Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry von WESTBY, Mike, SMITH-BURCHNELL, Caroline, MORI, Julie, LEWIS, Marilyn, MOSLEY, Nichael, STOCKDALE, Mark, DORR, Patrick, CIARAMELLA, Giuseppe, PERROS, Manos

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Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type... von DORR, Patrick, WESTBY, Mike, WEBSTER, Rob, ARMOUR, Duncan, PRICE, David, STAMMEN, Blanda, WOOD, Anthony, PERROS, Manos, DOBBS, Susan, GRIFFIN, Paul, IRVINE, Becky, MACARTNEY, Malcolm, MORI, Julie, RICKETT, Graham, SMITH-BURCHNELL, Caroline, NAPIER, Carolyn

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A sustainable model for antibiotics von Perros, Manos

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HIV capsid is a tractable target for small molecule therapeutic intervention von Blair, Wade S, Pickford, Chris, Irving, Stephen L, Brown, David G, Anderson, Marie, Bazin, Richard, Cao, Joan, Ciaramella, Giuseppe, Isaacson, Jason, Jackson, Lynn, Hunt, Rachael, Kjerrstrom, Anne, Nieman, James A, Patick, Amy K, Perros, Manos, Scott, Andrew D, Whitby, Kevin, Wu, Hua, Butler, Scott L

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Emergence of CXCR4-Using Human Immunodeficiency Virus Type 1 (HIV-1) Variants in a Minority of HIV-1-Infected Patients following Treatment with the CCR5 Antagonist Maraviroc Is fro... von WESTBY, Mike, LEWIS, Marilyn, WHITCOMB, Jeannette, YOULE, Mike, POZNIAK, Anton L, JAMES, Ian T, JENKINS, Tim M, PERROS, Manos, VAN DER RYST, Elna

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Lersivirine, a Nonnucleoside Reverse Transcriptase Inhibitor with Activity against Drug-Resistant Human Immunodeficiency Virus Type 1 von Corbau, Romuald, Mori, Julie, Phillips, Chris, Fishburn, Lesley, Martin, Alex, Mowbray, Charles, Panton, Wendy, Smith-Burchnell, Caroline, Thornberry, Adele, Ringrose, Heather, Knöchel, Thorsten, Irving, Steve, Westby, Mike, Wood, Anthony, Perros, Manos

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A sustainable model for antibiotics: How can we foster the development of novel drugs against resistant bacteria? von Perros, Manos

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New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation von BLAIR, Wade S, CAO, Joan, PICKFORD, Chris, HUA WU, BUTLER, Scott L, FOK-SEANG, Juin, GRIFFIN, Paul, ISAACSON, Jason, LYNN JACKSON, R, MURRAY, Edward, PATRICK, Amy K, QINGHAI PENG, PERROS, Manos

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A Low-Molecular-Weight Entry Inhibitor of both CCR5- and CXCR4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp41 von Murray, Edward J, Leaman, Daniel P, Pawa, Nishant, Perkins, Hannah, Pickford, Chris, Perros, Manos, Zwick, Michael B, Butler, Scott L

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An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imi... von Stupple, Paul A, Batchelor, David V, Corless, Martin, Dorr, Patrick K, Ellis, David, Fenwick, David R, Galan, Sébastien R. G, Jones, Rhys M, Mason, Helen J, Middleton, Donald S, Perros, Manos, Perruccio, Francesca, Platts, Michelle Y, Pryde, David C, Rodrigues, Deborah, Smith, Nicholas N, Stephenson, Peter T, Webster, Robert, Westby, Mike, Wood, Anthony

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Disease-Modifying Therapeutic Concepts for HIV in the Era of Highly Active Antiretroviral Therapy von Butler, Scott L, Valdez, Hernan, Westby, Michael, Perros, Manos, June, Carl H, Jacobson, Jeffrey M, Levy, Yves, Cooper, David A, Douek, Daniel, Lederman, Michael M, Tebas, Pablo

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Challenges and opportunities in the discovery, development, and commercialization of pathogen-targeted antibiotics von Altarac, David, Gutch, Michael, Mueller, John, Ronsheim, Matthew, Tommasi, Ruben, Perros, Manos

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Untargeted Metabolomics To Ascertain Antibiotic Modes of Action von Vincent, Isabel M, Ehmann, David E, Mills, Scott D, Perros, Manos, Barrett, Michael P

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Infectious disease. A sustainable model for antibiotics von Perros, Manos

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5th Antiviral Drug Discovery & Development Summit von Blair, Wade, Perros, Manos

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The Discovery of CCR5 Receptor Antagonists for the Treatment of HIV Infection: Hit-to-Lead Studies von Armour, Duncan, de Groot, Marcel J., Edwards, Martin, Perros, Manos, Price, David A., Stammen, Blanda L., Wood, Anthony

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Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones von Basarab, Gregory S, Ghorpade, Sandeep, Gibhard, Liezl, Mueller, Rudolf, Njoroge, Mathew, Peton, Nashied, Govender, Preshendren, Massoudi, Lisa M, Robertson, Gregory Thomas, Lenaerts, Anne J, Boshoff, Helena Ingrid, Joerss, Douglas, Parish, Tanya, Durand-Reville, Thomas F, Perros, Manos, Singh, Vinayak, Chibale, Kelly

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Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases von Basarab, Gregory S., Kern, Gunther H., McNulty, John, Mueller, John P., Lawrence, Kenneth, Vishwanathan, Karthick, Alm, Richard A., Barvian, Kevin, Doig, Peter, Galullo, Vincent, Gardner, Humphrey, Gowravaram, Madhusudhan, Huband, Michael, Kimzey, Amy, Morningstar, Marshall, Kutschke, Amy, Lahiri, Sushmita D., Perros, Manos, Singh, Renu, Schuck, Virna J. A., Tommasi, Ruben, Walkup, Grant, Newman, Joseph V.

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CCR5 inhibitors in HIV-1 therapy von Dorr, Patrick, Perros, Manos

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Chapter 2 CCR5 Pharmacology Methodologies and Associated Applications von Mansfield, Roy, Able, Sarah, Griffin, Paul, Irvine, Becky, James, Ian, Macartney, Malcolm, Miller, Ken, Mills, James, Napier, Carolyn, Navratilova, Iva, Perros, Manos, Rickett, Graham, Root, Harriet, van der Ryst, Elna, Westby, Mike, Dorr, Patrick

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