TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1 von Dibble, Christian C., Elis, Winfried, Menon, Suchithra, Qin, Wei, Klekota, Justin, Asara, John M., Finan, Peter M., Kwiatkowski, David J., Murphy, Leon O., Manning, Brendan D.

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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 von Düvel, Katrin, Yecies, Jessica L., Menon, Suchithra, Raman, Pichai, Lipovsky, Alex I., Souza, Amanda L., Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, Vander Heiden, Matthew G., MacKeigan, Jeffrey P., Finan, Peter M., Clish, Clary B., Murphy, Leon O., Manning, Brendan D.

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy von Nicklin, Paul, Bergman, Philip, Zhang, Bailin, Triantafellow, Ellen, Wang, Henry, Nyfeler, Beat, Yang, Haidi, Hild, Marc, Kung, Charles, Wilson, Christopher, Myer, Vic E., MacKeigan, Jeffrey P., Porter, Jeffrey A., Wang, Y. Karen, Cantley, Lewis C., Finan, Peter M., Murphy, Leon O.

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner von Hao, Huai-Xiang, Xie, Yang, Zhang, Yue, Charlat, Olga, Oster, Emma, Avello, Monika, Lei, Hong, Mickanin, Craig, Liu, Dong, Ruffner, Heinz, Mao, Xiaohong, Ma, Qicheng, Zamponi, Raffaella, Bouwmeester, Tewis, Finan, Peter M., Kirschner, Marc W., Porter, Jeffery A., Serluca, Fabrizio C., Cong, Feng

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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling von Zhang, Yue, Liu, Shanming, Mickanin, Craig, Feng, Yan, Charlat, Olga, Michaud, Gregory A., Schirle, Markus, Shi, Xiaoying, Hild, Marc, Bauer, Andreas, Myer, Vic E., Finan, Peter M., Porter, Jeffery A., Huang, Shih-Min A., Cong, Feng

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling von Bauer, Andreas, Myer, Vic, Fawell, Stephen, Ghidelli, Sonja, Shi, Xiaoying, Rau, Christina, Schirle, Markus, Serluca, Fabrizio, Zhang, Yue, Bouwmeester, Tewis, Charlat, Olga, Mickanin, Craig, Curtis, Daniel, Stegmeier, Frank, Hild, Marc, Cong, Feng, Mishina, Yuji M, Wilson, Christopher J, Liu, Shanming, Wiessner, Stephanie, Tomlinson, Ronald, Fazal, Aleem, Shao, Wenlin, Shultz, Michael, Wiellette, Elizabeth, Michaud, Gregory A, Cheng, Hong, Schlegl, Judith, Finan, Peter M, Porter, Jeffery A, Lu, Chris, Cheung, Atwood, Lengauer, Christoph, Tallarico, John A, Kirschner, Marc W, Huang, Shih-Min A

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor a... von Maira, Sauveur-Michel, Stauffer, Frédéric, Brueggen, Josef, Furet, Pascal, Schnell, Christian, Fritsch, Christine, Brachmann, Saskia, Chène, Patrick, De Pover, Alain, Schoemaker, Kevin, Fabbro, Doriano, Gabriel, Daniela, Simonen, Marjo, Murphy, Leon, Finan, Peter, Sellers, William, García-Echeverría, Carlos

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Relieving Autophagy and 4EBP1 from Rapamycin Resistance von Nyfeler, Beat, Bergman, Philip, Triantafellow, Ellen, Wilson, Christopher J., Zhu, Yanyi, Radetich, Branko, Finan, Peter M., Klionsky, Daniel J., Murphy, Leon O.

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Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice von Fetalvero, Kristina M., Yu, Yenyen, Goetschkes, Margaret, Liang, Guiqing, Valdez, Reginald A., Gould, Ty, Triantafellow, Ellen, Bergling, Sebastian, Loureiro, Joseph, Eash, John, Lin, Victor, Porter, Jeffrey A., Finan, Peter M., Walsh, Kenneth, Yang, Yi, Mao, Xiaohong, Murphy, Leon O.

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo von Dowdle, William E., Nyfeler, Beat, Nagel, Jane, Elling, Robert A., Liu, Shanming, Triantafellow, Ellen, Menon, Suchithra, Wang, Zuncai, Honda, Ayako, Pardee, Gwynn, Cantwell, John, Luu, Catherine, Cornella-Taracido, Ivan, Harrington, Edmund, Fekkes, Peter, Lei, Hong, Fang, Qing, Digan, Mary Ellen, Burdick, Debra, Powers, Andrew F., Helliwell, Stephen B., D’Aquin, Simon, Bastien, Julie, Wang, Henry, Wiederschain, Dmitri, Kuerth, Jenny, Bergman, Philip, Schwalb, David, Thomas, Jason, Ugwonali, Savuth, Harbinski, Fred, Tallarico, John, Wilson, Christopher J., Myer, Vic E., Porter, Jeffery A., Bussiere, Dirksen E., Finan, Peter M., Labow, Mark A., Mao, Xiaohong, Hamann, Lawrence G., Manning, Brendan D., Valdez, Reginald A., Nicholson, Thomas, Schirle, Markus, Knapp, Mark S., Keaney, Erin P., Murphy, Leon O.

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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies von Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng, Nusse, Roeland

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RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth von Nyfeler, Beat, Chen, Yan, Li, Xiaoyan, Pinzon-Ortiz, Maria, Wang, Zuncai, Reddy, Anupama, Pradhan, Elina, Das, Rita, Lehár, Joseph, Schlegel, Robert, Finan, Peter M, Cao, Z Alexander, Murphy, Leon O, Huang, Alan

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R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5 von Ruffner, Heinz, Sprunger, Joëlle, Charlat, Olga, Leighton-Davies, Juliet, Grosshans, Bianka, Salathe, Adrian, Zietzling, Svenja, Beck, Valérie, Therier, Maxime, Isken, Andrea, Xie, Yang, Zhang, Yue, Hao, Huaixiang, Shi, Xiaoying, Liu, Dong, Song, Qinhui, Clay, Ieuan, Hintzen, Gabriele, Tchorz, Jan, Bouchez, Laure C, Michaud, Gregory, Finan, Peter, Myer, Vic E, Bouwmeester, Tewis, Porter, Jeff, Hild, Marc, Bassilana, Fred, Parker, Christian N, Cong, Feng

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Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth von Harbinski, Fred, Craig, Vanessa J, Sanghavi, Sneha, Jeffery, Douglas, Liu, Lijuan, Sheppard, Kelly Ann, Wagner, Sabrina, Stamm, Christelle, Buness, Andreas, Chatenay-Rivauday, Christian, Yao, Yao, He, Feng, Lu, Chris X, Guagnano, Vito, Metz, Thomas, Finan, Peter M, Hofmann, Francesco, Sellers, William R, Porter, Jeffrey A, Myer, Vic E, Graus-Porta, Diana, Wilson, Christopher J, Buckler, Alan, Tiedt, Ralph

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39 von Bassilana, Frederic, Carlson, Adam, DaSilva, Jennifer A, Grosshans, Bianka, Vidal, Solange, Beck, Valerie, Wilmeringwetter, Barbara, Llamas, Luis A, Showalter, Todd B, Rigollier, Pascal, Bourret, Aaron, Ramamurthy, Arun, Wu, Xu, Harbinski, Fred, Plonsky, Samantha, Lee, Lac, Ruffner, Heinz, Grandi, Paola, Schirle, Markus, Jenkins, Jeremy, Sailer, Andreas W, Bouwmeester, Tewis, Porter, Jeffrey A, Myer, Vic, Finan, Peter M, Tallarico, John A, Kelleher, Joseph F, Seuwen, Klaus, Jain, Rishi K, Luchansky, Sarah J

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Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo von Honda, Ayako, Harrington, Edmund, Cornella-Taracido, Ivan, Furet, Pascal, Knapp, Mark S, Glick, Meir, Triantafellow, Ellen, Dowdle, William E, Wiedershain, Dmitri, Maniara, Wieslawa, Moore, Christine, Finan, Peter M, Hamann, Lawrence G, Firestone, Brant, Murphy, Leon O, Keaney, Erin P

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation von Emery, Caroline M, Hieronymus, Haley, Zhao, Jean J, Boehm, Jesse S, Golub, Todd, Yang, Xiaoping, Root, David E, Roberts, Thomas M, Hahn, William C, Hill, David E, Wilson, Christopher J, Weber, Barbara L, Garraway, Levi A, Johnson, Laura A, Kim, Sungjoon, Harris, Jennifer L, Kim, So Young, Vidal, Marc, Finan, Peter M, Myer, Vic E, Sellers, William R, Barretina, Jordi, Alkan, Ozan, Thomas, Sapana R, Wardwell, Leslie, Cogdill, Alexandria P, Dummer, Reinhard, Schlegel, Robert, Stransky, Nicolas, Flaherty, Keith T, Wargo, Jennifer A, Murray, Ryan R, Johannessen, Cory M, Salehi-Ashtiani, Kourosh, Caponigro, Giordano

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Genetic ablation of PI3Kγ results in defective IL‐17RA signalling in T lymphocytes and increased IL‐17 levels von Harris, Stephanie J., Ciuclan, Loredana, Finan, Peter M., Wymann, Matthias P., Walker, Christoph, Westwick, John, Ward, Stephen G., Thomas, Matthew J.

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Down-Regulation of Class II Phosphoinositide 3-Kinase α Expression below a Critical Threshold Induces Apoptotic Cell Death von Elis, Winfried, Triantafellow, Ellen, Wolters, Natalie M, Sian, Katie R, Caponigro, Giordano, Borawski, Jason, Gaither, L Alex, Murphy, Leon O, Finan, Peter M, Mackeigan, Jeffrey P

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IL-10 expression profiling in human monocytes von Williams, Lynn, Jarai, Gabor, Smith, Alexandra, Finan, Peter

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