Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation von Mendiola, Andrew S., Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M., Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A., Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A., Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J., Machado, Michael R., Bedard, Catherine, Rios Coronado, Pamela E., Jiang, Xiqian, Wang, Jin, Pleiss, Michael A., Green, Ari J., Zamvil, Scott S., Pico, Alexander R., Bruneau, Benoit G., Arkin, Michelle R., Akassoglou, Katerina

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small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model von Tsvetkov, Andrey S, Miller, Jason, Arrasate, Montserrat, Wong, Jinny S, Pleiss, Michael A, Finkbeiner, Steven

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Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models von Barmada, Sami J, Serio, Andrea, Arjun, Arpana, Bilican, Bilada, Daub, Aaron, Ando, D Michael, Tsvetkov, Andrey, Pleiss, Michael, Li, Xingli, Peisach, Daniel, Shaw, Christopher, Chandran, Siddharthan, Finkbeiner, Steven

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Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice von Blasio, Angelo, Wang, Jingyi, Wang, Dan, Varodayan, Florence P., Pomrenze, Matthew B., Miller, Jacklyn, Lee, Anna M., McMahon, Thomas, Gyawali, Sandeep, Wang, Hua-Yu, Roberto, Marisa, McHardy, Stanton, Pleiss, Michael A., Messing, Robert O.

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Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons von Chen, Hung-Kai, Liu, Zhaoping, Meyer-Franke, Anke, Brodbeck, Jens, Miranda, Rene D., McGuire, James G., Pleiss, Michael A., Ji, Zhong-Sheng, Balestra, Maureen E., Walker, David W., Xu, Qin, Jeong, Dah-eun, Budamagunta, Madhu S., Voss, John C., Freedman, Stephen B., Weisgraber, Karl H., Huang, Yadong, Mahley, Robert W.

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Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation von Mendiola, Andrew S., Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M., Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A., Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A., Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J., Machado, Michael R., Bedard, Catherine, Coronado, Pamela E. Rios, Jiang, Xiqian, Wang, Jin, Pleiss, Michael A., Green, Ari J., Zamvil, Scott S., Pico, Alexander R., Bruneau, Benoit G., Arkin, Michelle R., Akassoglou, Katerina

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Prime side chromane-containing inhibitors von Ng, Raymond A., Sun, Minghua, Bowers, Simeon, Hom, Roy K., Probst, Gary D., John, Varghese, Fang, Lawrence Y., Maillard, Michel, Gailunas, Andrea, Brogley, Louis, Neitz, R. Jeffrey, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Adler, Marc, Yao, Nanhua, Zmolek, Wes, Nakamura, David, Quinn, Kevin P., Sauer, John-Michael, Bova, Michael P., Ruslim, Lany, Artis, Dean R., Yednock, Ted A.

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease von Basi, Guriqbal S, Hemphill, Susanna, Brigham, Elizabeth F, Liao, Anna, Aubele, Danielle L, Baker, Jeanne, Barbour, Robin, Bova, Michael, Chen, Xiao-Hua, Dappen, Michael S, Eichenbaum, Tovah, Goldbach, Erich, Hawkinson, Jon, Lawler-Herbold, Rose, Hu, Kang, Hui, Terence, Jagodzinski, Jacek J, Keim, Pamela S, Kholodenko, Dora, Latimer, Lee H, Lee, Mike, Marugg, Jennifer, Mattson, Matthew N, McCauley, Scott, Miller, James L, Motter, Ruth, Mutter, Linda, Neitzel, Martin L, Ni, Huifang, Nguyen, Lan, Quinn, Kevin, Ruslim, Lany, Semko, Christopher M, Shapiro, Paul, Smith, Jenifer, Soriano, Ferdie, Szoke, Balazs, Tanaka, Kevin, Tang, Pearl, Tucker, John A, Ye, Xiacong Michael, Yu, Mei, Wu, Jing, Xu, Ying-Zi, Garofalo, Albert W, Sauer, John Michael, Konradi, Andrei W, Ness, Daniel, Shopp, George, Pleiss, Michael A, Freedman, Stephen B, Schenk, Dale

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Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents von Sealy, Jennifer M., Truong, Anh P., Tso, Luke, Probst, Gary D., Aquino, Jose, Hom, Roy K., Jagodzinska, Barbara M., Dressen, Darren, Wone, David W.G., Brogley, Louis, John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Dappen, Michael S., Toth, Gergely, Pan, Hu, Ruslim, Lany, Miller, Jim, Bova, Michael P., Sinha, Sukanto, Quinn, Kevin P., Sauer, John-Michael

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PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration von Smith, Jenifer L., Rossiter, Kassandra I., Semko, Christopher M., Xu, Ying-Zi, Quincy, David A., Jagodzinski, Jacek, Dappen, Michael S., Konradi, Andrei W., Vandevert, Christopher, Garrido, Caroline, Mao, Wenxian, San Pablo, F. Bong, Wipke, Brian, Dofiles, Lilibeth, Wadsworth, Angie, Peterson, Eric, Lorenzana, Carlos, Simmonds, Stellanie, Messersmith, Elizabeth K., Bard, Frederique, Pleiss, Michael A., Yednock, Ted A.

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Arylsulfonamide pyrimidines as VLA-4 antagonists von Xu, Ying-zi, Konradi, Andrei W., Bard, Frederique, Dappen, Michael, Dofiles, Lilibeth, Dreyer, Mark, Gallager, Ian, Garrido, Caroline, Krimm, Mike, Liao, Zhenmei, Messersmith, Elizabeth, Mutter, Linda, Pleiss, Michael A., Samant, Bhushan, Semko, Christopher M., Smith, Jennifer, Stappenbeck, Frank, Stupi, Brian, Vandervert, Chris, Welch, Brent, Wipke, Brian, Yednock, Ted

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Orally available and efficacious α4β1/α4β7 integrin inhibitors von Xu, Ying-zi, Smith, Jenifer L., Semko, Christopher M., Rossiter, Kassandra I., Fukuda, Juri Y., Dappen, Michael S., Quincy, David A., Konradi, Andrei W., Mao, Wenxian, Welch, Brent, Dreyer, Mark L., Samant, Bhushan, Zhang, Hongbin, Lugar, Judevin, Liao, Zhenmei, Henschel, Carrol, Petersen, Eric, Vandevert, Christopher, Shoemaker, Mark, Wehner, Nancy, Mutter, Linda, Shopp, George, Krimm, Michael, Chen, Linda, Wipke, Brian, Dofiles, Lilibeth, Gallager, Ian, Sauer, John-Michael, Messersmith, Elizabeth K., Pleiss, Michael A., Bard, Frederique, Yednock, Ted A.

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Preparation and Optimization of a Series of 3-Carboxamido-5-phenacylaminopyrazole Bradykinin B1 Receptor Antagonists von Dressen, Darren, Garofalo, Albert W, Hawkinson, Jon, Hom, Dennis, Jagodzinski, Jacek, Marugg, Jennifer L, Neitzel, Martin L, Pleiss, Michael A, Szoke, Balazs, Tung, Jay S, Wone, David W. G, Wu, Jing, Zhang, Heather

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Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: Structure–activity relationship of P2′ substituents von Truong, Anh P., Probst, Gary D., Aquino, Jose, Fang, Larry, Brogley, Louis, Sealy, Jennifer M., Hom, Roy K., Tucker, John A., John, Varghese, Tung, Jay S., Pleiss, Michael A., Konradi, Andrei W., Sham, Hing L., Dappen, Michael S., Tóth, Gergley, Yao, Nanhua, Brecht, Eric, Pan, Hu, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region von Probst, Gary D., Bowers, Simeon, Sealy, Jennifer M., Stupi, Brian, Dressen, Darren, Jagodzinska, Barbara M., Aquino, Jose, Gailunas, Andrea, Truong, Anh P., Tso, Luke, Xu, Ying-Zi, Hom, Roy K., John, Varghese, Tung, Jay S., Pleiss, Michael A., Tucker, John A., Konradi, Andrei W., Sham, Hing L., Jagodzinski, Jacek, Toth, Gergely, Brecht, Eric, Yao, Nanhua, Pan, Hu, Lin, May, Artis, Dean R., Ruslim, Lany, Bova, Michael P., Sinha, Sukanto, Yednock, Ted A., Gauby, Shawn, Zmolek, Wes, Quinn, Kevin P., Sauer, John-Michael

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Discovery of sulfonamide–pyrazole γ-secretase inhibitors von Mattson, Matthew N., Neitzel, Martin L., Quincy, David A., Semko, Christopher M., Garofalo, Albert W., Keim, Pamela S., Konradi, Andrei W., Pleiss, Michael A., Sham, Hing L., Brigham, Elizabeth F., Goldbach, Erich G., Zhang, Hongbin, Sauer, John-Michael, Basi, Guriqbal S.

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Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer’s disease von Neitzel, Martin L., Aubele, Danielle L., Marugg, Jennifer L., Jagodzinski, Jacek J., Konradi, Andrei W., Pleiss, Michael A., Szoke, Balazs, Zmolek, Wes, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Brigham, Elizabeth F., Wallace, William, Bova, Michael P., Hemphill, Susanna, Basi, Guriqbal

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Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis von Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas JC, Shea, Lonnie D, Miller, Stephen D

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Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model von Semko, Christopher M., Chen, Linda, Dressen, Darren B., Dreyer, Mark L., Dunn, Whitney, Farouz, Francine S., Freedman, Stephen B., Holsztynska, Elizabeth J., Jefferies, Michael, Konradi, Andrei W., Liao, Anna, Lugar, Judevin, Mutter, Linda, Pleiss, Michael A., Quinn, Kevin P., Thompson, Thomas, Thorsett, Eugene D., Vandevert, Christopher, Xu, Ying-Zi, Yednock, Ted A.

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Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation (Apri, 10.1038/s41590-020-0654-0, 2020) von Mendiola, Andrew S., Ryu, Jae Kyu, Bardehle, Sophia, Meyer-Franke, Anke, Ang, Kenny Kean-Hooi, Wilson, Chris, Baeten, Kim M., Hanspers, Kristina, Merlini, Mario, Thomas, Sean, Petersen, Mark A., Williams, Alexander, Thomas, Reuben, Rafalski, Victoria A., Meza-Acevedo, Rosa, Tognatta, Reshmi, Yan, Zhaoqi, Pfaff, Samuel J., Machado, Michael R., Bedard, Catherine, Coronado, Pamela E. Rios, Jiang, Xiqian, Wang, Jin, Pleiss, Michael A., Green, Ari J., Zamvil, Scott S., Pico, Alexander R., Bruneau, Benoit G., Arkin, Michelle R., Akassoglou, Katerina

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