Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors von Swarbrick, Martin E., Beswick, Paul J., Gleave, Robert J., Green, Richard H., Bingham, Sharon, Bountra, Chas, Carter, Malcolm C., Chambers, Laura J., Chessell, Iain P., Clayton, Nick M., Collins, Sue D., Corfield, John A., Hartley, C. David, Kleanthous, Savvas, Lambeth, Paul F., Lucas, Fiona S., Mathews, Neil, Naylor, Alan, Page, Lee W., Payne, Jeremy J., Pegg, Neil A., Price, Helen S., Skidmore, John, Stevens, Alexander J., Stocker, Richard, Stratton, Sharon C., Stuart, Alastair J., Wiseman, Joanne O.

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Potent Pre-Clinical and Early Phase Clinical Activity of EP300/CBP Bromodomain Inhibitor CCS1477 in Multiple Myeloma von Nicosia, Luciano, Brooks, Nigel, Amaral, Fabio, Sinclair, Oliver, Pegg, Neil A, West, William, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Cavet, James, Searle, Emma, Somervaille, Tim C.P

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CCS1477, a Novel p300/CBP Bromodomain Inhibitor, Enhances Efficacy of Azacitidine and Venetoclax in Pre-Clinical Models of Acute Myeloid Leukaemia and Lymphoma von Brooks, Nigel, Knurowski, Tomasz, Hughes, Andrew, Clegg, Karen, West, William, Pegg, Neil A, Spencer, Gary J, Chadwick, John, Somervaille, Tim C.P

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CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma von Brooks, Nigel, Raja, Meera, Young, Barbara W, Spencer, Gary J, Somervaille, Tim CP, Pegg, Neil A

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Therapeutic Targeting of EP300/CBP By Bromodomain Inhibition in Acute Myeloid Leukemia von Nicosia, Luciano, Spencer, Gary J, Brooks, Nigel, Amaral, Fabio, Basma, Naseer, Chadwick, John, Revell, Bradley, Wingelhofer, Bettina, Maiques-Diaz, Alba, Ciceri, Filippo, Wiseman, Daniel H, Pegg, Neil A, West, William, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Campbell, Victoria Louise, Copland, Mhairi, Searle, Emma, Somervaille, Tim C.P

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An Open-Label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477, a First in Clinic Inhibitor of the p300/CPB Bromodomains, As Monotherapy in Patients with Advanced H... von Knurowski, Tomasz, Clegg, Karen, Brooks, Nigel, Ashby, Fay, Pegg, Neil A, West, William, Walter, Harriet S, Somervaille, Tim CP, Knapper, Steven, Davies, Andrew

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Thrombin inhibitors based on [5,5] trans-fused indane lactams von Pass, Martin, Abu-Rabie, Said, Baxter, Andrew, Conroy, Richard, Coote, Steven J, Craven, Andrew P, Finch, Harry, Hindley, Seán, Kelly, Henry A, Lowdon, Andrew W, McDonald, Edward, Mitchell, William L, Pegg, Neil A, Procopiou, Pan A, Ramsden, Nigel G, Thomas, Rhian, Walker, Dawn A, Watson, Nigel S, Jhoti, Harren, Mooney, Christopher J, Tang, Chi-Man, Thomas, Pamela J, Parry, Simon, Patel, Champa

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Lewis acid induced rearrangement of 2,3-epoxy sulfides; regiospecific trapping of thiiranium ion intermediates with nitrogen heterocycles and amides. Use of imines as nucleophilic... von Gill, Duncan M, Pegg, Neil A, Rayner, Christopher M

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[3.3] Sigmatropy within 1-vinyl-2-alkenyl-7,7-dimethyl-exo-norbornan-2-ols. The first atropselective oxyanionic Cope rearrangement von Paquette, Leo A, Pegg, Neil A, Toops, Dana, Maynard, George D, Rogers, Robin D

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Synthesis of trans-fused [5,5] bicyclic lactones/lactams as templates for serine protease inhibition von Kelly, Henry A., Bolton, Richard, Brown, Stuart A., Coote, Steven J., Dowle, Mike, Dyer, Ulrich, Finch, Harry, Golding, Doreen, Lowdon, Andrew, McLaren, Jessica, Montana, John G., Owen, Martin R., Pegg, Neil A., Ross, Barry C., Thomas, Rhian, Walker, Dawn A.

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Functionalization reactions of a medium-ring bridgehead enone that skirt transannular bond formation von Pegg, Neil A, Paquette, Leo A

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Direct oxygenation of enolates generated by anionic oxy-Cope rearrangement. Expedient preparation of polycyclic .alpha.-hydroxy ketones von Paquette, Leo A, DeRussy, Donald T, Pegg, Neil A, Taylor, Richard T, Zydowsky, Thomas M

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Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimi-dinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors von SWARBRICK, Martin E, BESWICK, Paul J, COLLINS, Sue D, CORFIELD, John A, HARTLEY, C. David, KLEANTHOUS, Sawas, LAMBETH, Paul F, LUCAS, Fiona S, MATHEWS, Neil, NAYLOR, Alan, PAGE, Lee W, PAYNE, Jeremy J, GLEAVE, Robert J, PEGG, Neil A, PRICE, Helen S, SKIDMORE, John, STEVENS, Alexander J, STOCKER, Richard, STRATTON, Sharon C, STUART, Alastair J, WISEMAN, Joanne O, GREEN, Richard H, BINGHAM, Sharon, BOUNTRA, Chas, CARTER, Malcolm C, CHAMBERS, Laura J, CHESSELL, Lain P, CLAYTON, Nick M

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Lewis acid-induced rearrangement of 2,3-epoxy sulfides : regiospecific nucleophilic trapping of thiiranium ion intermediates with nitrogen nucleophiles von GILL, D. M, PEGG, N. A, RAYNER, C. M

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Synthesis of grevillins, novel pyrandione pigments of fungi. Biogenetic interrelationships between grevillins. Pulvinic acids, terphenylquinones and xylerythrins von PATTENDEN, G, PEGG, N. A, KENYON, R. W

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Discovery of an Orally Bioavailable NK1 Receptor Antagonist, (2S,3S)-(2-Methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with Potent Antiemetic Activity von Ward, Peter, Armour, Duncan R, Bays, David E, Evans, Brian, Giblin, Gerard M. P, Heron, Nicola, Hubbard, Tania, Liang, Kai, Middlemiss, David

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The synthesis of a conformationally restrained, combined thromboxane antagonist / synthase inhibitor using an intramolecular ‘Stille’- or ‘Grigg’-palladium-catalysed cyclisation st... von Finch, Harry, Pegg, Neil A., Evans, Brian

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5,5- Trans lactone-containing inhibitors of serine proteases: Identification of a novel, acylating thrombin inhibitor von Finch, Harry, Pegg, Neil A., McLaren, Jessica, Lowdon, Andrew, Bolton, Richard, Coote, Steve J., Dyer, Ulrich, Montana, John G., Owen, Martin R., Dowle, Mike, Buckley, Doreen, Ross, Barry C., Campbell, Callum, Dix, Clive, Mooney, Christopher, Man-Tang, Chi, Patel, Champa

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Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin von Pass, Martin, Bolton, Richard E., Coote, Steven J., Finch, Harry, Hindley, Sean, Lowdon, Andrew, McDonald, Edward, McLaren, Jessica, Owen, Martin, Pegg, Neil A., Mooney, Christopher J., Tang, Chi-Man, Parry, Simon, Patel, Champa

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Reaction of α-amino esters and α-amino ester imines with thiiranium ion intermediates. Application to the synthesis of new potential aminopeptidase inhibitors and mechanistic impli... von Gill, Duncan M, Pegg, Neil A, Rayner, Christopher M

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