Precision is essential for efficient catalysis in an evolved Kemp eliminase von Blomberg, Rebecca, Kries, Hajo, Pinkas, Daniel M., Mittl, Peer R. E., Grütter, Markus G., Privett, Heidi K., Mayo, Stephen L., Hilvert, Donald

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Transglutaminase 2 undergoes a large conformational change upon activation von Pinkas, Daniel M, Strop, Pavel, Brunger, Axel T, Khosla, Chaitan

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Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases von Pinkas, Daniel M, Sanvitale, Caroline E, Bufton, Joshua C, Sorrell, Fiona J, Solcan, Nicolae, Chalk, Rod, Doutch, James, Bullock, Alex N

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The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms von Fulcher, Luke J, Bozatzi, Polyxeni, Tachie-Menson, Theresa, Wu, Kevin Z L, Cummins, Timothy D, Bufton, Joshua C, Pinkas, Daniel M, Dunbar, Karen, Shrestha, Sabin, Wood, Nicola T, Weidlich, Simone, Macartney, Thomas J, Varghese, Joby, Gourlay, Robert, Campbell, David G, Dingwell, Kevin S, Smith, James C, Bullock, Alex N, Sapkota, Gopal P

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Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold von Suebsuwong, Chalada, Dai, Bing, Pinkas, Daniel M., Duddupudi, Anantha Lakshmi, Li, Li, Bufton, Joshua C., Schlicher, Lisa, Gyrd-Hansen, Mads, Hu, Ming, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.

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Redox Regulation of Transglutaminase 2 Activity von Stamnaes, Jorunn, Pinkas, Daniel M., Fleckenstein, Burkhard, Khosla, Chaitan, Sollid, Ludvig M.

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A BTB extension and ion-binding domain contribute to the pentameric structure and TFAP2A binding of KCTD1 von Pinkas, Daniel M., Bufton, Joshua C., Hunt, Alice E., Manning, Charlotte E., Richardson, William, Bullock, Alex N.

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2-Amino-2,3-dihydro-1 H -indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy von Zhu, Dongsheng, Huang, Huocong, Pinkas, Daniel M, Luo, Jinfeng, Ganguly, Debolina, Fox, Alice E, Arner, Emily, Xiang, Qiuping, Tu, Zheng-Chao, Bullock, Alex N, Brekken, Rolf A, Ding, Ke, Lu, Xiaoyun

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2‑Amino-2,3-dihydro‑1H‑indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy von Zhu, Dongsheng, Huang, Huocong, Pinkas, Daniel M, Luo, Jinfeng, Ganguly, Debolina, Fox, Alice E, Arner, Emily, Xiang, Qiuping, Tu, Zheng-Chao, Bullock, Alex N, Brekken, Rolf A, Ding, Ke, Lu, Xiaoyun

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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling von Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads

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Contribution of Oxyanion Stabilization to Kemp Eliminase Efficiency von Kries, Hajo, Bloch, Joël S, Bunzel, H. Adrian, Pinkas, Daniel M, Hilvert, Donald

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Design, Synthesis, and Biological Evaluation of 3‑(Imidazo[1,2‑a]pyrazin-3-ylethynyl)-4-isopropyl‑N‑(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dua... von Wang, Zhen, Zhang, Yali, Pinkas, Daniel M, Fox, Alice E, Luo, Jinfeng, Huang, Huocong, Cui, Shengyang, Xiang, Qiuping, Xu, Tingting, Xun, Qiuju, Zhu, Dongsheng, Tu, Zhengchao, Ren, Xiaomei, Brekken, Rolf A, Bullock, Alex N, Liang, Guang, Ding, Ke, Lu, Xiaoyun

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Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe von Röhm, Sandra, Berger, Benedict-Tilman, Schröder, Martin, Chatterjee, Deep, Mathea, Sebastian, Joerger, Andreas C, Pinkas, Daniel M, Bufton, Joshua C, Tjaden, Amelie, Kovooru, Lohitesh, Kudolo, Mark, Pohl, Christian, Bullock, Alex N, Müller, Susanne, Laufer, Stefan, Knapp, Stefan

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Modular enzymatically crosslinked protein polymer hydrogels for in situ gelation von Davis, Nicolynn E, Ding, Sheng, Forster, Ryan E, Pinkas, Daniel M, Barron, Annelise E

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Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors von Suebsuwong, Chalada, Pinkas, Daniel M., Ray, Soumya S., Bufton, Joshua C., Dai, Bing, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.

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Tunable, Post-translational Hydroxylation of Collagen Domains in Escherichia coli von Pinkas, Daniel M, Ding, Sheng, Raines, Ronald T, Barron, Annelise E

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Active Site Plasticity of a Computationally Designed Retro-Aldolase Enzyme von Obexer, Richard, Studer, Sabine, Giger, Lars, Pinkas, Daniel M., Grütter, Markus G., Baker, David, Hilvert, Donald

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Synthesis and Assembly of Functional High Molecular Weight Adiponectin Multimers in an Engineered Strain of Escherichia coli von Ding, Sheng, Pinkas, Daniel M, Barron, Annelise E

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Small molecule inhibitors reveal an indispensable scaffolding role of RIPK 2 in NOD 2 signaling von Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads

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Precision is essential for efficient catalysis in an evolved Kemp eliminase von Blomberg, Rebecca, Kries, Hajo, Pinkas, Daniel M, Mittl, Peer R E, Grütter, Markus G, Privett, Heidi K, Mayo, Stephen L, Hilvert, Donald

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