Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor von Maira, Sauveur-Michel, Pecchi, Sabina, Huang, Alan, Burger, Matthew, Knapp, Mark, Sterker, Dario, Schnell, Christian, Guthy, Daniel, Nagel, Tobi, Wiesmann, Marion, Brachmann, Saskia, Fritsch, Christine, Dorsch, Marion, Chène, Patrick, Shoemaker, Kevin, De Pover, Alain, Menezes, Daniel, Martiny-Baron, Georg, Fabbro, Doriano, Wilson, Christopher J, Schlegel, Robert, Hofmann, Francesco, García-Echeverría, Carlos, Sellers, William R, Voliva, Charles F

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Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer von Burger, Matthew T, Pecchi, Sabina, Wagman, Allan, Ni, Zhi-Jie, Knapp, Mark, Hendrickson, Thomas, Atallah, Gordana, Pfister, Keith, Zhang, Yanchen, Bartulis, Sarah, Frazier, Kelly, Ng, Simon, Smith, Aaron, Verhagen, Joelle, Haznedar, Joshua, Huh, Kay, Iwanowicz, Ed, Xin, Xiaohua, Menezes, Daniel, Merritt, Hanne, Lee, Isabelle, Wiesmann, Marion, Kaufman, Susan, Crawford, Kenneth, Chin, Michael, Bussiere, Dirksen, Shoemaker, Kevin, Zaror, Isabel, Maira, Sauveur-Michel, Voliva, Charles F

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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor von Karpov, Alexei S, Amiri, Payman, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Daniel, Dylan, Denay, Regis, Fabbro, Doriano, Fernandez, Cesar, Galuba, Inga, Guerro-Lagasse, Stephanie, Gutmann, Sascha, Hinh, Linda, Jahnke, Wolfgang, Klopp, Julia, Lai, Albert, Lindvall, Mika K, Ma, Sylvia, Möbitz, Henrik, Pecchi, Sabina, Rummel, Gabriele, Shoemaker, Kevin, Trappe, Joerg, Voliva, Charles, Cowan-Jacob, Sandra W, Marzinzik, Andreas L

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Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors von Burger, Matthew T, Knapp, Mark, Wagman, Allan, Ni, Zhi-Jie, Hendrickson, Thomas, Atallah, Gordana, Zhang, Yanchen, Frazier, Kelly, Verhagen, Joelle, Pfister, Keith, Ng, Simon, Smith, Aaron, Bartulis, Sarah, Merrit, Hanne, Weismann, Marion, Xin, Xiaohua, Haznedar, Joshua, Voliva, Charles F, Iwanowicz, Ed, Pecchi, Sabina

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A New Bromo Trienyne:  Synthesis of all-E, Conjugated Tetra-, Penta-, and Hexaenes Common to Oxo Polyene Macrolide Antibiotics von Lipshutz, Bruce H, Ullman, Brett, Lindsley, Craig, Pecchi, Sabina, Buzard, D. J, Dickson, David

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Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors von Renhowe, Paul A, Pecchi, Sabina, Shafer, Cynthia M, Machajewski, Timothy D, Jazan, Elisa M, Taylor, Clarke, Antonios-McCrea, William, McBride, Christopher M, Frazier, Kelly, Wiesmann, Marion, Lapointe, Gena R, Feucht, Paul H, Warne, Robert L, Heise, Carla C, Menezes, Daniel, Aardalen, Kimberly, Ye, Helen, He, Molly, Le, Vincent, Vora, Jayesh, Jansen, Johanna M, Wernette-Hammond, Mary Ellen, Harris, Alex L

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Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model von Han, Wooseok, Menezes, Daniel L., Xu, Yongjin, Knapp, Mark S., Elling, Robert, Burger, Matthew T., Ni, Zhi-Jie, Smith, Aaron, Lan, Jiong, Williams, Teresa E., Verhagen, Joelle, Huh, Kay, Merritt, Hanne, Chan, John, Kaufman, Susan, Voliva, Charles F., Pecchi, Sabina

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Identification and structure–activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors von Pecchi, Sabina, Renhowe, Paul A., Taylor, Clarke, Kaufman, Susan, Merritt, Hanne, Wiesmann, Marion, Shoemaker, Kevin R., Knapp, Mark S., Ornelas, Elizabeth, Hendrickson, Thomas F., Fantl, Wendy, Voliva, Charles F.

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Different Pathways in the Base-Promoted Isomerization of Benzyl Oxiranyl Ethers von Mordini, Alessandro, Bindi, Simona, Pecchi, Sabina, Degl'Innocenti, Alessandro, Reginato, Gianna, Serci, Alessandro

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Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K von Pecchi, Sabina, Ni, Zhi-Jie, Han, Wooseok, Smith, Aaron, Lan, Jiong, Burger, Matthew, Merritt, Hanne, Wiesmann, Marion, Chan, John, Kaufman, Susan, Knapp, Mark S., Janssen, Johanna, Huh, Kay, Voliva, Charles F.

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4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors von Ni, Zhi-Jie, Barsanti, Paul, Brammeier, Nathan, Diebes, Anthony, Poon, Daniel J., Ng, Simon, Pecchi, Sabina, Pfister, Keith, Renhowe, Paul A., Ramurthy, Savithri, Wagman, Allan S., Bussiere, Dirksen E., Le, Vincent, Zhou, Yasheen, Jansen, Johanna M., Ma, Sylvia, Gesner, Thomas G.

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Heteroatom-Assisted Isomerization of Oxiranes to Allylic Alcohols Promoted by Bases von Mordini, Alessandro, Pecchi, Sabina, Capozzi, Giuseppe, Capperucci, Antonella, Degl'Innocenti, Alessandro, Reginato, Gianna, Ricci, Alfredo

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Abstract 4497: NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials, shows significant antitumor activity in xenograft and primary tumor models von Maira, Michel, Menezes, Daniel, Pecchi, Sabina, Shoemaker, Kevin, Burger, Matthew, Schnell, christian, Fritsch, christine, Brachmann, Saskia, Nagel, Tobi, Sellers, William R., Garcia-Echeverria, Carlos, Wiesmann, Marion, Voliva, charles F.

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Abstract 4498: Biological characterization of NVP-BKM120, a novel inhibitor of phosphoinosotide 3-kinase in Phase I/II clinical trials von Voliva, charles F., Pecchi, Sabina, Burger, Matthew, Nagel, Tobi, Schnell, Christian, Fritsch, christine, Brachmann, saskia, Menezes, Daniel, Knapp, Mark, Shoemaker, Kevin, Wiesmann, Marion, Huh, kay, Zaror, Isabel, Dorsch, Marion, Sellers, William R., Garcia-Echeverria, Carlos, Maira, Michel

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Design and structure–activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases von Frazier, Kelly, Jazan, Elisa, McBride, Christopher M., Pecchi, Sabina, Renhowe, Paul A., Shafer, Cynthia M., Taylor, Clarke, Bussiere, Dirksen, He, Molly Min, Jansen, Johanna M., Lapointe, Gena, Ma, Sylvia, Vora, Jayesh, Wiesmann, Marion

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LHMDS mediated tandem acylation–cyclization of 2-aminobenzenecarbonitriles with 2-benzymidazol-2-yl acetates: a short and efficient route to the synthesis of 4-amino-3-benzimidazol... von Antonios-McCrea, William R., Frazier, Kelly A., Jazan, Elisa M., Machajewski, Timothy D., McBride, Christopher M., Pecchi, Sabina, Renhowe, Paul A., Shafer, Cynthia M., Taylor, Clarke

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Stannylcupration of γ-heterosubstituted acetylenic esters: A new route to 4-stannylated five membered N- and O- heterocycles von Reginato, Gianna, Capperucci, Antonella, Degl'Innocenti, Alessandro, Mordini, Alessandro, Pecchi, Sabina

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A Selective and General Access to Trisubstituted Oxetanes von Mordini, Alessandro, Bindi, Simona, Pecchi, Sabina, Capperucci, Antonella, Degl'Innocent, Alessandro, Reginato, Gianna

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AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS von ZHU, SHEJIN, JIN, JEFF XIANMING, ZHANG, QIONG, PECCHI, SABINA, MIN, ZHONGCHENG, DING, YU, WANG, XIAOJING MICHAEL, HAN, WOOSEOK, POON, DANIEL, PFISTER, KEITH BRUCE, HUANG, ZILIN, LINDVALL, MIKA, KOU, XIANG, PAN, YUE, JIANG, QUN, BAGDANOFF, JEFFREY T, RAUNIYAR, VIVEK, ZHOU, JIANGUANG, LEE, PATRICK

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A Direct Metalation Approach to 2-Alkylthio-2,2-Diaryl Substituted Acetic Acids von Gualtieri, Fulvio, Mordini, Alessandro, Pecchi, Sabina, Scapecchi, Serena

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