Mitotane has a strong and a durable inducing effect on CYP3A4 activity von van Erp, Nielka P, Guchelaar, Henk-Jan, Ploeger, Bart A, Romijn, Johannes A, Hartigh, Jan den, Gelderblom, Hans

Volltext

Extensions to the Visual Predictive Check to facilitate model performance evaluation von Post, Teun M., Freijer, Jan I., Ploeger, Bart A., Danhof, Meindert

Volltext

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling von Ploeger, Bart A., van der Graaf, Piet H., Danhof, Meindert

Volltext

Pharmacokinetic-Pharmacodynamic Model for the Reversal of Neuromuscular Blockade by Sugammadex von PLOEGER, Bart A, SMEETS, Jean, STROUGO, Ashley, DRENTH, Henk-Jan, RUIGT, Ge, HOUWING, Natalie, DANHOF, Meindert

Volltext

Exposure–Response Modeling and Simulation of Progression‐Free Survival and Adverse Events of Sorafenib Treatment in Patients With Advanced Thyroid Cancer von Grevel, Joachim, Jentsch, Garrit, Austin, Rupert, Prins, Nicolaas H., Lettieri, John, Mitchell, David, Huang, Funan, Brose, Marcia S., Schlumberger, Martin, Meinhardt, Gerold, Peña, Carol E. A., Ploeger, Bart A.

Volltext

Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar von Stringer, Frances, Ploeger, Bart A., Jongh, Joost De, Scott, Graham, Urquhart, Richard, Karim, Aziz, Danhof, Meindert

Volltext

Population pharmacokinetics of regorafenib in solid tumours: Exposure in clinical practice considering enterohepatic circulation and food intake von Keunecke, Anne, Hoefman, Sven, Drenth, Henk‐Jan, Zisowsky, Jochen, Cleton, Adriaan, Ploeger, Bart A.

Volltext

Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response mod... von Sutter, Gabriele, Frei, Matthias, Schultze‐Mosgau, Marcus‐Hillert, Petersdorf, Kathrin, Seitz, Christian, Ploeger, Bart A.

Volltext

Phase 1 dose-escalation and pharmacokinetic study of regorafenib in paediatric patients with recurrent or refractory solid malignancies von Geoerger, Birgit, Morland, Bruce, Jiménez, Irene, Frappaz, Didier, Pearson, Andrew D.J., Vassal, Gilles, Maeda, Patricia, Kincaide, Jasmine, Mueller, Udo, Schlief, Sarah, Teufel, Michael, Ploeger, Bart A., Cleton, Adriaan, Agostinho, Andrea C., Marshall, Lynley V.

Volltext

Clinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview von Schultze-Mosgau, Marcus-Hillert, Ploeger, Bart A., Frei, Matthias, Höchel, Joachim, Rottmann, Antje

Volltext

Regorafenib plus Vincristine and Irinotecan in Pediatric Patients with Recurrent/Refractory Solid Tumors: An Innovative Therapy for Children with Cancer Study von Casanova, Michela, Bautista, Francisco, Campbell-Hewson, Quentin, Makin, Guy, Marshall, Lynley V., Verschuur, Arnauld C., Cañete Nieto, Adela, Corradini, Nadège, Ploeger, Bart A., Brennan, Barbara J., Mueller, Udo, Zebger-Gong, Hong, Chung, John W., Geoerger, Birgit

Volltext

Changes in GABAA receptor properties in amygdala kindled animals: In vivo studies using [11C]flumazenil and positron emission tomography von Liefaard, Lia C., Ploeger, Bart A., Molthoff, Carla F. M., De Jong, Hugo W. A. M., Dijkstra, Jouke, Van Der Weerd, Louise, Lammertsma, Adriaan A., Danhof, Meindert, Voskuyl, Rob A.

Volltext

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research von Danhof, Meindert, de Lange, Elizabeth C.M, Della Pasqua, Oscar E, Ploeger, Bart A, Voskuyl, Rob A

Volltext

The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives von Bueters, Tjerk, Ploeger, Bart A., Visser, Sandra A.G.

Volltext

Regorafenib plus nivolumab in patients with mismatch repair-proficient/microsatellite stable metastatic colorectal cancer: a single-arm, open-label, multicentre phase 2 study von Fakih, Marwan, Raghav, Kanwal Pratap Singh, Chang, David Z., Larson, Tim, Cohn, Allen L., Huyck, Timothy K., Cosgrove, David, Fiorillo, Joseph A., Tam, Rachel, D'Adamo, David, Sharma, Neelesh, Brennan, Barbara J., Wang, Ying A., Coppieters, Sabine, Zebger-Gong, Hong, Weispfenning, Anke, Seidel, Henrik, Ploeger, Bart A., Mueller, Udo, Oliveira, Carolina Soares Viana de, Paulson, Andrew Scott

Volltext

Model‐Based Dose Selection for Intravaginal Ring Formulations Releasing Anastrozole and Levonorgestrel Intended for the Treatment of Endometriosis Symptoms von Reinecke, Isabel, Schultze‐Mosgau, Marcus‐Hillert, Nave, Rüdiger, Schmitz, Heinz, Ploeger, Bart A.

Volltext

Mechanism-based pharmacokinetic -pharmacodynamic modeling : Biophase distribution, receptor theory, and dynamical systems analysis von DANHOF, Meindert, DE JONGH, Joost, DE LANGE, Elizabeth C. M, PASQUA, Oscar Della, PLOEGER, Bart A, VOSKUYL, Rob A

Volltext

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeli... von Malmborg, Jonas, Ploeger, Bart A.

Volltext

Systemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal Administration von STEVENS, Jasper, PLOEGER, Bart A, VAN DER GRAAF, Piet H, DANHOF, Meindert, DE LANGE, Elizabeth C. M

Volltext

Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation von Snelder, Nelleke, Ploeger, Bart A, Luttringer, Olivier, Stanski, Donald R, Danhof, Meindert

Volltext