The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2 von BLACKIE, Josie A, BLOOMER, Jackie C, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, BROWN, Murray J. B, CHENG, Hung-Yuan, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H

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Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs von Young, Robert J., Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chan, Chuen, Charbaut, Marie, Chung, Chun-wa, Convery, Máire A., Kelly, Henry A., Paul King, N., Kleanthous, Savvas, Mason, Andrew M., Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Weston, Helen E.

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The synthesis of 5-alkoxy and 5-amino substituted thiophenes von Pinto, Ivan L, Jarvest, Richard L, Serafinowska, Halina T

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Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs von Kleanthous, Savvas, Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chaudry, Laiq, Chan, Chuen, Clarte, Marie-Olive, Convery, Máire A., Harling, John D., Hortense, Eric, Irving, Wendy R., Irvine, Stephanie, Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Roethka, Theresa J., Senger, Stefan, Shah, Gita P., Stelman, Gary J., Toomey, John R., Watson, Nigel S., West, Robert I., Whittaker, Caroline, Zhou, Ping, Young, Robert J.

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Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs von Young, Robert J., Borthwick, Alan D., Brown, David, Burns-Kurtis, Cynthia L., Campbell, Matthew, Chan, Chuen, Charbaut, Marie, Convery, Máire A., Diallo, Hawa, Hortense, Eric, Irving, Wendy R., Kelly, Henry A., King, N. Paul, Kleanthous, Savvas, Mason, Andrew M., Pateman, Anthony J., Patikis, Angela N., Pinto, Ivan L., Pollard, Derek R., Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Weston, Helen E., Zhou, Ping

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Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones von Jarvest, Richard L., Pinto, Ivan L., Ashman, Stephen M., Dabrowski, Christine E., Fernandez, Annabellee V., Jennings, L.John, Lavery, Patrick, Tew, David G.

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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man von BLACKIE, Josie A, BLOOMER, Jackie C, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, BROWN, Murray J. B, CHENG, Hung-Yuan, ELLIOTT, Richard L, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann

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Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis von Buckle, Derek R, Arch, Jonathon R. S, Fenwick, Ashley E, Houge-Frydrych, Catherine S. V, Pinto, Ivan L, Smith, David G, Taylor, Stephen G, Tedder, John M

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Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514 von PINTO, I. L, BOYD, H. F, HICKEY, D. M. B

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones von BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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Novel, selective mechanism-based inhibitors of the herpes proteases von Pinto, Ivan L., West, Andrew, Debouck, Christine M., DiLella, Anthony G., Gorniak, Joselina G., O'Donnell, Kevin C., O'Shannessy, Daniel J., Patel, Arunbai, Jarvest, Richard L.

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Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols von Buckle, Derek R, Arch, Jonathan R. S, Edge, Colin, Foster, Keith A, Houge-Frydrych, Catherine S. V, Pinto, Ivan L, Smith, David G, Taylor, John F, Taylor, Stephen G

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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 von BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2 von BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 von BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A

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Conformational and steric modifications of the pyran ring of the potassium-channel activator cromakalim von BUCKLE, D. R, EGGLESTON, D. S, HOUGE-FRYDRYCH, C. S. V, PINTO, I. L, READSHAW, S. A, SMITH, D. G, WEBSTER, R. A. B

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Structural modifications of the potassium channel activator cromakalim : the C-3 position von BUCKLE, D. R, HOUGE-FRYDRYCH, C. S. V, PINTO, I. L, SMITH, D. G, TEDDER, J. M

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Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogs in guinea pig trachealis von Arch, Jonathan R. S, Buckle, Derek R, Carey, Claire, Parr-Dobrzanski, Hilary, Faller, Andrew, Foster, Keith A, Houge-Frydrych, Catherine S. V, Pinto, Ivan L, Smith, David G, Taylor, Stephen G

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones von Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M

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Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism von Pinto, Ivan L., Jarvest, Richard L., Clarke, Brian, Dabrowski, Christine E., Fenwick, Ashley, Gorczyca, Michele M, Jennings, L.John, Lavery, Patrick, Sternberg, Edmund J, Tew, David G., West, Andrew

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