharya, Samit K, Borzilleri, Kris A, Brown, Janice A, Calabrese, Matthew F, Caspers, Nicole L, Cokorinos, Emily C, Conn, Edward L, Dowling, Matthew S, Eng, Heather, Feng, Bo, Fernando, Dilinie P, Genung, Nathan E, Herr, Michael, Kurumbail, Ravi G, Lavergne, Sophie Y, Lee, Esther C.-Y, Li, Qifang, Mathialagan, Sumathy, Miller, Russell A, Panteleev, Jane, Polivkova, Jana, Rajamohan, Francis, Reyes, Allan R, Salatto, Christopher T, Shavnya, Andre, Thuma, Benjamin A, Tu, Meihua, Ward, Jessica, Withka, Jane M, Xiao, Jun, Cameron, Kimberly O

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Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model von Garnsey, Michelle R, Robinson, Matthew C, Nguyen, Luong T, Cardin, Rhonda, Tillotson, Joseph, Mashalidis, Ellene, Yu, Aijia, Aschenbrenner, Lisa, Balesano, Amanda, Behzadi, Amin, Boras, Britton, Chang, Jeanne S, Eng, Heather, Ephron, Andrew, Foley, Tim, Ford, Kristen K, Frick, James M, Gibson, Scott, Hao, Li, Hurst, Brett, Kalgutkar, Amit S, Korczynska, Magdalena, Lengyel-Zhand, Zsofia, Gao, Liping, Meredith, Hannah R, Patel, Nandini C, Polivkova, Jana, Rai, Devendra, Rose, Colin R, Rothan, Hussin, Sakata, Sylvie K, Vargo, Thomas R, Qi, Wenying, Wu, Huixian, Liu, Yiping, Yurgelonis, Irina, Zhang, Jinzhi, Zhu, Yuao, Zhang, Lei, Lee, Alpha A

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Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3 von Huard, Kim, Londregan, Allyn T, Tesz, Gregory, Bahnck, Kevin B, Magee, Thomas V, Hepworth, David, Polivkova, Jana, Coffey, Steven B, Pabst, Brandon A, Gosset, James R, Nigam, Anu, Kou, Kou, Sun, Hao, Lee, Kyuha, Herr, Michael, Boehm, Markus, Carpino, Philip A, Goodwin, Bryan, Perreault, Christian, Li, Qifang, Jorgensen, Csilla C, Tkalcevic, George T, Subashi, Timothy A, Ahn, Kay

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Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577 von Smith, Aaron C, Kung, Daniel W, Shavnya, Andre, Brandt, Thomas A, Dent, Philip D, Genung, Nathan E, Cabral, Shawn, Panteleev, Jane, Herr, Michael, Yip, Ka Ning, Aspnes, Gary E, Conn, Edward L, Dowling, Matthew S, Edmonds, David J, Edmonds, Ian D, Fernando, Dilinie P, Herrinton, Paul M, Keene, Nandell F, Lavergne, Sophie Y, Li, Qifang, Polivkova, Jana, Rose, Colin R, Thuma, Benjamin A, Vetelino, Michael G, Wang, Guoqiang, Weaver, John D, Widlicka, Daniel W, Price Wiglesworth, Kristin E, Xiao, Jun, Zahn, Todd, Zhang, Yingxin

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Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor von McClure, Kim F., Jackson, Margaret, Cameron, Kimberly O., Kung, Daniel W., Perry, David A., Orr, Suvi T.M., Zhang, Yingxin, Kohrt, Jeffrey, Tu, Meihua, Gao, Hua, Fernando, Dilinie, Jones, Ryan, Erasga, Noe, Wang, Guoqiang, Polivkova, Jana, Jiao, Wenhua, Swartz, Roger, Ueno, Hirokazu, Bhattacharya, Samit K., Stock, Ingrid A., Varma, Sam, Bagdasarian, Victoria, Perez, Sylvie, Kelly-Sullivan, Dawn, Wang, Ruduan, Kong, Jimmy, Cornelius, Peter, Michael, Laura, Lee, Eunsun, Janssen, Ann, Steyn, Stefanus J., Lapham, Kimberly, Goosen, Theunis

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3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor von Ammirati, Mark J., Andrews, Kim M., Boyer, David D., Brodeur, Anne M., Danley, Dennis E., Doran, Shawn D., Hulin, Bernard, Liu, Shenping, McPherson, R. Kirk, Orena, Stephen J., Parker, Janice C., Polivkova, Jana, Qiu, Xiayang, Soglia, Carolyn B., Treadway, Judith L., VanVolkenburg, Maria A., Wilder, Donald C., Piotrowski, David W.

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Synthesis of 7-Oxo-dihydrospiro[indazole-5,4′-piperidine] Acetyl-CoA Carboxylase Inhibitors von Bagley, Scott W, Southers, James A, Cabral, Shawn, Rose, Colin R, Bernhardson, David J, Edmonds, David J, Polivkova, Jana, Yang, Xiaojing, Kung, Daniel W, Griffith, David A, Bader, Scott J

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Spiroazetidine–piperidine bromoindane as a key modular template to access a variety of compounds via C–C and C–N bond-forming reactions von Fernando, Dilinie P., Jiao, Wenhua, Polivkova, Jana, Xiao, Jun, Coffey, Steven B., Rose, Colin, Londregan, Allyn, Saenz, James, Beveridge, Ramsay, Zhang, Yingxin, Storer, Gregory E., Vrieze, Derek, Erasga, Noe, Jones, Ryan, Khot, Vishal, Cameron, Kimberly O., McClure, Kim F., Bhattacharya, Samit K., Orr, Suvi T.M.

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Synthesis of 7-Oxo-dihydrospiro[indazole-5,4'-piperidinel Acetyl-CoA Carboxylase Inhibitors von BAGLEY, Scott W, SOUTHERS, James A, BADER, Scott J, CABRAL, Shawn, ROSE, Colin R, BERNHARDSON, David J, EDMONDS, David J, POLIVKOVA, Jana, XIAOJING YANG, KUNG, Daniel W, GRIFFITH, David A

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