Discovery of 2‑[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro‑1H‑isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP‑1... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

Volltext

Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors von Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

Volltext

Identification of candidate substrates for poly(ADP‐ribose) polymerase‐2 (PARP2) in the absence of DNA damage using high‐density protein microarrays von Troiani, Sonia, Lupi, Rosita, Perego, Rita, Re Depaolini, Stefania, Thieffine, Sandrine, Bosotti, Roberta, Rusconi, Luisa

Volltext

Crystal Structure of the Tyrosine Kinase Domain of the Hepatocyte Growth Factor Receptor c-Met and Its Complex with the Microbial Alkaloid K-252a von Schiering, Nikolaus, Knapp, Stefan, Marconi, Marina, Flocco, Maria M., Cui, Jean, Perego, Rita, Rusconi, Luisa, Cristiani, Cinzia

Volltext

The hidden hypothesis: A disseminated tuberculosis case von Foresti, Sergio, Perego, Maria Rita, Carugati, Manuela, Casati, Anna, Malafronte, Cristina, Manzoni, Marco, Badolato, Raffaele, Gori, Andrea, Achilli, Felice

Volltext

Regulation of the Wild-Type and Y1235D Mutant Met Kinase Activation von Cristiani, Cinzia, Rusconi, Luisa, Perego, Rita, Schiering, Nikolaus, Kalisz, Henryk M, Knapp, Stefan, Isacchi, Antonella

Volltext

Identification of 4,5-Dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors von Beria, Italo, Ballinari, Dario, Bertrand, Jay Aaron, Borghi, Daniela, Bossi, Roberto Tiberio, Brasca, Maria Gabriella, Cappella, Paolo, Caruso, Michele, Ceccarelli, Walter, Ciavolella, Antonella, Cristiani, Cinzia, Croci, Valter, De Ponti, Anna, Fachin, Gabriele, Ferguson, Ronald Dale, Lansen, Jacqueline, Moll, Jurgen Karl, Pesenti, Enrico, Posteri, Helena, Perego, Rita, Rocchetti, Maurizio, Storici, Paola, Volpi, Daniele, Valsasina, Barbara

Volltext

Abstract 734: Thienoindoles: New highly promising agents for antibody-drug conjugates generation von Caruso, Michele, Gasparri, Fabio, Valsasina, Barbara, Albanese, Clara, Beria, Italo, Candiani, Ilaria, Ciomei, Marina, Colombo, Nicoletta, Cribioli, Sabrina, Cucchi, Ulisse, Felder, Eduard, Fraietta, Ivan, Galvani, Arturo, Isacchi, Antonella, Marsiglio, Aurelio, Orsini, Paolo, Perego, Rita, Rizzi, Simona, Tomasi, Attilio, Troiani, Sonia, Visco, Carlo, Donati, Daniele

Volltext

'Indeterminate for malignancy' (Tir3/Thy3 in the Italian and British systems for classification) thyroid fine needle aspiration (FNA) cytology reporting: morphological criteria and... von Pagni, F., Prada, M., Goffredo, P., Isimbaldi, G., Crippa, S., Di Bella, C., Leone, B. E.

Volltext

Activation of Zap-70 Tyrosine Kinase Due to a Structural Rearrangement Induced by Tyrosine Phosphorylation and/or ITAM Binding von Visco, Carlo, Magistrelli, Giovanni, Bosotti, Roberta, Perego, Rita, Rusconi, Luisa, Toma, Salvatore, Zamai, Moreno, Acuto, Oreste, Isacchi, Antonella

Volltext

Insights into PARP Inhibitors’ Selectivity Using Fluorescence Polarization and Surface Plasmon Resonance Binding Assays von Papeo, Gianluca, Avanzi, Nilla, Bettoni, Serena, Leone, Antonella, Paolucci, Mauro, Perego, Rita, Quartieri, Francesca, Riccardi-Sirtori, Federico, Thieffine, Sandrine, Montagnoli, Alessia, Lupi, Rosita

Volltext

High-Throughput NMR-Based Screening with Competition Binding Experiments von Dalvit, Claudio, Flocco, Maria, Knapp, Stefan, Mostardini, Marina, Perego, Rita, Stockman, Brian J, Veronesi, Marina, Varasi, Mario

Volltext

Incidental Papillary Thyroid Carcinoma: Diagnostic Findings in a Series of 287 Carcinomas von Pagni, Fabio, Jaconi, Marta, Delitala, Alberto, Garancini, Mattia, Maternini, Matteo, Bono, Francesca, Giani, Alessandro, Smith, Andrew

Volltext

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1 H -isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-... von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Busel, Alina A., Caprera, Francesco, Casale, Elena, Ciomei, Marina, Cirla, Alessandra, Corti, Emiliana, D’Anello, Matteo, Fasolini, Marina, Forte, Barbara, Galvani, Arturo, Isacchi, Antonella, Khvat, Alexander, Krasavin, Mikhail Y., Lupi, Rosita, Orsini, Paolo, Perego, Rita, Pesenti, Enrico, Pezzetta, Daniele, Rainoldi, Sonia, Riccardi-Sirtori, Federico, Scolaro, Alessandra, Sola, Francesco, Zuccotto, Fabio, Felder, Eduard R., Donati, Daniele, Montagnoli, Alessia

Volltext

Abstract A149: NMS-P945, a highly active payload for antibody drug conjugates generation von Gasparri, Fabio, Caruso, Michele, Beria, Italo, Colombo, Nicoletta, Orsini, Paolo, Perego, Rita, Rizzi, Simona, Cucchi, Ulisse, Troiani, Sonia, Riccardi Sirtori, Federico, Albanese, Clara, Marsiglio, Aurelio, Fraietta, Ivan, Sola, Francesco, Ciomei, Marina, Cribioli, Sabrina, Visco, Carlo, Felder, Eduard Rudolf, Isacchi, Antonella, Pesenti, Enrico, Galvani, Arturo, Donati, Daniele, Valsasina, Barbara

Volltext

Abstract 822: Thienoindoles, a novel class of DNA minor groove alkylating agents highly suited for the generation of novel antibody drug conjugates (ADCs) von Valsasina, Barbara, Gasparri, Fabio, Beria, Italo, Colombo, Nicoletta, Orsini, Paolo, Perego, Rita, Rizzi, Simona, Cucchi, Ulisse, Albanese, Clara, Marsiglio, Aurelio, Fraietta, Ivan, Ciomei, Marina, Cribioli, Sabrina, Visco, Carlo, Felder, Eduard R., Isacchi, Antonella, Pesenti, Enrico A., Galvani, Arturo, Donati, Daniele, Caruso, Michele

Volltext

Abstract 691: In vitro and in vivo characterization of selective orally available Parp-1 inhibitors with demonstrated antitumor efficacy in BRCA negative cancer models von Papeo, Gianluca, Rainoldi, Sonia, Gianellini, Laura, Ciavolella, Antonella, Leone, Antonella, Lupi, Rosita, Sola, Francesco, Caprera, Francesco, Paolucci, Mauro, Thieffine, Sandrine, Perego, Rita, Albanese, Clara, Casale, Elena, Forte, Barbara, Guanci, Marco, Orsini, Paolo, Posteri, Helena, Scolaro, Alessandra, Riccardi-Sirtori, Federico, Zuccotto, Fabio, Donati, Daniele, Moll, Jurgen, Montagnoli, Alessia

Volltext

Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds von Lupi Vittoria, Cohen Robert L, Caruso Michele, Perego Rita, Spencer Susan D, Flygare John A, Polakis Paul, Beria Italo, Valsasina Barbara, Polson Andrew, Salsa Matteo

Volltext bestellen

ANTHRACYCLINE DERIVATIVE CONJUGATES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR COMPOUNDS von BERIA, ITALO, VALSASINA, BARBARA, FLYGARE, JOHN A, LUPI, VITTORIA, CARUSO, MICHELE, POLAKIS, PAUL, SALSA, MATTEO, PEREGO, RITA, SPENCER, SUSAN D, POLSON, ANDREW

Volltext bestellen

Role of the Src homology 2 domains and interdomain regions in ZAP‐70 phosphorylation and enzymatic activity von Magistrelli, Giovanni, Bosotti, Roberta, Valsasina, Barbara, Visco, Carlo, Perego, Rita, Toma, Salvatore, Acuto, Oreste, Isacchi, Antonella

Volltext