Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells von Gannon, Hugh S., Zou, Tao, Kiessling, Michael K., Gao, Galen F., Cai, Diana, Choi, Peter S., Ivan, Alexandru P., Buchumenski, Ilana, Berger, Ashton C., Goldstein, Jonathan T., Cherniack, Andrew D., Vazquez, Francisca, Tsherniak, Aviad, Levanon, Erez Y., Hahn, William C., Meyerson, Matthew

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BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors von Wang, Xiaofeng, Wang, Su, Troisi, Emma C., Howard, Thomas P., Haswell, Jeffrey R., Wolf, Bennett K., Hawk, William H., Ramos, Pilar, Oberlick, Elaine M., Tzvetkov, Evgeni P., Ross, Aaron, Vazquez, Francisca, Hahn, William C., Park, Peter J., Roberts, Charles W. M.

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A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies von Boettcher, Steffen, Miller, Peter G., Sharma, Rohan, McConkey, Marie, Leventhal, Matthew, Krivtsov, Andrei V., Giacomelli, Andrew O., Wong, Waihay, Kim, Jesi, Chao, Sherry, Kurppa, Kari J., Yang, Xiaoping, Milenkowic, Kirsten, Piccioni, Federica, Root, David E., Rücker, Frank G., Flamand, Yael, Neuberg, Donna, Lindsley, R. Coleman, Jänne, Pasi A., Hahn, William C., Jacks, Tyler, Döhner, Hartmut, Armstrong, Scott A., Ebert, Benjamin L.

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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer von Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

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Somatic Superenhancer Duplications and Hotspot Mutations Lead to Oncogenic Activation of the KLF5 Transcription Factor von Zhang, Xiaoyang, Choi, Peter S, Francis, Joshua M, Gao, Galen F, Campbell, Joshua D, Ramachandran, Aruna, Mitsuishi, Yoichiro, Ha, Gavin, Shih, Juliann, Vazquez, Francisca, Tsherniak, Aviad, Taylor, Alison M, Zhou, Jin, Wu, Zhong, Berger, Ashton C, Giannakis, Marios, Hahn, William C, Cherniack, Andrew D, Meyerson, Matthew

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc von Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

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Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer von Lohr, Jens G, Adalsteinsson, Viktor A, Cibulskis, Kristian, Choudhury, Atish D, Rosenberg, Mara, Cruz-Gordillo, Peter, Francis, Joshua M, Zhang, Cheng-Zhong, Shalek, Alex K, Satija, Rahul, Trombetta, John J, Lu, Diana, Tallapragada, Naren, Tahirova, Narmin, Kim, Sora, Blumenstiel, Brendan, Sougnez, Carrie, Lowe, Alarice, Wong, Bang, Auclair, Daniel, Van Allen, Eliezer M, Nakabayashi, Mari, Lis, Rosina T, Lee, Gwo-Shu M, Li, Tiantian, Chabot, Matthew S, Ly, Amy, Taplin, Mary-Ellen, Clancy, Thomas E, Loda, Massimo, Regev, Aviv, Meyerson, Matthew, Hahn, William C, Kantoff, Philip W, Golub, Todd R, Getz, Gad, Boehm, Jesse S, Love, J Christopher

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Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas von Brastianos, Priscilla K, Taylor-Weiner, Amaro, Manley, Peter E, Jones, Robert T, Dias-Santagata, Dora, Thorner, Aaron R, Lawrence, Michael S, Rodriguez, Fausto J, Bernardo, Lindsay A, Schubert, Laura, Sunkavalli, Ashwini, Shillingford, Nick, Calicchio, Monica L, Lidov, Hart G W, Taha, Hala, Martinez-Lage, Maria, Santi, Mariarita, Storm, Phillip B, Lee, John Y K, Palmer, James N, Adappa, Nithin D, Scott, R Michael, Dunn, Ian F, Laws, Edward R, Stewart, Chip, Ligon, Keith L, Hoang, Mai P, Van Hummelen, Paul, Hahn, William C, Louis, David N, Resnick, Adam C, Kieran, Mark W, Getz, Gad, Santagata, Sandro

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An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer von Li, Ji, Choi, Peter S, Chaffer, Christine L, Labella, Katherine, Hwang, Justin H, Giacomelli, Andrew O, Kim, Jong Wook, Ilic, Nina, Doench, John G, Ly, Seav Huong, Dai, Chao, Hagel, Kimberly, Hong, Andrew L, Gjoerup, Ole, Goel, Shom, Ge, Jennifer Y, Root, David E, Zhao, Jean J, Brooks, Angela N, Weinberg, Robert A, Hahn, William C

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Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells von Scholl, Claudia, Fröhling, Stefan, Dunn, Ian F., Schinzel, Anna C., Barbie, David A., Kim, So Young, Silver, Serena J., Tamayo, Pablo, Wadlow, Raymond C., Ramaswamy, Sridhar, Döhner, Konstanze, Bullinger, Lars, Sandy, Peter, Boehm, Jesse S., Root, David E., Jacks, Tyler, Hahn, William C., Gilliland, D. Gary

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Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity von Williams, Hannah L, Dias Costa, Andressa, Zhang, Jinming, Raghavan, Srivatsan, Winter, Peter S, Kapner, Kevin S, Ginebaugh, Scott P, Väyrynen, Sara A, Väyrynen, Juha P, Yuan, Chen, Navia, Andrew W, Wang, Junning, Yang, Annan, Bosse, Timothy L, Kalekar, Radha L, Lowder, Kristen E, Lau, Mai Chan, Elganainy, Dalia, Morales-Oyarvide, Vicente, Rubinson, Douglas A, Singh, Harshabad, Perez, Kimberly, Cleary, James M, Clancy, Thomas E, Wang, Jiping, Mancias, Joseph D, Brais, Lauren K, Hill, Emma R, Kozak, Margaret M, Linehan, David C, Dunne, Richard F, Chang, Daniel T, Koong, Albert C, Hezel, Aram F, Hahn, William C, Shalek, Alex K, Aguirre, Andrew J, Nowak, Jonathan A, Wolpin, Brian M

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Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism von Schauer, Nathan J., Liu, Xiaoxi, Magin, Robert S., Doherty, Laura M., Chan, Wai Cheung, Ficarro, Scott B., Hu, Wanyi, Roberts, Rebekka M., Iacob, Roxana E., Stolte, Björn, Giacomelli, Andrew O., Perera, Sumner, McKay, Kyle, Boswell, Sarah A., Weisberg, Ellen L., Ray, Arghya, Chauhan, Dharminder, Dhe-Paganon, Sirano, Anderson, Ken C., Griffin, James D., Li, Jianing, Hahn, William C., Sorger, Peter K., Engen, John R., Stegmaier, Kimberly, Marto, Jarrod A., Buhrlage, Sara J.

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MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors von Howard, Thomas P, Arnoff, Taylor E, Song, Melinda R, Giacomelli, Andrew O, Wang, Xiaofeng, Hong, Andrew L, Dharia, Neekesh V, Wang, Su, Vazquez, Francisca, Pham, Minh-Tam, Morgan, Ann M, Wachter, Franziska, Bird, Gregory H, Kugener, Guillaume, Oberlick, Elaine M, Rees, Matthew G, Tiv, Hong L, Hwang, Justin H, Walsh, Katherine H, Cook, April, Krill-Burger, John M, Tsherniak, Aviad, Gokhale, Prafulla C, Park, Peter J, Stegmaier, Kimberly, Walensky, Loren D, Hahn, William C, Roberts, Charles W M

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Systematic RNA interference reveals that oncogenic KRAS -driven cancers require TBK1 von Kim, So Young, Sabatini, David M, Michel, Kathrin, Tamayo, Pablo, Weir, Barbara A, Le, Hanh, Mermel, Craig, Gupta, Piyush B, Meyerson, Matthew, Hahn, William C, Schinzel, Anna C, Hoersch, Sebastian, Lander, Eric S, Sandy, Peter, Mesirov, Jill P, Sheng, Qing, Boehm, Jesse S, Meylan, Etienne, Gilliland, D. Gary, Barbie, David A, Sos, Martin L, Fröhling, Stefan, Chan, Edmond M, Wittner, Ben S, Ramaswamy, Sridhar, Livingston, David M, Root, David E, Reiling, Jan H, Wadlow, Raymond C, Dunn, Ian F, Thomas, Roman K, Scholl, Claudia, Moody, Susan E, Silver, Serena J, Jacks, Tyler

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Minimizing the risk of reporting false positives in large-scale RNAi screens von Echeverri, Christophe J, Beachy, Philip A, Baum, Buzz, Boutros, Michael, Buchholz, Frank, Chanda, Sumit K, Downward, Julian, Ellenberg, Jan, Fraser, Andrew G, Hacohen, Nir, Hahn, William C, Jackson, Aimee L, Kiger, Amy, Linsley, Peter S, Lum, Lawrence, Ma, Yong, Mathey-Prévôt, Bernard, Root, David E, Sabatini, David M, Taipale, Jussi, Perrimon, Norbert, Bernards, René

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Scalable, compressed phenotypic screening using pooled perturbations von Liu, Nuo, Kattan, Walaa E, Mead, Benjamin E, Kummerlowe, Conner, Cheng, Thomas, Ingabire, Sarah, Cheah, Jaime H, Soule, Christian K, Vrcic, Anita, McIninch, Jane K, Triana, Sergio, Guzman, Manuel, Dao, Tyler T, Peters, Joshua M, Lowder, Kristen E, Crawford, Lorin, Amini, Ava P, Blainey, Paul C, Hahn, William C, Cleary, Brian, Bryson, Bryan, Winter, Peter S, Raghavan, Srivatsan, Shalek, Alex K

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Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer von Viswanathan, Srinivas R., Nogueira, Marina F., Buss, Colin G., Krill-Burger, John M., Wawer, Mathias J., Malolepsza, Edyta, Berger, Ashton C., Choi, Peter S., Shih, Juliann, Taylor, Alison M., Tanenbaum, Benjamin, Pedamallu, Chandra Sekhar, Cherniack, Andrew D., Tamayo, Pablo, Strathdee, Craig A., Lage, Kasper, Carr, Steven A., Schenone, Monica, Bhatia, Sangeeta N., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Meyerson, Matthew

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A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer von Tang, Stephen, Sethunath, Vidyalakshmi, Metaferia, Nebiyou Y., Nogueira, Marina F., Gallant, Daniel S., Garner, Emma R., Lairson, Lauren A., Penney, Christopher M., Li, Jiao, Gelbard, Maya K., Alaiwi, Sarah Abou, Seo, Ji-Heui, Hwang, Justin H., Strathdee, Craig A., Baca, Sylvan C., AbuHammad, Shatha, Zhang, Xiaoyang, Doench, John G., Hahn, William C., Takeda, David Y., Freedman, Matthew L., Choi, Peter S., Viswanathan, Srinivas R.

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Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells von Gannon, Hugh S., Zou, Tao, Kiessling, Michael K., Gao, Galen F., Cai, Diana, Choi, Peter S., Ivan, Alexandru P., Buchumenski, Ilana, Berger, Ashton C., Goldstein, Jonathan T., Cherniack, Andrew D., Vazquez, Francisca, Tsherniak, Aviad, Levanon, Erez Y., Hahn, William C., Meyerson, Matthew

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The Telomerase Reverse Transcriptase Regulates Chromatin State and DNA Damage Responses von Masutomi, Kenkichi, Possemato, Richard, Judy M. Y. Wong, Currier, Jennifer L., Tothova, Zuzana, Manola, Judith B., Ganesan, Shridar, Lansdorp, Peter M., Collins, Kathleen, Hahn, William C., Livingston, David M.

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