Statins as Anticancer Agents in the Era of Precision Medicine von Longo, Joseph, van Leeuwen, Jenna E, Elbaz, Mohamad, Branchard, Emily, Penn, Linda Z

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MYC protein interactors in gene transcription and cancer von Lourenco, Corey, Resetca, Diana, Redel, Cornelia, Lin, Peter, MacDonald, Alannah S., Ciaccio, Roberto, Kenney, Tristan M. G., Wei, Yong, Andrews, David W., Sunnerhagen, Maria, Arrowsmith, Cheryl H., Raught, Brian, Penn, Linda Z.

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Dysregulation of the mevalonate pathway promotes transformation von Clendening, James W., Pandyra, Aleks, Boutros, Paul C., Ghamrasni, Samah El, Khosravi, Fereshteh, Trentin, Grace A., Martirosyan, Anna, Hakem, Anne, Hakem, Razqallah, Jurisica, Igor, Penn, Linda Z., Mak, Tak Wah

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The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase von Wei, Yong, Redel, Cornelia, Ahlner, Alexandra, Lemak, Alexander, Johansson-Åkhe, Isak, Houliston, Scott, Kenney, Tristan M G, Tamachi, Aaliya, Morad, Vivian, Duan, Shili, Andrews, David W, Wallner, Björn, Sunnerhagen, Maria, Arrowsmith, Cheryl H, Penn, Linda Z

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Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning von Mergenthaler, Philipp, Hariharan, Santosh, Pemberton, James M, Lourenco, Corey, Penn, Linda Z, Andrews, David W

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MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability von Dingar, Dharmendra, Tu, William B., Resetca, Diana, Lourenco, Corey, Tamachi, Aaliya, De Melo, Jason, Houlahan, Kathleen E., Kalkat, Manpreet, Chan, Pak-Kei, Boutros, Paul C., Raught, Brian, Penn, Linda Z.

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Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance von Martirosyan, Anna, Clendening, James W, Goard, Carolyn A, Penn, Linda Z

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Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins von van Leeuwen, Jenna E., Ba-Alawi, Wail, Branchard, Emily, Cruickshank, Jennifer, Schormann, Wiebke, Longo, Joseph, Silvester, Jennifer, Gross, Peter L., Andrews, David W., Cescon, David W., Haibe-Kains, Benjamin, Penn, Linda Z., Gendoo, Deena M. A.

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The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis von BARSYTE-LOVEJOY, Dalia, LAU, Suzanne K, BOUTROS, Paul C, KHOSRAVI, Fereshteh, JURISICA, Igor, ANDRULIS, Irene L, TSAO, Ming S, PENN, Linda Z

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Reflecting on 25 years with MYC von Meyer, Natalie, Penn, Linda Z.

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An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer von Longo, Joseph, Mullen, Peter J., Yu, Rosemary, van Leeuwen, Jenna E., Masoomian, Mehdi, Woon, Dixon T.S., Wang, Yuzhuo, Chen, Eric X., Hamilton, Robert J., Sweet, Joan M., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.

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Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding von Andresen, Cecilia, Helander, Sara, Lemak, Alexander, Farès, Christophe, Csizmok, Veronika, Carlsson, Jonas, Penn, Linda Z, Forman-Kay, Julie D, Arrowsmith, Cheryl H, Lundström, Patrik, Sunnerhagen, Maria

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Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death von Longo, Joseph, Pandyra, Aleksandra A., Stachura, Paweł, Minden, Mark D., Schimmer, Aaron D., Penn, Linda Z.

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Prognostic gene signatures for non-small-cell lung cancer von Boutros, Paul C, Lau, Suzanne K, Pintilie, Melania, Liu, Ni, Shepherd, Frances A, Der, Sandy D, Tsao, Ming-Sound, Penn, Linda Z, Jurisica, Igor

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The interplay between cell signalling and the mevalonate pathway in cancer von Mullen, Peter J., Yu, Rosemary, Longo, Joseph, Archer, Michael C., Penn, Linda Z.

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Three-Gene Prognostic Classifier for Early-Stage Non–Small-Cell Lung Cancer von LAU, Suzanne K, BOUTROS, Paul C, NI LIU, LAU, Davina, PENN, Linda Z, SHEPHERD, Frances A, JURISICA, Igor, DER, Sandy D, TSAO, Ming-Sound, PINTILIE, Melania, BLACKHALL, Fiona H, ZHU, Chang-Qi, STRUMPF, Dan, JOHNSTON, Michael R, DARLING, Gail, KESHAVJEE, Shaf, WADDELL, Thomas K

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Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma von Clendening, James W., Pandyra, Aleksandra, Li, Zhihua, Boutros, Paul C., Martirosyan, Anna, Lehner, Richard, Jurisica, Igor, Trudel, Suzanne, Penn, Linda Z.

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Modelling the MYC-driven normal-to-tumour switch in breast cancer von Lourenco, Corey, Kalkat, Manpreet, Houlahan, Kathleen E, De Melo, Jason, Longo, Joseph, Done, Susan J, Boutros, Paul C, Penn, Linda Z

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Cancer therapeutics: Targeting the dark side of Myc von Ponzielli, Romina, Katz, Sigal, Barsyte-Lovejoy, Dalia, Penn, Linda Z.

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Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis von JIANGHONG WU, WONG, W. Wei-Lynn, KHOSRAVI, Fereshteh, MINDEN, Mark D, PENN, Linda Z

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