On-demand male contraception via acute inhibition of soluble adenylyl cyclase von Balbach, Melanie, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Ritagliati, Carla, Myers, Robert W., Huggins, David J., Steegborn, Clemens, Miranda, Ileana C., Meinke, Peter T., Buck, Jochen, Levin, Lonny R.

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Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization von Balbach, Melanie, Ghanem, Lubna, Rossetti, Thomas, Kaur, Navpreet, Ritagliati, Carla, Ferreira, Jacob, Krapf, Dario, Puga Molina, Lis C, Santi, Celia Maria, Hansen, Jan Niklas, Wachten, Dagmar, Fushimi, Makoto, Meinke, Peter T, Buck, Jochen, Levin, Lonny R

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PPARs: therapeutic targets for metabolic disease von Berger, Joel P., Akiyama, Taro E., Meinke, Peter T.

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Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential von Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

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Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential von Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

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Transforming Academic Drug Discovery von Meinke, Peter T.

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Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis von Singh, Sheo B, Xu, Libo, Meinke, Peter T, Kurepina, Natalia, Kreiswirth, Barry N, Olsen, David B, Young, Katherine

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Guggulsterone Is a Farnesoid X Receptor Antagonist in Coactivator Association Assays but Acts to Enhance Transcription of Bile Salt Export Pump von Cui, Jisong, Huang, Li, Zhao, Annie, Lew, Jane-L, Yu, Jinghua, Sahoo, Soumya, Meinke, Peter T, Royo, Inmaculada, Pelaez, Fernando, Wright, Samuel D

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Design, Synthesis, Structure–Function Relationship, Bioconversion, and Pharmacokinetic Evaluation of Ertapenem Prodrugs von Singh, Sheo B, Rindgen, Diane, Bradley, Prudence, Suzuki, Takao, Wang, Nengxue, Wu, Hao, Zhang, Basheng, Wang, Li, Ji, Chongmin, Yu, Hongshi, Soll, Richard M, Olsen, David B, Meinke, Peter T, Nicoll-Griffith, Deborah A

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Synthesis and antibacterial activity of novel water-soluble nocathiacin analogs von Xu, Libo, Farthing, Amy K., Dropinski, James F., Meinke, Peter T., McCallum, Christine, Hickey, Emily, Liu, Kun

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Lithocholic Acid Decreases Expression of Bile Salt Export Pump through Farnesoid X Receptor Antagonist Activity von Yu, Jinghua, Lo, Jane-L, Huang, Li, Zhao, Annie, Metzger, Edward, Adams, Alan, Meinke, Peter T, Wright, Samuel D, Cui, Jisong

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Photochemical preparation of a pyridone containing tetracycle: A Jak protein kinase inhibitor von THOMPSON, James E, CUBBON, Rose M, DEMARTINO, Julie A, CUMMINGS, Richard T, WICKER, Linda S, FRANKSHUN, Robert, CUNNINGHAM, Barry R, CAMERON, Patricia M, MEINKE, Peter T, LIVERTON, Nigel, YOUMIN WENG

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Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3) von Coburn, Craig A., Luo, Yunfu, Cui, Mingxiang, Wang, Jiabing, Soll, Richard, Dong, Jingchao, Hu, Bin, Lyon, Michael A., Santarelli, Vincent P., Kraus, Richard L., Gregan, Yun, Wang, Yi, Fox, Steven V., Binns, Jacquelyn, Doran, Scott M., Reiss, Duane R., Tannenbaum, Pamela L., Gotter, Anthony L., Meinke, Peter T., Renger, John J.

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Indazole to 2‐Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity von Sun, Shan, Ginn, John, Kochanczyk, Tomasz, Arango, Nancy, Jiang, Xiuju, Huggins, David J., Bean, James, Michino, Mayako, Baxt, Leigh, Liverton, Nigel, Meinke, Peter T., Bryk, Ruslana

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Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration von Balbach, Melanie, Fushimi, Makoto, Huggins, David J, Steegborn, Clemens, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

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Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates von Miller, Michael, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Balbach, Melanie, Kaur, Navpreet, Levin, Lonny R., Buck, Jochen, Kehr, Maria, Coquille, Sandrine, van den Heuvel, Joop, Steegborn, Clemens, Fushimi, Makoto, Finkin-Groner, Efrat, Myers, Robert W., Kargman, Stacia, Liverton, Nigel J., Huggins, David J., Meinke, Peter T.

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Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells von Mullarky, Edouard, Xu, Jiayi, Robin, Anita D., Huggins, David J., Jennings, Andy, Noguchi, Naoyoshi, Olland, Andrea, Lakshminarasimhan, Damodharan, Miller, Michael, Tomita, Daisuke, Michino, Mayako, Su, Taojunfeng, Zhang, Guoan, Stamford, Andrew W., Meinke, Peter T., Kargman, Stacia, Cantley, Lewis C.

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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity von Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.

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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia von Liu, Yiman, Li, Qinglan, Alikarami, Fatemeh, Barrett, Declan R, Mahdavi, Leila, Li, Hangpeng, Tang, Sylvia, Khan, Tanweer A, Michino, Mayako, Hill, Connor, Song, Lele, Yang, Lu, Li, Yuanyuan, Pokharel, Sheela Pangeni, Stamford, Andrew W, Liverton, Nigel, Renzetti, Louis M, Taylor, Simon, Watt, Gillian F, Ladduwahetty, Tammy, Kargman, Stacia, Meinke, Peter T, Foley, Michael A, Shi, Junwei, Li, Haitao, Carroll, Martin, Chen, Chun-Wei, Gardini, Alessandro, Maillard, Ivan, Huggins, David J, Bernt, Kathrin M, Wan, Liling

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Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation von Sun, Shan, Fushimi, Makoto, Rossetti, Thomas, Kaur, Navpreet, Ferreira, Jacob, Miller, Michael, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen, Myers, Robert W., Kargman, Stacia, Liverton, Nigel, Meinke, Peter T., Huggins, David J.

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