Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance von Pettitt, Stephen J., Krastev, Dragomir B., Brandsma, Inger, Dréan, Amy, Song, Feifei, Aleksandrov, Radoslav, Harrell, Maria I., Menon, Malini, Brough, Rachel, Campbell, James, Frankum, Jessica, Ranes, Michael, Pemberton, Helen N., Rafiq, Rumana, Fenwick, Kerry, Swain, Amanda, Guettler, Sebastian, Lee, Jung-Min, Swisher, Elizabeth M., Stoynov, Stoyno, Yusa, Kosuke, Ashworth, Alan, Lord, Christopher J.

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ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A von Williamson, Chris T., Miller, Rowan, Pemberton, Helen N., Jones, Samuel E., Campbell, James, Konde, Asha, Badham, Nicholas, Rafiq, Rumana, Brough, Rachel, Gulati, Aditi, Ryan, Colm J., Francis, Jeff, Vermulen, Peter B., Reynolds, Andrew R., Reaper, Philip M., Pollard, John R., Ashworth, Alan, Lord, Christopher J.

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MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation von O'Loghlen, Ana, Muñoz-Cabello, Ana M., Gaspar-Maia, Alexandre, Wu, Hsan-Au, Banito, Ana, Kunowska, Natalia, Racek, Tomas, Pemberton, Helen N., Beolchi, Patrizia, Lavial, Fabrice, Masui, Osamu, Vermeulen, Michiel, Carroll, Thomas, Graumann, Johannes, Heard, Edith, Dillon, Niall, Azuara, Veronique, Snijders, Ambrosius P., Peters, Gordon, Bernstein, Emily, Gil, Jesus

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Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines von Campbell, James, Ryan, Colm J., Brough, Rachel, Bajrami, Ilirjana, Pemberton, Helen N., Chong, Irene Y., Costa-Cabral, Sara, Frankum, Jessica, Gulati, Aditi, Holme, Harriet, Miller, Rowan, Postel-Vinay, Sophie, Rafiq, Rumana, Wei, Wenbin, Williamson, Chris T., Quigley, David A., Tym, Joe, Al-Lazikani, Bissan, Fenton, Timothy, Natrajan, Rachael, Strauss, Sandra J., Ashworth, Alan, Lord, Christopher J.

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E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer von Bajrami, Ilirjana, Marlow, Rebecca, van de Ven, Marieke, Brough, Rachel, Pemberton, Helen N, Frankum, Jessica, Song, Feifei, Rafiq, Rumana, Konde, Asha, Krastev, Dragomir B, Menon, Malini, Campbell, James, Gulati, Aditi, Kumar, Rahul, Pettitt, Stephen J, Gurden, Mark D, Cardenosa, Marta Llorca, Chong, Irene, Gazinska, Patrycja, Wallberg, Fredrik, Sawyer, Elinor J, Martin, Lesley-Ann, Dowsett, Mitch, Linardopoulos, Spiros, Natrajan, Rachael, Ryan, Colm J, Derksen, Patrick W B, Jonkers, Jos, Tutt, Andrew N J, Ashworth, Alan, Lord, Christopher J

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Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells von Vinci, Mara, Burford, Anna, Molinari, Valeria, Kessler, Ketty, Popov, Sergey, Clarke, Matthew, Taylor, Kathryn R., Pemberton, Helen N., Lord, Christopher J., Gutteridge, Alice, Forshew, Tim, Carvalho, Diana, Marshall, Lynley V., Qin, Elizabeth Y., Ingram, Wendy J., Moore, Andrew S., Ng, Ho-Keung, Trabelsi, Saoussen, H’mida-Ben Brahim, Dorra, Entz-Werle, Natacha, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C., Bridges, Leslie R., Martin, Andrew J., Al-Sarraj, Safa, Chandler, Christopher, Sunol, Mariona, Mora, Jaume, de Torres, Carmen, Cruz, Ofelia, Carcaboso, Angel M., Monje, Michelle, Mackay, Alan, Jones, Chris

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Modeling Therapy Resistance in BRCA1/2 -Mutant Cancers von Dréan, Amy, Williamson, Chris T, Brough, Rachel, Brandsma, Inger, Menon, Malini, Konde, Asha, Garcia-Murillas, Isaac, Pemberton, Helen N, Frankum, Jessica, Rafiq, Rumana, Badham, Nicholas, Campbell, James, Gulati, Aditi, Turner, Nicholas C, Pettitt, Stephen J, Ashworth, Alan, Lord, Christopher J

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Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells von Nikkilä, Jenni, Kumar, Rahul, Campbell, James, Brandsma, Inger, Pemberton, Helen N, Wallberg, Fredrik, Nagy, Kinga, Scheer, Ildikó, Vertessy, Beata G, Serebrenik, Artur A, Monni, Valentina, Harris, Reuben S, Pettitt, Stephen J, Ashworth, Alan, Lord, Christopher J

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SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response von Bland, Philip, Saville, Harry, Wai, Patty T., Curnow, Lucinda, Muirhead, Gareth, Nieminuszczy, Jadwiga, Ravindran, Nivedita, John, Marie Beatrix, Hedayat, Somaieh, Barker, Holly E., Wright, James, Yu, Lu, Mavrommati, Ioanna, Read, Abigail, Peck, Barrie, Allen, Mark, Gazinska, Patrycja, Pemberton, Helen N., Gulati, Aditi, Nash, Sarah, Noor, Farzana, Guppy, Naomi, Roxanis, Ioannis, Pratt, Guy, Oldreive, Ceri, Stankovic, Tatjana, Barlow, Samantha, Kalirai, Helen, Coupland, Sarah E., Broderick, Ronan, Alsafadi, Samar, Houy, Alexandre, Stern, Marc-Henri, Pettit, Stephen, Choudhary, Jyoti S., Haider, Syed, Niedzwiedz, Wojciech, Lord, Christopher J., Natrajan, Rachael

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ATR Is a Therapeutic Target in Synovial Sarcoma von Jones, Samuel E, Fleuren, Emmy D G, Frankum, Jessica, Konde, Asha, Williamson, Chris T, Krastev, Dragomir B, Pemberton, Helen N, Campbell, James, Gulati, Aditi, Elliott, Richard, Menon, Malini, Selfe, Joanna L, Brough, Rachel, Pettitt, Stephen J, Niedzwiedz, Wojciech, van der Graaf, Winette T A, Shipley, Janet, Ashworth, Alan, Lord, Christopher J

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Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma von George, Sally L, Lorenzi, Federica, King, David, Hartlieb, Sabine, Campbell, James, Pemberton, Helen, Toprak, Umut H, Barker, Karen, Tall, Jennifer, da Costa, Barbara Martins, van den Boogaard, Marlinde L, Dolman, M Emmy M, Molenaar, Jan J, Bryant, Helen E, Westermann, Frank, Lord, Christopher J, Chesler, Louis

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Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells von Nikkilä, Jenni, Kumar, Rahul, Campbell, James, Brandsma, Inger, Pemberton, Helen N, Wallberg, Fredrik, Nagy, Kinga, Scheer, Ildikó, Vertessy, Beata G, Serebrenik, Artur A, Monni, Valentina, Harris, Reuben S, Pettitt, Stephen J, Ashworth, Alan, Lord, Christopher J

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Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness von Holme, Harriett, Gulati, Aditi, Brough, Rachel, Fleuren, Emmy D. G., Bajrami, Ilirjana, Campbell, James, Chong, Irene Y., Costa-Cabral, Sara, Elliott, Richard, Fenton, Tim, Frankum, Jessica, Jones, Samuel E., Menon, Malini, Miller, Rowan, Pemberton, Helen N., Postel-Vinay, Sophie, Rafiq, Rumana, Selfe, Joanna L., von Kriegsheim, Alex, Munoz, Amaya Garcia, Rodriguez, Javier, Shipley, Janet, van der Graaf, Winette T. A., Williamson, Chris T., Ryan, Colm J., Pettitt, Stephen, Ashworth, Alan, Strauss, Sandra J., Lord, Christopher J.

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Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration von Bussolati, Benedetta, Ahmed, Asif, Pemberton, Helen, Landis, R. Clive, Di Carlo, Francesco, Haskard, Dorian O., Mason, Justin C.

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Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds) von Wishart, Thomas M, Pemberton, Helen N, James, Sally R, McCabe, Chris J, Gillingwater, Thomas H

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Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness von Holme, Harriett, Gulati, Aditi, Brough, Rachel, Fleuren, Emmy D. G., Bajrami, Ilirjana, Campbell, James, Chong, Irene Y., Costa-Cabral, Sara, Elliott, Richard, Fenton, Tim, Frankum, Jessica, Jones, Samuel E., Menon, Malini, Miller, Rowan, Pemberton, Helen N., Postel-Vinay, Sophie, Rafiq, Rumana, Selfe, Joanna L., von Kriegsheim, Alex, Munoz, Amaya Garcia, Rodriguez, Javier, Shipley, Janet, van der Graaf, Winette T. A., Williamson, Chris T., Ryan, Colm J., Pettitt, Stephen, Ashworth, Alan, Strauss, Sandra J., Lord, Christopher J.

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Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells von Pettitt, Stephen J., Krastev, Dragomir B., Pemberton, Helen N., Fontebasso, Yari, Frankum, Jessica, Rehman, Farah L., Brough, Rachel, Song, Feifei, Bajrami, Ilirjana, Rafiq, Rumana, Wallberg, Fredrik, Kozarewa, Iwanka, Fenwick, Kerry, Armisen-Garrido, Javier, Swain, Amanda, Gulati, Aditi, Campbell, James, Ashworth, Alan, Lord, Christopher J.

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RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress von Kanu, N, Zhang, T, Burrell, R A, Chakraborty, A, Cronshaw, J, DaCosta, C, Grönroos, E, Pemberton, H N, Anderton, E, Gonzalez, L, Sabbioneda, S, Ulrich, H D, Swanton, C, Behrens, A

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Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance von Tarantino, Dalia, Walker, Callum, Weekes, Daniel, Pemberton, Helen, Davidson, Kathryn, Torga, Gonzalo, Frankum, Jessica, Mendes-Pereira, Ana M., Prince, Cynthia, Ferro, Riccardo, Brough, Rachel, Pettitt, Stephen J., Lord, Christopher J., Grigoriadis, Anita, NJ Tutt, Andrew

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Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib von Miller, Rowan E, Brough, Rachel, Bajrami, Ilirjana, Williamson, Chris T, McDade, Simon, Campbell, James, Kigozi, Asha, Rafiq, Rumana, Pemberton, Helen, Natrajan, Rachel, Joel, Josephine, Astley, Holly, Mahoney, Claire, Moore, Jonathan D, Torrance, Chris, Gordan, John D, Webber, James T, Levin, Rebecca S, Shokat, Kevan M, Bandyopadhyay, Sourav, Lord, Christopher J, Ashworth, Alan

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