Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification—an approach to classification of patients with t-MDS von Kuendgen, A., Nomdedeu, M., Tuechler, H., Garcia-Manero, G., Komrokji, R. S., Sekeres, M. A., Della Porta, M. G., Cazzola, M., DeZern, A. E., Roboz, G. J., Steensma, D. P., Van de Loosdrecht, A. A., Schlenk, R. F., Grau, J., Calvo, X., Blum, S., Pereira, A., Valent, P., Costa, D., Giagounidis, A., Xicoy, B., Döhner, H., Platzbecker, U., Pedro, C., Lübbert, M., Oiartzabal, I., Díez-Campelo, M., Cedena, M. T., Machherndl-Spandl, S., López-Pavía, M., Baldus, C. D., Martinez-de-Sola, M., Stauder, R., Merchan, B., List, A., Ganster, C., Schroeder, T., Voso, M. T., Pfeilstöcker, M., Sill, H., Hildebrandt, B., Esteve, J., Nomdedeu, B., Cobo, F., Haas, R., Sole, F., Germing, U., Greenberg, P. L., Haase, D., Sanz, G.

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Comorbidity as prognostic variable in MDS: comparative evaluation of the HCT-CI and CCI in a core dataset of 419 patients of the Austrian MDS Study Group von Sperr, W. R., Wimazal, F., Kundi, M., Baumgartner, C., Nösslinger, T., Makrai, A., Stauder, R., Krieger, O., Pfeilstöcker, M., Valent, P.

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The new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification von Nachtkamp, K., Strupp, C., Vukelja, M., Kasprzak, A., Haase, D., Ganster, C., Hildebrandt, B., Betz, B., Giagounidis, A., Aul, C., Blum, S., Hofmann, W. K., Pfeilstöcker, M., Valent, P., Lübbert, M., Seidl, M., Rudelius, M., Stauder, R., Krieger, O., Götze, K. S., Bobak, J., Kündgen, A., Schulz, F., Dietrich, S., Kobbe, G., Gattermann, N., Germing, U.

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Prognostic factors and follow-up parameters in patients with paroxysmal nocturnal hemoglobinuria (PNH): experience of the Austrian PNH network von Füreder, Wolfgang, Sperr, W. R., Heibl, S., Zebisch, A., Pfeilstöcker, M., Stefanzl, G., Jäger, E., Greiner, G., Schwarzinger, I., Kundi, M., Keil, F., Hoermann, G., Bettelheim, P., Valent, P.

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Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q von Mallo, M, Cervera, J, Schanz, J, Such, E, García-Manero, G, Luño, E, Steidl, C, Espinet, B, Vallespí, T, Germing, U, Blum, S, Ohyashiki, K, Grau, J, Pfeilstöcker, M, Hernández, J M, Noesslinger, T, Giagounidis, A, Aul, C, Calasanz, M J, Martín, M L, Valent, P, Collado, R, Haferlach, C, Fonatsch, C, Lübbert, M, Stauder, R, Hildebrandt, B, Krieger, O, Pedro, C, Arenillas, L, Sanz, M Á, Valencia, A, Florensa, L, Sanz, G F, Haase, D, Solé, F

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Prognostic impact of age and gender in 897 untreated patients with primary myelodysplastic syndromes von Nösslinger, T., Tüchler, H., Germing, U., Sperr, W. R., Krieger, O., Haase, D., Lübbert, M., Stauder, R., Giagounidis, A., Valent, P., Pfeilstöcker, M.

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The IPSS-R has prognostic impact in untreated patients with MDS del(5q) von Kaivers, J., Lauseker, M., Hildebrandt, B., Fenaux, P., Pfeilstöcker, M., Valent, P., Platzbecker, U., Latagliata, R., Oliva, E.N., Xicoy, B., Götze, K., Ganster, C., Haase, D., Bug, G., Kündgen, A., Gattermann, N., Haas, R., Germing, U.

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Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-... von Della Porta, M G, Tuechler, H, Malcovati, L, Schanz, J, Sanz, G, Garcia-Manero, G, Solé, F, Bennett, J M, Bowen, D, Fenaux, P, Dreyfus, F, Kantarjian, H, Kuendgen, A, Levis, A, Cermak, J, Fonatsch, C, Le Beau, M M, Slovak, M L, Krieger, O, Luebbert, M, Maciejewski, J, Magalhaes, S M M, Miyazaki, Y, Pfeilstöcker, M, Sekeres, M A, Sperr, W R, Stauder, R, Tauro, S, Valent, P, Vallespi, T, van de Loosdrecht, A A, Germing, U, Haase, D, Greenberg, P L, Cazzola, M

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240 DYSPLASIAS REVISITED – CONSIDERATIONS FOR A MULTIDIMENSIONAL APPROACH TO HETEROGENEITY OF MDS: DATA ON 1979 PATIENTS FROM THE GERMAN AUSTRIAN DATA BASE von Pfeilstöcker, M, Tuechler, H, Nachtkamp, K, Platzbecker, U, Schönmetzler, A, Sperr, W, Stauder, R, Strupp, C, Valent, P, Germing, U

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Iron overload in myelodysplastic syndromes (MDS) - diagnosis, management, and response criteria: a proposal of the Austrian MDS platform von Valent, P., Krieger, O., Stauder, R., Wimazal, F., Nösslinger, T., Sperr, W. R., Sill, H., Bettelheim, P., Pfeilstöcker, M.

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Vitamin D supports the efficiency of decitabine for induction of differentiation, apoptosis and osteocalcin expression in leukemia and mastocytosis von Karlic, H, Reitermaier, R, Thaler, R, Varga, J, Spitzer, S, Pfeilstöcker, M, Valent, P, Klaushofer, K, Varga, F

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318 THE IPSS-R HAS PROGNOSTIC IMPACT IN UNTREATED PATIENTS WITH MDS DEL(5Q) von Schemenau, J, Lauseker, M, Hildebrandt, B, Fenaux, P, Pfeilstöcker, M, Valent, P, Platzbecker, U, Kündgen, A, Bug, G, Haas, R, Germing, U

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Deferasirox induces regression of iron overload in patients with myelodysplastic syndromes von Wimazal, F., Nösslinger, T., Baumgartner, C., Sperr, W. R., Pfeilstöcker, M., Valent, P.

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246 Epigenetic promoter-methylation regulates mRNA expression of apoptosis-mediators in MDS von Karlic, H, Varga, F, Herrmann, H, Valent, P, Pfeilstöcker, M

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P-111 Time changes in predictive power of MDS prognostic scores – Effects on revised scores such as the IPSS-R, impact of age von Pfeilstöcker, M, Tüchler, H, Nösslinger, T, Neukirchen, J, Sperr, W.R, Lübbert, M, Haase, D, Stauder, R, Krieger, O, Valent, P, Germing, U

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314 Prognostic impact of cytopenias in MDS – progress beyond the currently used cut-point concept von Pfeilstöcker, M, Tüchler, H, Schönmetzler, A, Nösslinger, T, Reisner, R, Schlögl, E, Pittermann, E

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Refinement of the international prognostic scoring system (IPSS) by including LDH as an additional prognostic variable to improve risk assessment in patients with primary myelodysp... von GERMING, U, HILDEBRANDT, B, STAUDE, R, GIAGOUNIDIS, A. A. N, STRUPP, C, KÜNDGEN, A, MUELLER, T, HAAS, R, GATTERMANN, N, AUL, C, PFEILSTÖCKER, M, NÖSSLINGER, T, VALENT, P, FONATSCH, C, LÜBBERT, M, HAASE, D, STEIDL, C, KRIEGER, O

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O-023 Did the prognosis of MDS patients improve during the last 30 years? von Neukirchen, J, Nachtkamp, K, Pfeilstöcker, M, Valent, P, Stauder, R, Blum, S, Lübbert, M, Haase, D, Götze, K, Hofmann, W.K, Schlenk, R, Giagounidis, A, Aul, C, Schulte, K, Lipke, J, Nusch, A, Krieger, O, Hegener, P, Weik, C, Letsch, A, Platzbecker, U, Kreutzer, K.A, Kobbe, G, Germing, U

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Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study von Germing, U, Lauseker, M, Hildebrandt, B, Symeonidis, A, Cermak, J, Fenaux, P, Kelaidi, C, Pfeilstöcker, M, Nösslinger, T, Sekeres, M, Maciejewski, J, Haase, D, Schanz, J, Seymour, J, Kenealy, M, Weide, R, Lübbert, M, Platzbecker, U, Valent, P, Götze, K, Stauder, R, Blum, S, Kreuzer, K-A, Schlenk, R, Ganser, A, Hofmann, W-K, Aul, C, Krieger, O, Kündgen, A, Haas, R, Hasford, J, Giagounidis, A

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318 A novel score optimized for accurate prediction of survival in patients with de novo myelodysplastic syndromes von Sperr, W.R, Kundi, M, Wimazal, F, Nösslinger, T, Schönmetzler-Makrei, A, Stauder, R, Krieger, O, Pfeilstöcker, M, Valent, P

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