Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex von Bussiere, Dirksen E., Xie, Lili, Srinivas, Honnappa, Shu, Wei, Burke, Ashley, Be, Celine, Zhao, Junping, Godbole, Adarsh, King, Dan, Karki, Rajeshri G., Hornak, Viktor, Xu, Fangmin, Cobb, Jennifer, Carte, Nathalie, Frank, Andreas O., Frommlet, Alexandra, Graff, Patrick, Knapp, Mark, Fazal, Aleem, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Beckwith, Rohan, Voshol, Hans, Wiesmann, Christian, Solomon, Jonathan M., Paulk, Joshiawa

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The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer von Friboulet, Luc, Li, Nanxin, Katayama, Ryohei, Lee, Christian C, Gainor, Justin F, Crystal, Adam S, Michellys, Pierre-Yves, Awad, Mark M, Yanagitani, Noriko, Kim, Sungjoon, Pferdekamper, AnneMarie C, Li, Jie, Kasibhatla, Shailaja, Sun, Frank, Sun, Xiuying, Hua, Su, McNamara, Peter, Mahmood, Sidra, Lockerman, Elizabeth L, Fujita, Naoya, Nishio, Makoto, Harris, Jennifer L, Shaw, Alice T, Engelman, Jeffrey A

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EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor von Jia, Yong, Juarez, Jose, Li, Jie, Manuia, Mari, Niederst, Matthew J, Tompkins, Celin, Timple, Noelito, Vaillancourt, Mei-Ting, Pferdekamper, AnneMarie Culazzo, Lockerman, Elizabeth L, Li, Chun, Anderson, Jennifer, Costa, Carlotta, Liao, Debbie, Murphy, Eric, DiDonato, Michael, Bursulaya, Badry, Lelais, Gerald, Barretina, Jordi, McNeill, Matthew, Epple, Robert, Marsilje, Thomas H, Pathan, Nuzhat, Engelman, Jeffrey A, Michellys, Pierre-Yves, McNamara, Peter, Harris, Jennifer, Bender, Steven, Kasibhatla, Shailaja

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Target-Based Identification and Optimization of 5‑Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay von Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sébastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phil B, Michellys, Pierre-Yves, Deane, Jonathan, Junt, Tobias, Zipfel, Géraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland, Betschart, Claudia

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Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain von Lee, Christian C, Jia, Yong, Li, Nanxin, Sun, Xiuying, Ng, Kenneth, Ambing, Eileen, Gao, Mu-Yun, Hua, Su, Chen, Connie, Kim, Sungjoon, Michellys, Pierre-Yves, Lesley, Scott A, Harris, Jennifer L, Spraggon, Glen

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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors von Jia, Yong, Yun, Cai-Hong, Park, Eunyoung, Ercan, Dalia, Manuia, Mari, Juarez, Jose, Xu, Chunxiao, Rhee, Kevin, Chen, Ting, Zhang, Haikuo, Palakurthi, Sangeetha, Jang, Jaebong, Lelais, Gerald, DiDonato, Michael, Bursulaya, Badry, Michellys, Pierre-Yves, Epple, Robert, Marsilje, Thomas H., McNeill, Matthew, Lu, Wenshuo, Harris, Jennifer, Bender, Steven, Wong, Kwok-Kin, Jänne, Pasi A., Eck, Michael J.

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Author Correction: Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex von Bussiere, Dirksen E., Xie, Lili, Srinivas, Honnappa, Shu, Wei, Burke, Ashley, Be, Celine, Zhao, Junping, Godbole, Adarsh, King, Dan, Karki, Rajeshri G., Hornak, Viktor, Xu, Fangmin, Cobb, Jennifer, Carte, Nathalie, Frank, Andreas O., Frommlet, Alexandra, Graff, Patrick, Knapp, Mark, Fazal, Aleem, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Beckwith, Rohan, Voshol, Hans, Wiesmann, Christian, Solomon, Jonathan M., Paulk, Joshiawa

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Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro- N 2-(2-isopropoxy-5-methyl-... von Marsilje, Thomas H., Pei, Wei, Chen, Bei, Lu, Wenshuo, Uno, Tetsuo, Jin, Yunho, Jiang, Tao, Kim, Sungjoon, Li, Nanxin, Warmuth, Markus, Sarkisova, Yelena, Sun, Frank, Steffy, Auzon, Pferdekamper, AnneMarie C., Li, Allen G., Joseph, Sean B., Kim, Young, Liu, Bo, Tuntland, Tove, Cui, Xiaoming, Gray, Nathanael S., Steensma, Ruo, Wan, Yongqin, Jiang, Jiqing, Chopiuk, Greg, Li, Jie, Gordon, W. Perry, Richmond, Wendy, Johnson, Kevin, Chang, Jonathan, Groessl, Todd, He, You-Qun, Phimister, Andrew, Aycinena, Alex, Lee, Christian C., Bursulaya, Badry, Karanewsky, Donald S., Seidel, H. Martin, Harris, Jennifer L., Michellys, Pierre-Yves

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NMR Structural Studies of Interactions of a Small, Nonpeptidyl Tpo Mimic with the Thrombopoietin Receptor Extracellular Juxtamembrane and Transmembrane Domains von Kim, Min-Ju, Park, Sang Ho, Opella, Stanley J., Marsilje, Thomas H., Michellys, Pierre-Yves, Seidel, H. Martin, Tian, Shin-Shay

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Discovery of (R,E)‑N‑(7-Chloro-1-(1-[4-(dimethylamino)­but-2-enoyl]azepan-3-yl)‑1H‑benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent... von Lelais, Gérald, Epple, Robert, Marsilje, Thomas H, Long, Yun O, McNeill, Matthew, Chen, Bei, Lu, Wenshuo, Anumolu, Jaganmohan, Badiger, Sangamesh, Bursulaya, Badry, DiDonato, Michael, Fong, Rina, Juarez, Jose, Li, Jie, Manuia, Mari, Mason, Daniel E, Gordon, Perry, Groessl, Todd, Johnson, Kevin, Jia, Yong, Kasibhatla, Shailaja, Li, Chun, Isbell, John, Spraggon, Glen, Bender, Steven, Michellys, Pierre-Yves

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Discovery of small molecules that target a tertiary-structured RNA von Menichelli, Elena, Lam, Bianca J, Wang, Yu, Wang, Vivian S, Shaffer, Jennifer, Tjhung, Katrina F, Bursulaya, Badry, Nguyen, Truc Ngoc, Vo, Todd, Alper, Phillip B, McAllister, Christopher S, Jones, David H, Spraggon, Glen, Michellys, Pierre-Yves, Joslin, John, Joyce, Gerald F, Rogers, Jeff

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Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology von Kingsley, Laura J, He, Xiaohui, McNeill, Matthew, Nelson, John, Nikulin, Victor, Ma, Zhiwei, Lu, Wenshuo, Zhou, Vicki W, Manuia, Mari, Kreusch, Andreas, Gao, Mu-Yun, Witmer, Darbi, Vaillancourt, Mei-Ting, Lu, Min, Greenblatt, Sarah, Lee, Christian, Vashisht, Ajay, Bender, Steven, Spraggon, Glen, Michellys, Pierre-Yves, Jia, Yong, Haling, Jacob R, Lelais, Gérald

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Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway von Alper, Phil B., Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Géraldine, Gordon, Perry, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, McKeever, Una, Michellys, Pierre-Yves, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James S., Syka, Peter, Zhang, Yi, Zhu, Xuefeng

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Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes von Leibowitz, Mark D, Ardecky, Robert J, Boehm, Marcus F, Broderick, Carol L, Carfagna, Mark A, Crombie, Diane L, D’Arrigo, Jennifer, Etgen, Garrett J, Faul, Margaret M, Grese, Timothy A, Havel, Henry, Hein, Nancy I, Heyman, Richard A, Jolley, Diane, Klausing, Kay, Liu, Sha, Mais, Dale E, Mapes, Christopher M, Marschke, Keith B, Michellys, Pierre-Yves, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathleen M, Pascual, Bernadette, Rungta, Deepa, Tyhonas, John S, Urcan, Mary S, Wardlow, Marilyn, Yumibe, Nathan, Reifel-Miller, Anne

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Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases von Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi, Zink, Florence, Zipfel, Géraldine, Hawtin, Stuart, Junt, Tobias, Michellys, Pierre-Yves

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Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases von He, Xiaohui, Da Ros, Sara, Nelson, John, Zhu, Xuefeng, Jiang, Tao, Okram, Barun, Jiang, Songchun, Michellys, Pierre-Yves, Iskandar, Maya, Espinola, Sheryll, Jia, Yong, Bursulaya, Badry, Kreusch, Andreas, Gao, Mu-Yun, Spraggon, Glen, Baaten, Janine, Clemmer, Leah, Meeusen, Shelly, Huang, David, Hill, Robert, Nguyen-Tran, Vân, Fathman, John, Liu, Bo, Tuntland, Tove, Gordon, Perry, Hollenbeck, Thomas, Ng, Kenneth, Shi, Jian, Bordone, Laura, Liu, Hong

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Discovery of Orally Active Hydroxyethylamine Based SPPL2a Inhibitors von Velcicky, Juraj, Mathison, Casey J. N, Nikulin, Victor, Pflieger, Daniel, Epple, Robert, Azimioara, Mihai, Cow, Christopher, Michellys, Pierre-Yves, Rigollier, Pascal, Beisner, Daniel R, Bodendorf, Ursula, Guerini, Danilo, Liu, Bo, Wen, Ben, Zaharevitz, Samantha, Brandl, Trixi

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Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors von Michellys, Pierre-Yves, Chen, Bei, Jiang, Tao, Jin, Yunho, Lu, Wenshuo, Marsilje, Thomas H., Pei, Wei, Uno, Tetsuo, Zhu, Xuefeng, Wu, Baogen, Nguyen, Truc Ngoc, Bursulaya, Badry, Lee, Christian, Li, Nanxin, Kim, Sungjoon, Tuntland, Tove, Liu, Bo, Sun, Frank, Steffy, Auzon, Hood, Tami

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Syk inhibitors with high potency in presence of blood von Thoma, Gebhard, Blanz, Joachim, Bühlmayer, Peter, Drückes, Peter, Kittelmann, Matthias, Smith, Alexander B., van Eis, Maurice, Vangrevelinghe, Eric, Zerwes, Hans-Günter, Che, Jianwei (John), He, Xiaohui, Jin, Yunho, Lee, Christian C., Michellys, Pierre-Yves, Uno, Tetsuo, Liu, Hong

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Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors von Fairhurst, Robin A., Marsilje, Thomas H., Stutz, Stefan, Boos, Andreas, Niklaus, Michel, Chen, Bei, Jiang, Songchun, Lu, Wenshuo, Furet, Pascal, McCarthy, Clive, Stauffer, Frédéric, Guagnano, Vito, Vaupel, Andrea, Michellys, Pierre-Yves, Schnell, Christian, Jeay, Sébastien

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