Cell Adhesion Mechanisms in Platelets von Varga-Szabo, David, Pleines, Irina, Nieswandt, Bernhard

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Factor XIIa Inhibitor Recombinant Human Albumin Infestin-4 Abolishes Occlusive Arterial Thrombus Formation Without Affecting Bleeding von HAGEDORN, Ina, SCHMIDBAUER, Stefan, PLEINES, Irina, KLEINSCHNITZ, Christoph, KRONTHALER, Ulrich, STOLL, Guido, DICKNEITE, Gerhard, NIESWANDT, Bernhard

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Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation von Braun, Attila, Varga-Szabo, David, Kleinschnitz, Christoph, Pleines, Irina, Bender, Markus, Austinat, Madeleine, Bösl, Michael, Stoll, Guido, Nieswandt, Bernhard

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CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis von May, Frauke, Hagedorn, Ina, Pleines, Irina, Bender, Markus, Vögtle, Timo, Eble, Johannes, Elvers, Margitta, Nieswandt, Bernhard

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Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis von Pleines, Irina, Hagedorn, Ina, Gupta, Shuchi, May, Frauke, Chakarova, Lidija, van Hengel, Jolanda, Offermanns, Stefan, Krohne, Georg, Kleinschnitz, Christoph, Brakebusch, Cord, Nieswandt, Bernhard

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Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42 von Pleines, Irina, Dütting, Sebastian, Cherpokova, Deya, Eckly, Anita, Meyer, Imke, Morowski, Martina, Krohne, Georg, Schulze, Harald, Gachet, Christian, Debili, Najet, Brakebusch, Cord, Nieswandt, Bernhard

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Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo von Nieswandt, Bernhard, Moser, Markus, Pleines, Irina, Varga-Szabo, David, Monkley, Sue, Critchley, David, Fässler, Reinhard

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The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction von Varga-Szabo, David, Braun, Attila, Kleinschnitz, Christoph, Bender, Markus, Pleines, Irina, Pham, Mirko, Renné, Thomas, Stoll, Guido, Nieswandt, Bernhard

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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis von Dütting, Sebastian, Gaits-Iacovoni, Frederique, Stegner, David, Popp, Michael, Antkowiak, Adrien, van Eeuwijk, Judith M.M., Nurden, Paquita, Stritt, Simon, Heib, Tobias, Aurbach, Katja, Angay, Oguzhan, Cherpokova, Deya, Heinz, Niels, Baig, Ayesha A., Gorelashvili, Maximilian G., Gerner, Frank, Heinze, Katrin G., Ware, Jerry, Krohne, Georg, Ruggeri, Zaverio M., Nurden, Alan T., Schulze, Harald, Modlich, Ute, Pleines, Irina, Brakebusch, Cord, Nieswandt, Bernhard

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Coactosin-like 1 integrates signaling critical for shear-dependent thrombus formation in mouse platelets von Scheller, Inga, Stritt, Simon, Beck, Sarah, Peng, Bing, Pleines, Irina, Heinze, Katrin G., Braun, Attila, Otto, Oliver, Ahrends, Robert, Sickmann, Albert, Bender, Markus, Nieswandt, Bernhard

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Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets von Pleines, Irina, Eckly, Anita, Elvers, Margitta, Hagedorn, Ina, Eliautou, Sandra, Bender, Markus, Wu, Xunwei, Lanza, Francois, Gachet, Christian, Brakebusch, Cord, Nieswandt, Bernhard

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Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan von Liu, Zhi-Jian, Hoffmeister, Karin M., Hu, Zhongbo, Mager, Donald E., Ait-Oudhia, Sihem, Debrincat, Marlyse A., Pleines, Irina, Josefsson, Emma C., Kile, Benjamin T., Italiano, Joseph, Ramsey, Haley, Grozovsky, Renata, Veng-Pedersen, Peter, Chavda, Chaitanya, Sola-Visner, Martha

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Rac1 is essential for phospholipase C-γ2 activation in platelets von Pleines, Irina, Elvers, Margitta, Strehl, Amrei, Pozgajova, Miroslava, Varga-Szabo, David, May, Frauke, Chrostek-Grashoff, Anna, Brakebusch, Cord, Nieswandt, Bernhard

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ADF/n-cofilin–dependent actin turnover determines platelet formation and sizing von Bender, Markus, Eckly, Anita, Hartwig, John H., Elvers, Margitta, Pleines, Irina, Gupta, Shuchi, Krohne, Georg, Jeanclos, Elisabeth, Gohla, Antje, Gurniak, Christine, Gachet, Christian, Witke, Walter, Nieswandt, Bernhard

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Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function von Schröder, Jenny, Lüllmann-Rauch, Renate, Himmerkus, Nina, Pleines, Irina, Nieswandt, Bernhard, Orinska, Zane, Koch-Nolte, Friedrich, Schröder, Bernd, Bleich, Markus, Saftig, Paul

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An essential role for α4A-tubulin in platelet biogenesis von Strassel, Catherine, Magiera, Maria M, Dupuis, Arnaud, Batzenschlager, Morgane, Hovasse, Agnès, Pleines, Irina, Guéguen, Paul, Eckly, Anita, Moog, Sylvie, Mallo, Léa, Kimmerlin, Quentin, Chappaz, Stéphane, Strub, Jean-Marc, Kathiresan, Natarajan, de la Salle, Henri, Van Dorsselaer, Alain, Ferec, Claude, Py, Jean-Yves, Gachet, Christian, Schaeffer-Reiss, Christine, Kile, Benjamin T, Janke, Carsten, Lanza, François

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RhoA/ROCK guides NMII on the way to MK polyploidy von Pleines, Irina, Nieswandt, Bernhard

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Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis von Nagy, Magdolna, van Geffen, Johanna P, Stegner, David, Adams, David J, Braun, Attila, de Witt, Susanne M, Elvers, Margitta, Geer, Mitchell J, Kuijpers, Marijke J E, Kunzelmann, Karl, Mori, Jun, Oury, Cécile, Pircher, Joachim, Pleines, Irina, Poole, Alastair W, Senis, Yotis A, Verdoold, Remco, Weber, Christian, Nieswandt, Bernhard, Heemskerk, Johan W M, Baaten, Constance C F M J

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Interleukin-11 Is the Dominant IL-6 Family Cytokine during Gastrointestinal Tumorigenesis and Can Be Targeted Therapeutically von Putoczki, Tracy L., Thiem, Stefan, Loving, Andrea, Busuttil, Rita A., Wilson, Nicholas J., Ziegler, Paul K., Nguyen, Paul M., Preaudet, Adele, Farid, Ryan, Edwards, Kirsten M., Boglev, Yeliz, Luwor, Rodney B., Jarnicki, Andrew, Horst, David, Boussioutas, Alex, Heath, Joan K., Sieber, Oliver M., Pleines, Irina, Kile, Benjamin T., Nash, Andrew, Greten, Florian R., McKenzie, Brent S., Ernst, Matthias

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Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion von Stahnke, Stephanie, Döring, Hermann, Kusch, Charly, de Gorter, David J.J., Dütting, Sebastian, Guledani, Aleks, Pleines, Irina, Schnoor, Michael, Sixt, Michael, Geffers, Robert, Rohde, Manfred, Müsken, Mathias, Kage, Frieda, Steffen, Anika, Faix, Jan, Nieswandt, Bernhard, Rottner, Klemens, Stradal, Theresia E.B.

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