Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530 von Green, Tim P., Fennell, Mike, Whittaker, Robin, Curwen, Jon, Jacobs, Vivien, Allen, Jack, Logie, Armelle, Hargreaves, Judith, Hickinson, D. Mark, Wilkinson, Robert W., Elvin, Paul, Boyer, Brigitte, Carragher, Neil, Plé, Patrick A., Bermingham, Alun, Holdgate, Geoffrey A., Ward, Walter H.J., Hennequin, Laurent F., Davies, Barry R., Costello, Gerard F.

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N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specifi... von Hennequin, Laurent F, Allen, Jack, Breed, Jason, Curwen, Jon, Fennell, Michael, Green, Tim P, Lambert-van der Brempt, Christine, Morgentin, Rémy, Norman, Richard A, Olivier, Annie, Otterbein, Ludovic, Plé, Patrick A, Warin, Nicolas, Costello, Gerard

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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases von Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian

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Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators von Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S

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Discovery of a New Class of Anilinoquinazoline Inhibitors with High Affinity and Specificity for the Tyrosine Kinase Domain of c-Src von Plé, Patrick A, Green, Tim P, Hennequin, Laurent F, Curwen, Jon, Fennell, Michael, Allen, Jack, Lambert-van der Brempt, Christine, Costello, Gerard

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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains:  Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase Inhibitors von Hennequin, Laurent F, Stokes, Elaine S. E, Thomas, Andrew P, Johnstone, Craig, Plé, Patrick A, Ogilvie, Donald J, Dukes, Michael, Wedge, Stephen R, Kendrew, Jane, Curwen, Jon O

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Discovery of new quinoline ether inhibitors with high affinity and selectivity for PDGFR tyrosine kinases von Plé, Patrick A., Jung, Frédéric, Ashton, Sue, Hennequin, Laurent, Laine, Romuald, Lambert-van der Brempt, Christine, Morgentin, Rémy, Pasquet, Georges, Taylor, Sian

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New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors von Barlaam, Bernard, Fennell, Mike, Germain, Hervé, Green, Tim, Hennequin, Laurent, Morgentin, Rémy, Olivier, Annie, Plé, Patrick, Vautier, Michel, Costello, Gerard

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Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Giordanetto, Fabrizio, Green, Stephen, Inghardt, Tord, Hennequin, Laurent, Hancox, Urs, Lambert-van der Brempt, Christine, Morgentin, Rémy, Pass, Sarah, Plé, Patrick, Saleh, Twana, Ward, Lara

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Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Ellston, Rebecca, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Plé, Patrick, Ward, Lara, Warin, Nicolas

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Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators von Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S

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Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Péru, Aurélien, Plé, Patrick, Saleh, Twana, Ward, Lara, Warin, Nicolas

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Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors von Hennequin, Laurent F, Thomas, Andrew P, Johnstone, Craig, Stokes, Elaine S. E, Plé, Patrick A, Lohmann, Jean-Jacques M, Ogilvie, Donald J, Dukes, Mike, Wedge, Steve R, Curwen, Jon O, Kendrew, Jane, Lambert-van der Brempt, Christine

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Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series von Barlaam, Bernard, Ducray, Richard, Brempt, Christine Lambert-van der, Plé, Patrick, Bardelle, Catherine, Brooks, Nigel, Coleman, Tanya, Cross, Darren, Kettle, Jason G., Read, Jon

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Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones von Morgentin, Rémy, Pasquet, Georges, Boutron, Pascal, Jung, Frédéric, Lamorlette, Maryannick, Maudet, Mickaël, Plé, Patrick

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An efficient large-scale synthesis of alkyl 5-hydroxy-pyridin- and pyrimidin-2-yl acetate von Morgentin, Rémy, Jung, Frédéric, Lamorlette, Maryannick, Maudet, Mickaël, Ménard, Morgan, Plé, Patrick, Pasquet, Georges, Renaud, Fabrice

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Discovery of (R)‑8-(1-(3,5-Difluorophenylamino)ethyl)‑N,N‑dimethyl-2-morpholino-4-oxo‑4H‑chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for t... von Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Pasquet, Marie-Jeanne, Péru, Aurélien, Plé, Patrick, Saleh, Twana, Vautier, Michel, Walker, Mike, Ward, Lara, Warin, Nicolas

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An efficient large-scale synthesis of alkyl 5-hydroxy-pyridinand pyrimidin-2-yl acetate von MORGENTIN, Rémy, JUNG, Frédéric, LAMORLETTE, Maryannick, MAUDET, Mickaël, MENARD, Morgan, PLE, Patrick, PASQUET, Georges, RENAUD, Fabrice

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