proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates von Chan, Joyce C.Y, Piper, Derek E, Cao, Qiong, Liu, Dongming, King, Chadwick, Wang, Wei, Tang, Jie, Liu, Qiang, Higbee, Jared, Xia, Zhen, Di, Yongmei, Shetterly, Susan, Arimura, Ziva, Salomonis, Heather, Romanow, William G, Thibault, Stephen T, Zhang, Richard, Cao, Ping, Yang, Xiao-Ping, Yu, Timothy, Lu, Mei, Retter, Marc W, Kwon, Gayle, Henne, Kirk, Pan, Oscar, Tsai, Mei-Mei, Fuchslocher, Bryna, Yang, Evelyn, Zhou, Lei, Lee, Ki Jeong, Daris, Mark, Sheng, Jackie, Wang, Yan, Shen, Wenyan D, Yeh, Wen-Chen, Emery, Maurice, Walker, Nigel P.C, Shan, Bei, Schwarz, Margrit, Jackson, Simon M

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The Crystal Structure of PCSK9: A Regulator of Plasma LDL-Cholesterol von Piper, Derek E., Jackson, Simon, Liu, Qiang, Romanow, William G., Shetterly, Susan, Thibault, Stephen T., Shan, Bei, Walker, Nigel P.C.

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Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers von Herter, Sylvia, Piper, Derek E, Aaron, Wade, Gabriele, Timothy, Cutler, Gene, Cao, Ping, Bhatt, Ami S, Choe, Youngchool, Craik, Charles S, Walker, Nigel, Meininger, David, Hoey, Timothy, Austin, Richard J

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The high-resolution crystal structure of human LCAT von Piper, Derek E, Romanow, William G, Gunawardane, Ruwanthi N, Fordstrom, Preston, Masterman, Stephanie, Pan, Oscar, Thibault, Stephen T, Zhang, Richard, Meininger, David, Schwarz, Margrit, Wang, Zhulun, King, Chadwick, Zhou, Mingyue, Walker, Nigel P C

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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to... von Henne, Kirk R, Ason, Brandon, Howard, Monique, Wang, Wei, Sun, Jeonghoon, Higbee, Jared, Tang, Jie, Matsuda, Katherine C, Xu, Ren, Zhou, Lei, Chan, Joyce C Y, King, Chadwick, Piper, Derek E, Ketchem, Randal R, Michaels, Mark Leo, Jackson, Simon M, Retter, Marc W

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Molecular basis of PCSK9 function von Lambert, Gilles, Charlton, Francesca, Rye, Kerry-Anne, Piper, Derek E

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Discovery and optimization of a series of liver X receptor antagonists von Jiao, XianYun, Kopecky, David J., Fisher, Ben, Piper, Derek E., Labelle, Marc, McKendry, Sharon, Harrison, Martin, Jones, Stuart, Jaen, Juan, Shiau, Andrew K., Escaron, Patrick, Danao, Jean, Chai, Anne, Coward, Peter, Kayser, Frank

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Discovery of a new binding mode for a series of liver X receptor agonists von Kopecky, David J., Jiao, Xian Yun, Fisher, Ben, McKendry, Sharon, Labelle, Marc, Piper, Derek E., Coward, Peter, Shiau, Andrew K., Escaron, Patrick, Danao, Jean, Chai, Anne, Jaen, Juan, Kayser, Frank

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Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model von Hu, Essa, Hong, Fang-Tsao, Aral, Jennifer, Long, Jason, Piper, Derek E, Poppe, Leszek, Andrews, Kristin L, Hager, Todd, Davis, Carl, Li, Hongyan, Wong, Philip, Gavva, Narender, Shi, Licheng, Zhu, Dawn X. D, Lehto, Sonya G, Xu, Cen, Miranda, Les P

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Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism von Gunawardane, Ruwanthi N., Fordstrom, Preston, Piper, Derek E., Masterman, Stephanie, Siu, Sophia, Liu, Dongming, Brown, Mike, Lu, Mei, Tang, Jie, Zhang, Richard, Cheng, Janet, Gates, Andrew, Meininger, David, Chan, Joyce, Carlson, Tim, Walker, Nigel, Schwarz, Margrit, Delaney, John, Zhou, Mingyue

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The high-resolution crystal structure of human LCAT1 von Piper, Derek E., Romanow, William G., Gunawardane, Ruwanthi N., Fordstrom, Preston, Masterman, Stephanie, Pan, Oscar, Thibault, Stephen T., Zhang, Richard, Meininger, David, Schwarz, Margrit, Wang, Zhulun, King, Chadwick, Zhou, Mingyue, Walker, NigelP.C.

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Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3 von Li, Zhihong, Wang, Xianghong, Eksterowicz, John, Gribble, Michael W, Alba, Grace Q, Ayres, Merrill, Carlson, Timothy J, Chen, Ada, Chen, Xiaoqi, Cho, Robert, Connors, Richard V, DeGraffenreid, Michael, Deignan, Jeffrey T, Duquette, Jason, Fan, Pingchen, Fisher, Benjamin, Fu, Jiasheng, Huard, Justin N, Kaizerman, Jacob, Keegan, Kathleen S, Li, Cong, Li, Kexue, Li, Yunxiao, Liang, Lingming, Liu, Wen, Lively, Sarah E, Lo, Mei-Chu, Ma, Ji, McMinn, Dustin L, Mihalic, Jeffrey T, Modi, Kriti, Ngo, Rachel, Pattabiraman, Kanaka, Piper, Derek E, Queva, Christophe, Ragains, Mark L, Suchomel, Julia, Thibault, Steve, Walker, Nigel, Wang, Xiaodong, Wang, Zhulun, Wanska, Malgorzata, Wehn, Paul M, Weidner, Margaret F, Zhang, Alex J, Zhao, Xiaoning, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang, McGee, Lawrence R, Medina, Julio C

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SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase von Powers, Jay P, Piper, Derek E, Li, Yang, Mayorga, Veronica, Anzola, John, Chen, James M, Jaen, Juan C, Lee, Gary, Liu, Jinqian, Peterson, M. Greg, Tonn, George R, Ye, Qiuping, Walker, Nigel P. C, Wang, Zhulun

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BacMam production of active recombinant lecithin–cholesterol acyltransferase: Expression, purification and characterization von Romanow, William G., Piper, Derek E., Fordstrom, Preston, Thibault, Stephen, Zhou, Mingyue, Walker, Nigel P.C.

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Novel Inhibitors of Hepatitis C Virus RNA-dependent RNA Polymerases von Lee, Gary, Piper, Derek E., Wang, Zhulun, Anzola, John, Powers, Jay, Walker, Nigel, Li, Yang

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Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA: Role of the Hexapeptide and a Fourth Homeodomain Helix in Complex Formation von Piper, Derek E., Batchelor, Adrian H., Chang, Ching-Pin, Cleary, Michael L., Wolberger, Cynthia

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The Structure of GABPα/β: An ETS Domain-Ankyrin Repeat Heterodimer Bound to DNA von Batchelor, Adrian H., Piper, Derek E., de la Brousse, Fabienne Charles, McKnight, Steven L., Wolberger, Cynthia

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Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA von Piper, Derek E., Batchelor, Adrian H., Chang, Ching-Pin, Cleary, Michael L., Wolberger, Cynthia

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MAGEB2 BINDING CONSTRUCTS von PIPER Derek E, MUENZ Markus, TARBELL Kristin, STERNJAK Alexander, SCHUSTER Heiko, CHEN Weihsu Claire, BROZY Johannes, GAEDTKE Lars, RAUM Tobias, D''ANGELO Igor, FOLTZ Ian Nevin, MUKUND Susmith

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PROTEÍNAS DE UNIÓN A ANTÍGENOS DE IL-23 HUMANA von ZHANG, YU, TOWNE, JENNIFER E, KET, RANDAL R, PIPER, DEREK E, CHENG, JANET D, CERNE, HEATHER, SUN, YU, ONEILL, JASON C

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