The LEAP program: lenvatinib plus pembrolizumab for the treatment of advanced solid tumors von Taylor, Matthew H, Schmidt, Emmett V, Dutcus, Corina, Pinheiro, Elaine M, Funahashi, Yasuhiro, Lubiniecki, Gregory, Rasco, Drew

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Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice von Klapproth, Sarah, Sperandio, Markus, Pinheiro, Elaine M., Prünster, Monika, Soehnlein, Oliver, Gertler, Frank B., Fässler, Reinhard, Moser, Markus

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Rap1 and its effector RIAM are required for lymphocyte trafficking von Su, Wenjuan, Wynne, Joseph, Pinheiro, Elaine M., Strazza, Marianne, Mor, Adam, Montenont, Emilie, Berger, Jeffrey, Paul, David S., Bergmeier, Wolfgang, Gertler, Frank B., Philips, Mark R.

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Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma von Pham, Christina D, Flores, Catherine, Yang, Changlin, Pinheiro, Elaine M, Yearley, Jennifer H, Sayour, Elias J, Pei, Yanxin, Moore, Colin, McLendon, Roger E, Huang, Jianping, Sampson, John H, Wechsler-Reya, Robert, Mitchell, Duane A

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Assessment of Clinical Activity of PD-1 Checkpoint Inhibitor Combination Therapies Reported in Clinical Trials von Schmidt, Emmett V, Chisamore, Michael J, Chaney, Marya F, Maradeo, Marie E, Anderson, James, Baltus, Gretchen A, Pinheiro, Elaine M, Uebele, Victor N

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Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy von Raghavan, Sukanya, Tovbis-Shifrin, Nataliya, Kochel, Christina, Sawant, Anandi, Mello, Marielle, Sathe, Manjiri, Blumenschein, Wendy, Muise, Eric S, Chackerian, Alissa, Pinheiro, Elaine M, Rosahl, Thomas W, Luche, Hervé, de Waal Malefyt, Rene

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Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression von Hossain, Dewan Md Sakib, Javaid, Sarah, Cai, Mingmei, Zhang, Chunsheng, Sawant, Anandi, Hinton, Marlene, Sathe, Manjiri, Grein, Jeff, Blumenschein, Wendy, Pinheiro, Elaine M, Chackerian, Alissa

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Requirement for Par-6 and Bazooka in Drosophila border cell migration von Pinheiro, Elaine M, Montell, Denise J

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PVF1, a PDGF/VEGF homolog, is sufficient to guide border cells and interacts genetically with Taiman von McDonald, Jocelyn A, Pinheiro, Elaine M, Montell, Denise J

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Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors von Morris, Erick J, Jha, Sharda, Restaino, Clifford R, Dayananth, Priya, Zhu, Hugh, Cooper, Alan, Carr, Donna, Deng, Yongi, Jin, Weihong, Black, Stuart, Long, Brian, Liu, Jenny, Dinunzio, Edward, Windsor, William, Zhang, Rumin, Zhao, Shuxia, Angagaw, Minilik H, Pinheiro, Elaine M, Desai, Jagdish, Xiao, Li, Shipps, Gerald, Hruza, Alan, Wang, James, Kelly, Joe, Paliwal, Sunil, Gao, Xiaolei, Babu, Boga Sobhana, Zhu, Liang, Daublain, Pierre, Zhang, Ling, Lutterbach, Bart A, Pelletier, Marc R, Philippar, Ulrike, Siliphaivanh, Phieng, Witter, David, Kirschmeier, Paul, Bishop, W Robert, Hicklin, Daniel, Gilliland, D Gary, Jayaraman, Lata, Zawel, Leigh, Fawell, Stephen, Samatar, Ahmed A

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Toward a CRISPR-based mouse model of Vhl -deficient clear cell kidney cancer: Initial experience and lessons learned von Stransky, Laura A, Gao, Wenhua, Schmidt, Laura S, Bi, Kevin, Ricketts, Christopher J, Ramesh, Vijyendra, James, Amy, Difilippantonio, Simone, Ileva, Lilia, Kalen, Joseph D, Karim, Baktiar, Jeon, Albert, Morgan, Tamara, Warner, Andrew C, Turan, Sevilay, Unite, Joanne, Tran, Bao, Choudhari, Sulbha, Zhao, Yongmei, Linn, Douglas E, Yun, Changhong, Dhandapani, Sripriya, Parab, Vaishali, Pinheiro, Elaine M, Morris, Nicole, He, Lixia, Vigeant, Sean M, Pignon, Jean-Christophe, Sticco-Ivins, Maura, Signoretti, Sabina, Van Allen, Eliezer M, Linehan, W Marston, Kaelin, Jr, William G

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Reverse Translating Molecular Determinants of Anti-Programmed Death 1 Immunotherapy Response in Mouse Syngeneic Tumor Models von Georgiev, Peter, Muise, Eric S, Linn, Douglas E, Hinton, Marlene C, Wang, Yun, Cai, Mingmei, Cadzow, Louise, Wilson, Douglas C, Sukumar, Selvakumar, Caniga, Michael, Chen, Lan, Xiao, Hui, Yearley, Jennifer H, Sriram, Venkataraman, Nebozhyn, Michael, Sathe, Manjiri, Blumenschein, Wendy M, Kerr, Kimberly S, Hirsch, Heather A, Javaid, Sarah, Olow, Aleksandra K, Moy, Lily Y, Chiang, Derek Y, Loboda, Andrey, Cristescu, Razvan, Sadekova, Svetlana, Long, Brian J, McClanahan, Terrill K, Pinheiro, Elaine M

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Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells von Sukumar, Selvakumar, Wilson, Douglas C, Yu, Ying, Wong, Jerelyn, Naravula, Saraswathi, Ermakov, Grigori, Riener, Romina, Bhagwat, Bhagyashree, Necheva, Antoaneta S, Grein, Jeff, Churakova, Tatyana, Mangadu, Ruban, Georgiev, Peter, Manfra, Denise, Pinheiro, Elaine M, Sriram, Venkataraman, Bailey, Wendy J, Herzyk, Danuta, McClanahan, Terrill K, Willingham, Aarron, Beebe, Amy M, Sadekova, Svetlana

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Ena/VASP Is Required for Neuritogenesis in the Developing Cortex von Kwiatkowski, Adam V., Rubinson, Douglas A., Dent, Erik W., Edward van Veen, J., Leslie, Jonathan D., Zhang, Jiangyang, Mebane, Leslie M., Philippar, Ulrike, Pinheiro, Elaine M., Burds, Aurora A., Bronson, Roderick T., Mori, Susumu, Fässler, Reinhard, Gertler, Frank B.

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Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons von Pinheiro, Elaine M, Norovich, Amy L, Gertler, Frank B, Xie, Zhigang, Vidaki, Marina, Tsai, Li-Huei

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Multiple EGFR ligands participate in guiding migrating border cells von McDonald, Jocelyn A., Pinheiro, Elaine M., Kadlec, Lisa, Schupbach, Trudi, Montell, Denise J.

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BET Bromodomain Inhibition Suppresses Human T Cell Function von Georgiev, Peter, Wang, Yun, Muise, Eric S, Bandi, Madhavi L, Blumenschein, Wendy, Sathe, Manjiri, Pinheiro, Elaine M, Shumway, Stuart D

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Abstract 1328: Molecular characterization of mouse syngeneic tumor models in response to treatment with anti-PD-1 immunotherapy von Hirsch, Heather A., Pinheiro, Elaine M., Cai, Mingmei, Ma, Yanhong, Sathe, Manjiri, Ayers, Mark, McClanahan, Terrill K.

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Abstract 543: Preclinical combination strategies to enhance the efficacy of the anti-PD-1 antibody pembrolizumab von Pinheiro, Elaine M., Hinton, Marlene, Mangadu, Ruban, Cai, Mingmei, Phan, Uyen, Nebozhyn, Michael, Hirsch, Heather, Loboda, Andrey, Javaid, Sarah, Wang, Yaolin, Sriram, Venkataraman, Phillips, Joseph H., McClanahan, Terri, Long, Brian

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Differential immune microenvironments and response to immune checkpoint blockade amongst molecular subtypes of murine medulloblastoma von Pham, Christina D., Flores, Catherine, Yang, Changlin, Pinheiro, Elaine M., Yearley, Jennifer H., Sayour, Elias J., Pei, Yanxin, Moore, Colin, McLendon, Roger E., Huang, Jianping, Sampson, John H., Wechsler-Reya, Robert, Mitchell, Duane A.

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